Gene info: ID 3718

Gene: JAK3

GENE ID: 3718

Synonyms: JAK-3|JAK3_HUMAN|JAKL|L-JAK|LJAK

Description: Janus kinase 3

Gene type: protein-coding

Location: 19p13.11

dbXrefs: Ensembl:ENSG00000105639 MIM:600173 Vega:OTTHUMG00000165648 UniprotKB:P52333

RefSeq: NG_007273.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.079e-1 (AD) 2.406e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg18145683	chr19:17959281	JAK3	Promoter	4.087e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ARHGAP9	0.788
C1RL	0.769
C2	0.766
PTPN2	0.764
DENND3	0.76
LPAR2	0.759
SLAMF8	0.753
POU2F2	0.752
PTP4A3	0.745
MKNK1	0.739

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.347
HES5	-0.342
OR4F29	-0.325
RERGL	-0.275
GLIPR1L2	-0.267
ARSF	-0.265
NKX2-8	-0.261
SLC27A6	-0.26
EDN3	-0.256
SLC22A6	-0.252

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04716	2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE	Small Molecule		Experimental	Target
DB08895	Tofacitinib	Small Molecule	477600-75-2	Approved\|Investigational	Target
DB11817	Baricitinib	Small Molecule	1187594-09-7	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C417207	2,2',4,6,6'-pentachlorobiphenyl	"2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of JAK3 protein"	16778083
C417207	2,2',4,6,6'-pentachlorobiphenyl	"PD168393 inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of JAK3 protein]"	16778083
C524063	2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one	"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [OSM protein results in increased phosphorylation of JAK3 protein]"	21548952
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of JAK3 mRNA	16788091
C562244	3-(5-(4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl)-2-trifluoromethylphenyl)-4-(1H-indol-3-yl)pyrrole-2,5-dione	"3-(5-(4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl)-2-trifluoromethylphenyl)-4-(1H-indol-3-yl)pyrrole-2,5-dione results in decreased activity of JAK3 protein"	21155605
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of JAK3 mRNA	22230336\|2669055
D000082	Acetaminophen	Acetaminophen affects the expression of JAK3 mRNA	17562736
C016601	afimoxifene	JAK3 results in decreased susceptibility to afimoxifene	21233418
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK3 protein"	25061499
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of JAK3 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of JAK3 gene	25304211
C006632	arsenic trioxide	[arsenic trioxide co-treated with decitabine] results in decreased expression of JAK3 mRNA	24762999
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of JAK3 mRNA	24762999
C000596027	baricitinib	baricitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK3 protein]	23968543
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of JAK3 mRNA	26377693
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of JAK3 mRNA	26377693
D004958	Estradiol	Estradiol results in increased expression of JAK3 mRNA	15289156
C006780	bisphenol A	bisphenol A affects the expression of JAK3 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of JAK3 mRNA	12160620
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of JAK3 promoter	22457795
D060729	Coal Ash	Coal Ash results in decreased expression of JAK3 mRNA	19000753
D003474	Curcumin	Curcumin results in decreased activity of JAK3 protein	16932349
D003474	Curcumin	Curcumin results in decreased activity of JAK3 protein	26244872
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of JAK3 mRNA	24317228
C014347	decitabine	[arsenic trioxide co-treated with decitabine] results in decreased expression of JAK3 mRNA	24762999
C014347	decitabine	decitabine results in decreased expression of JAK3 mRNA	24762999
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of JAK3 mRNA	15766595
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of JAK3 mRNA	15289156
C026066	enterotoxin A, Staphylococcal	"JAK3 affects the reaction [enterotoxin A, Staphylococcal results in increased secretion of IL17A protein]"	26738536
C118739	entinostat	entinostat results in increased expression of JAK3 mRNA	27188386
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of JAK3 protein	22348037
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of JAK3 protein modified form	22348037
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of JAK3 gene	16724327
D005419	Flavonoids	Flavonoids results in increased expression of JAK3 mRNA	18035473
