Gene info: ID 3727

Gene: JUND

GENE ID: 3727

Synonyms: AP-1

Description: JunD proto-oncogene, AP-1 transcription factor subunit

Gene type: protein-coding

Location: 19p13.11

dbXrefs: Ensembl:ENSG00000130522 MIM:165162 Vega:OTTHUMG00000183355 UniprotKB:P17535

RefSeq: NC_000019.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.708e-1 (AD) 9.882e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
R3HDM4	0.864
ARL6IP4	0.856
TMUB1	0.85
ZNF358	0.848
MZT2B	0.846
ABHD17A	0.843
PFDN2	0.839
C9orf16	0.837
MRPL41	0.834
UBE2M	0.831

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.759
OR4F29	-0.748
SLX4IP	-0.204
USP37	-0.169
SFTA2	-0.169
APOOL	-0.163
TSSK4	-0.161
ZC3H11B	-0.152
MTX3	-0.145
PRSS37	-0.144

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C031903	1-UFT protocol	JUND protein results in increased susceptibility to 1-UFT protocol	16734730
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of JUND mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of JUND mRNA"	27291303
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of JUND mRNA"	11509743
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of JUND mRNA"	11509743
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of JUND mRNA"	21346803
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of JUND mRNA	25088246
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of JUND protein	19464336
C031278	2-chloroethyl ethyl sulfide	[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of JUND protein]	19464336
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased activity of JUND protein	18675330
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased expression of JUND protein	18675330
C029536	2-oxothiazolidine-4-carboxylic acid	2-oxothiazolidine-4-carboxylic acid results in decreased expression of JUND mRNA	11230805
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone promotes the reaction [JUND protein binds to CYP2C9 promoter]	24830941
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone promotes the reaction [JUND protein modified form binds to CYP2C9 promoter]	24830941
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased phosphorylation of JUND protein	24830941
C018855	2-tert-butylhydroquinone	JUND mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]	24830941
C018855	2-tert-butylhydroquinone	pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of JUND protein]	24830941
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of JUND mRNA"	23196670
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of JUND mRNA"	19561079
C108123	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased activity of JUND protein]"	15772366
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of JUND mRNA	12419474
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]	9890986
C027576	4-hydroxy-2-nonenal	FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]	9890986
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of JUND mRNA"	26238291
D000082	Acetaminophen	Acetaminophen results in increased expression of JUND mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of JUND mRNA	15606129\|1756273
D000111	Acetylcysteine	[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of JUND protein]	19464336
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of JUND mRNA"	23195993
D024502	alpha-Tocopherol	[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of JUND protein]	19464336
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of JUND mRNA	16483693
D003913	Dextroamphetamine	[Phencyclidine co-treated with Dextroamphetamine] results in increased expression of JUND protein	16678866
D000661	Amphetamine	Amphetamine promotes the reaction [JUND protein binds to FOSL2 protein]	15814102
D000661	Amphetamine	Amphetamine results in decreased expression of JUND protein	15814102
D000661	Amphetamine	Amphetamine results in increased activity of [JUND protein binds to FOSL2 protein]	15814102
D000667	Ampicillin	Ampicillin results in increased expression of JUND mRNA	21632981
D000728	Androgens	Androgens results in increased expression of JUND protein	15486991
D000841	Anisomycin	Anisomycin results in increased expression of JUND mRNA	18241849
C006632	arsenic trioxide	[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein	17077332
C006632	arsenic trioxide	arsenic trioxide results in increased expression of JUND mRNA	15761015
D001241	Aspirin	Aspirin results in decreased expression of JUND mRNA	14976132
D001280	Atrazine	Atrazine results in increased expression of JUND mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of JUND mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of JUND mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [JUND protein binds to GSTA1 gene]	11961136
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of JUND mRNA	27195522
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of JUND mRNA	22300585
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JUND mRNA"	20018196
D004958	Estradiol	Estradiol affects the expression of JUND mRNA	14699072
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to JUND promoter]	23019147
