Gene: JAK3

3718
JAK-3|JAK3_HUMAN|JAKL|L-JAK|LJAK
Janus kinase 3
protein-coding
19p13.11
Ensembl:ENSG00000105639 MIM:600173 Vega:OTTHUMG00000165648 UniprotKB:P52333
NG_007273.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.079e-1 (AD)  2.406e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18145683chr19:17959281JAK3Promoter4.087e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGAP90.788
C1RL0.769
C20.766
PTPN20.764
DENND30.76
LPAR20.759
SLAMF80.753
POU2F20.752
PTP4A30.745
MKNK10.739

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.347
HES5-0.342
OR4F29-0.325
RERGL-0.275
GLIPR1L2-0.267
ARSF-0.265
NKX2-8-0.261
SLC27A6-0.26
EDN3-0.256
SLC22A6-0.252

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB047162-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONESmall MoleculeExperimentalTarget
DB08895TofacitinibSmall Molecule477600-75-2Approved|InvestigationalTarget
DB11817BaricitinibSmall Molecule1187594-09-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4172072,2',4,6,6'-pentachlorobiphenyl"2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of JAK3 protein"16778083
C4172072,2',4,6,6'-pentachlorobiphenyl"PD168393 inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of JAK3 protein]"16778083
C5240632-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [OSM protein results in increased phosphorylation of JAK3 protein]"21548952
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of JAK3 mRNA16788091
C5622443-(5-(4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl)-2-trifluoromethylphenyl)-4-(1H-indol-3-yl)pyrrole-2,5-dione"3-(5-(4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl)-2-trifluoromethylphenyl)-4-(1H-indol-3-yl)pyrrole-2,5-dione results in decreased activity of JAK3 protein"21155605
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of JAK3 mRNA22230336|2669055
D000082AcetaminophenAcetaminophen affects the expression of JAK3 mRNA17562736
C016601afimoxifeneJAK3 results in decreased susceptibility to afimoxifene21233418
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK3 protein"25061499
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of JAK3 mRNA24449571
D001151ArsenicArsenic affects the methylation of JAK3 gene25304211
C006632arsenic trioxide[arsenic trioxide co-treated with decitabine] results in decreased expression of JAK3 mRNA24762999
C006632arsenic trioxidearsenic trioxide results in decreased expression of JAK3 mRNA24762999
C000596027baricitinibbaricitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK3 protein]23968543
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of JAK3 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of JAK3 mRNA26377693
D004958EstradiolEstradiol results in increased expression of JAK3 mRNA15289156
C006780bisphenol Abisphenol A affects the expression of JAK3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of JAK3 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of JAK3 promoter22457795
D060729Coal AshCoal Ash results in decreased expression of JAK3 mRNA19000753
D003474CurcuminCurcumin results in decreased activity of JAK3 protein16932349
D003474CurcuminCurcumin results in decreased activity of JAK3 protein26244872
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of JAK3 mRNA24317228
C014347decitabine[arsenic trioxide co-treated with decitabine] results in decreased expression of JAK3 mRNA24762999
C014347decitabinedecitabine results in decreased expression of JAK3 mRNA24762999
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of JAK3 mRNA15766595
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of JAK3 mRNA15289156
C026066enterotoxin A, Staphylococcal"JAK3 affects the reaction [enterotoxin A, Staphylococcal results in increased secretion of IL17A protein]"26738536
C118739entinostatentinostat results in increased expression of JAK3 mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of JAK3 protein22348037
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of JAK3 protein modified form22348037
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of JAK3 gene16724327
D005419FlavonoidsFlavonoids results in increased expression of JAK3 mRNA18035473
D019833GenisteinGenistein results in increased expression of JAK3 mRNA15289156
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of JAK3 mRNA19376150
C545385MequindoxMequindox results in increased expression of JAK3 mRNA21146578
D008694MethamphetamineMethamphetamine results in increased expression of JAK3 mRNA26307267
D008727MethotrexateMethotrexate results in decreased expression of JAK3 mRNA17400583
D008774MethylphenidateMethylphenidate results in decreased expression of JAK3 mRNA22470460
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [IL7 protein results in increased phosphorylation of JAK3 protein]26921788
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased phosphorylation of JAK3 protein26518055
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of JAK3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of JAK3 mRNA"25554681|2562005
D009532NickelNickel results in increased expression of JAK3 mRNA25583101
C509204PD168393"PD168393 inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of JAK3 protein]"16778083
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of JAK3 mRNA28973697
C554945PF 956980PF 956980 inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK3 protein]23968543
C554945PF 956980PF 956980 results in decreased activity of JAK3 protein23968543
D015232DinoprostoneDinoprostone results in decreased phosphorylation of and results in decreased activity of JAK3 protein19812686