D019833	Genistein	Genistein results in increased expression of JAK3 mRNA	15289156
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of JAK3 mRNA	19376150
C545385	Mequindox	Mequindox results in increased expression of JAK3 mRNA	21146578
D008694	Methamphetamine	Methamphetamine results in increased expression of JAK3 mRNA	26307267
D008727	Methotrexate	Methotrexate results in decreased expression of JAK3 mRNA	17400583
D008774	Methylphenidate	Methylphenidate results in decreased expression of JAK3 mRNA	22470460
C406082	monomethylarsonous acid	monomethylarsonous acid inhibits the reaction [IL7 protein results in increased phosphorylation of JAK3 protein]	26921788
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased phosphorylation of JAK3 protein	26518055
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of JAK3 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of JAK3 mRNA"	25554681\|2562005
D009532	Nickel	Nickel results in increased expression of JAK3 mRNA	25583101
C509204	PD168393	"PD168393 inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of JAK3 protein]"	16778083
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in increased expression of JAK3 mRNA	28973697
C554945	PF 956980	PF 956980 inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK3 protein]	23968543
C554945	PF 956980	PF 956980 results in decreased activity of JAK3 protein	23968543
D015232	Dinoprostone	Dinoprostone results in decreased phosphorylation of and results in decreased activity of JAK3 protein	19812686
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of JAK3 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of JAK3 mRNA	19710929
C545373	ponatinib	ponatinib results in decreased activity of JAK3 protein	19878872
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of JAK3 mRNA	25895662
C017947	sodium arsenite	sodium arsenite inhibits the reaction [IL7 protein results in increased phosphorylation of JAK3 protein]	26921788
C017947	sodium arsenite	sodium arsenite results in decreased phosphorylation of JAK3 protein	26518055
C061133	tamibarotene	tamibarotene results in decreased expression of JAK3 mRNA	20861477
D013629	Tamoxifen	Tamoxifen results in increased expression of JAK3 mRNA	19031437
C004648	testosterone enanthate	testosterone enanthate results in increased expression of JAK3 mRNA	25603467
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of JAK3 mRNA	21570461
C402769	tipifarnib	tipifarnib results in increased expression of JAK3 mRNA	16403772
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of JAK3 mRNA	28065790
C479163	tofacitinib	tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK3 protein]	23968543
C479163	tofacitinib	tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK3 protein]	21548952
C479163	tofacitinib	tofacitinib results in decreased activity of JAK3 protein	23689514\|2488333
C479163	tofacitinib	tofacitinib results in decreased activity of JAK3 protein	21155605\|2184413
D014118	Toxins, Biological	"Toxins, Biological affects the expression of JAK3 mRNA"	19682533
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of JAK3 mRNA"	26179874
C101044	tyrphostin AG 1478	tyrphostin AG 1478 results in decreased phosphorylation of and results in decreased activity of JAK3 protein	16932349
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAK3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of JAK3 mRNA	26272509
D014639	Vanadium	Vanadium results in decreased expression of JAK3 mRNA	19000753
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of JAK3 gene	25560391
C116180	WHI P131	WHI P131 results in decreased phosphorylation of and results in decreased activity of JAK3 protein	16932349
C116180	WHI P131	WHI P131 results in decreased activity of JAK3 protein	14615384
C113888	WHI P154	WHI P154 results in decreased phosphorylation of and results in decreased activity of JAK3 protein	16932349
C113888	WHI P154	WHI P154 results in decreased activity of JAK3 protein	11173405
C118361	WHI P180	WHI P180 results in decreased activity of JAK3 protein	11173405
D015032	Zinc	Zinc results in increased expression of JAK3 mRNA	19071009
C088658	zoledronic acid	zoledronic acid results in increased expression of JAK3 mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004713	protein tyrosine kinase activity	-	ISS	-
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005515	protein binding	-	IPI	9045636 25852190
GO:0005524	ATP binding	-	IEA	-
GO:0019903	protein phosphatase binding	-	IPI	11909529

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0002250	adaptive immune response	-	IEA	-
GO:0002731	negative regulation of dendritic cell cytokine production	-	ISS	-
GO:0006468	protein phosphorylation	-	TAS	8022790
GO:0007167	enzyme linked receptor protein signaling pathway	-	ISS	-
GO:0007260	tyrosine phosphorylation of STAT protein	-	IBA	21873635
GO:0007260	tyrosine phosphorylation of STAT protein	-	TAS	19290934
GO:0018108	peptidyl-tyrosine phosphorylation	-	ISS	-
GO:0019221	cytokine-mediated signaling pathway	-	IBA	21873635
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030183	B cell differentiation	-	IBA	21873635
GO:0030183	B cell differentiation	-	ISS	-
GO:0030218	erythrocyte differentiation	-	IBA	21873635
GO:0032693	negative regulation of interleukin-10 production	-	ISS	-
GO:0032695	negative regulation of interleukin-12 production	-	ISS	-
GO:0035556	intracellular signal transduction	-	ISS	-
GO:0035723	interleukin-15-mediated signaling pathway	-	TAS	-
GO:0035771	interleukin-4-mediated signaling pathway	-	IDA	7538655
GO:0038110	interleukin-2-mediated signaling pathway	-	TAS	-
GO:0038111	interleukin-7-mediated signaling pathway	-	TAS	-
GO:0038113	interleukin-9-mediated signaling pathway	-	TAS	-
GO:0038114	interleukin-21-mediated signaling pathway	-	TAS	-
GO:0042102	positive regulation of T cell proliferation	-	IBA	21873635
GO:0042981	regulation of apoptotic process	-	IBA	21873635
GO:0043029	T cell homeostasis	-	IBA	21873635
GO:0043029	T cell homeostasis	-	ISS	-
GO:0043029	T cell homeostasis	-	TAS	19290934
GO:0045221	negative regulation of FasL biosynthetic process	-	ISS	-
GO:0045626	negative regulation of T-helper 1 cell differentiation	-	ISS	-
GO:0046425	regulation of JAK-STAT cascade	-	TAS	19290934
GO:0050868	negative regulation of T cell activation	-	ISS	-
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	-	TAS	19290934
GO:0070232	regulation of T cell apoptotic process	-	ISS	-
GO:0070244	negative regulation of thymocyte apoptotic process	-	ISS	-
GO:0070669	response to interleukin-2	-	TAS	9973401
GO:0070670	response to interleukin-4	-	IDA	7538655 7594533
GO:0070672	response to interleukin-15	-	TAS	7594533
GO:0071104	response to interleukin-9	-	TAS	7594533

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005768	endosome	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	IEA	-

KEGG ID	KEGG Term
hsa04062	Chemokine signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa05340	Primary immunodeficiency

Reactome ID	Reactome Term	Evidence
R-HSA-1266695	Interleukin-7 signaling	TAS
R-HSA-1266695	Interleukin-7 signaling	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	TAS
R-HSA-397795	G-protein beta:gamma signalling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-449147	Signaling by Interleukins	IEA
R-HSA-451927	Interleukin-2 family signaling	TAS
R-HSA-451927	Interleukin-2 family signaling	IEA
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-8854691	Interleukin-20 family signaling	TAS
R-HSA-8983432	Interleukin-15 signaling	TAS
R-HSA-8983432	Interleukin-15 signaling	IEA
R-HSA-8985947	Interleukin-9 signaling	TAS
R-HSA-9020558	Interleukin-2 signaling	TAS
R-HSA-9020958	Interleukin-21 signaling	TAS
R-HSA-912526	Interleukin receptor SHC signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27003425	Inflammatory and Immune Response Genes Polymorphisms are Associated with Susceptibility to Chronic Obstructive Pulmonary Disease in Tatars Population from Russia. (2016 Aug)	Korytina GF	Biochem Genet