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of JAK3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of JAK3 mRNA19710929
C545373ponatinibponatinib results in decreased activity of JAK3 protein19878872
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of JAK3 mRNA25895662
C017947sodium arsenitesodium arsenite inhibits the reaction [IL7 protein results in increased phosphorylation of JAK3 protein]26921788
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of JAK3 protein26518055
C061133tamibarotenetamibarotene results in decreased expression of JAK3 mRNA20861477
D013629TamoxifenTamoxifen results in increased expression of JAK3 mRNA19031437
C004648testosterone enanthatetestosterone enanthate results in increased expression of JAK3 mRNA25603467
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of JAK3 mRNA21570461
C402769tipifarnibtipifarnib results in increased expression of JAK3 mRNA16403772
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of JAK3 mRNA28065790
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK3 protein]23968543
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK3 protein]21548952
C479163tofacitinibtofacitinib results in decreased activity of JAK3 protein23689514|2488333
C479163tofacitinibtofacitinib results in decreased activity of JAK3 protein21155605|2184413
D014118Toxins, Biological"Toxins, Biological affects the expression of JAK3 mRNA"19682533
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of JAK3 mRNA"26179874
C101044tyrphostin AG 1478tyrphostin AG 1478 results in decreased phosphorylation of and results in decreased activity of JAK3 protein16932349
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of JAK3 mRNA26272509
D014639VanadiumVanadium results in decreased expression of JAK3 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of JAK3 gene25560391
C116180WHI P131WHI P131 results in decreased phosphorylation of and results in decreased activity of JAK3 protein16932349
C116180WHI P131WHI P131 results in decreased activity of JAK3 protein14615384
C113888WHI P154WHI P154 results in decreased phosphorylation of and results in decreased activity of JAK3 protein16932349
C113888WHI P154WHI P154 results in decreased activity of JAK3 protein11173405
C118361WHI P180WHI P180 results in decreased activity of JAK3 protein11173405
D015032ZincZinc results in increased expression of JAK3 mRNA19071009
C088658zoledronic acidzoledronic acid results in increased expression of JAK3 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-ISS-  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI9045636  25852190  
GO:0005524ATP binding-IEA-  
GO:0019903protein phosphatase binding-IPI11909529  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0002250adaptive immune response-IEA-  
GO:0002731negative regulation of dendritic cell cytokine production-ISS-  
GO:0006468protein phosphorylation-TAS8022790  
GO:0007167enzyme linked receptor protein signaling pathway-ISS-  
GO:0007260tyrosine phosphorylation of STAT protein-IBA21873635  
GO:0007260tyrosine phosphorylation of STAT protein-TAS19290934  
GO:0018108peptidyl-tyrosine phosphorylation-ISS-  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030183B cell differentiation-IBA21873635  
GO:0030183B cell differentiation-ISS-  
GO:0030218erythrocyte differentiation-IBA21873635  
GO:0032693negative regulation of interleukin-10 production-ISS-  
GO:0032695negative regulation of interleukin-12 production-ISS-  
GO:0035556intracellular signal transduction-ISS-  
GO:0035723interleukin-15-mediated signaling pathway-TAS-  
GO:0035771interleukin-4-mediated signaling pathway-IDA7538655  
GO:0038110interleukin-2-mediated signaling pathway-TAS-  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0038113interleukin-9-mediated signaling pathway-TAS-  
GO:0038114interleukin-21-mediated signaling pathway-TAS-  
GO:0042102positive regulation of T cell proliferation-IBA21873635  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043029T cell homeostasis-IBA21873635  
GO:0043029T cell homeostasis-ISS-  
GO:0043029T cell homeostasis-TAS19290934  
GO:0045221negative regulation of FasL biosynthetic process-ISS-  
GO:0045626negative regulation of T-helper 1 cell differentiation-ISS-  
GO:0046425regulation of JAK-STAT cascade-TAS19290934  
GO:0050868negative regulation of T cell activation-ISS-  
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TAS19290934  
GO:0070232regulation of T cell apoptotic process-ISS-  
GO:0070244negative regulation of thymocyte apoptotic process-ISS-  
GO:0070669response to interleukin-2-TAS9973401  
GO:0070670response to interleukin-4-IDA7538655  7594533  
GO:0070672response to interleukin-15-TAS7594533  
GO:0071104response to interleukin-9-TAS7594533  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-TAS-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-451927Interleukin-2 family signalingIEA
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-8854691Interleukin-20 family signalingTAS
R-HSA-8983432Interleukin-15 signalingTAS
R-HSA-8983432Interleukin-15 signalingIEA
R-HSA-8985947Interleukin-9 signalingTAS
R-HSA-9020558Interleukin-2 signalingTAS
R-HSA-9020958Interleukin-21 signalingTAS
R-HSA-912526Interleukin receptor SHC signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27003425Inflammatory and Immune Response Genes Polymorphisms are Associated with Susceptibility to Chronic Obstructive Pulmonary Disease in Tatars Population from Russia. (2016 Aug)Korytina GFBiochem Genet