D004958	Estradiol	"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of JUND mRNA"	11509743
D004958	Estradiol	[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of JUND mRNA	11509743
D004958	Estradiol	Estradiol results in increased expression of JUND mRNA	25210133
C006780	bisphenol A	bisphenol A promotes the reaction [ESR1 protein binds to JUND promoter]	23019147
C006780	bisphenol A	bisphenol A affects the methylation of JUND promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of JUND mRNA	25594700
C006780	bisphenol A	bisphenol A affects the expression of JUND mRNA	25181051
D000069286	Bortezomib	Bortezomib results in decreased expression of JUND mRNA	20977926
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of JUND mRNA	22079614
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of JUND mRNA	12419474
D002087	Butyrates	Butyrates results in increased expression of JUND mRNA	14674679
C584509	C646 compound	C646 compound results in decreased expression of JUND mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of JUND mRNA	21694771
D019256	Cadmium Chloride	MT3 affects the reaction [Cadmium Chloride affects the expression of JUND mRNA]	20371981
D002211	Capsaicin	Capsaicin results in increased expression of JUND mRNA	16278290
D002251	Carbon Tetrachloride	JUND gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]	17133482
D002251	Carbon Tetrachloride	JUND gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]	17133482
C100187	chloropicrin	chloropicrin results in increased expression of JUND mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of JUND gene	20938992
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of JUND mRNA	17178418
D002994	Clofibrate	Clofibrate results in decreased expression of JUND mRNA	16081524
D003024	Clozapine	Clozapine results in decreased expression of JUND mRNA	12093589
D003042	Cocaine	Cocaine results in decreased expression of JUND protein	15814102
D003042	Cocaine	[JUND protein results in decreased activity of FOSB protein] which results in decreased susceptibility to Cocaine	20056891
D019327	Copper Sulfate	Copper Sulfate results in increased expression of JUND mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUND protein]	17148446
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of JUND mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in increased expression of JUND mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of JUND protein	10617104
C014347	decitabine	[decitabine co-treated with Depsipeptides] results in increased expression of JUND mRNA	17064661
D013759	Dronabinol	Dronabinol results in increased expression of and results in increased localization of JUND protein	18454173
D013759	Dronabinol	Dronabinol results in increased expression of JUND mRNA	18454173
D013759	Dronabinol	JUND mutant form inhibits the reaction [Dronabinol results in increased expression of CDKN1B mRNA]	18454173
D013759	Dronabinol	JUND mutant form inhibits the reaction [Dronabinol results in increased expression of TES mRNA]	18454173
D013759	Dronabinol	JUND results in increased susceptibility to Dronabinol	18454173
D013759	Dronabinol	TES mutant form inhibits the reaction [Dronabinol results in increased expression of JUND mRNA]	18454173
D013759	Dronabinol	JUND results in increased susceptibility to Dronabinol	18454173
C479072	delta-tocopherol	[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of JUND protein]	19464336
C007262	deoxynivalenol	deoxynivalenol results in increased expression of JUND mRNA	22846391
C007262	deoxynivalenol	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased activity of JUND protein]"	15772366
C007262	deoxynivalenol	deoxynivalenol affects the activity of JUND protein	10662601
C007262	deoxynivalenol	deoxynivalenol affects the localization of JUND protein	12604842
C007262	deoxynivalenol	deoxynivalenol results in increased activity of JUND protein	15772366
D047630	Depsipeptides	[decitabine co-treated with Depsipeptides] results in increased expression of JUND mRNA	17064661
D047630	Depsipeptides	Depsipeptides results in increased expression of JUND mRNA	17064661
D003976	Diazinon	Diazinon results in increased methylation of JUND gene	22964155
D003976	Diazinon	Diazinon affects the expression of JUND mRNA	22546817
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of JUND mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of JUND mRNA	27594783
D004008	Diclofenac	Diclofenac results in increased expression of JUND mRNA	19022234
D004008	Diclofenac	Diclofenac results in increased expression of JUND mRNA	19022234
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of JUND mRNA	26924002
D004026	Dieldrin	Dieldrin affects the expression of JUND mRNA	22546817
D002117	Calcitriol	Calcitriol results in decreased expression of JUND mRNA	16002434
C062856	dimethylarsine	dimethylarsine results in increased phosphorylation of and results in increased activity of JUND protein	12475910
D004280	Dobutamine	Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]	15179140
D004280	Dobutamine	Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]	15179140
D004280	Dobutamine	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]	15179140
D004281	Docosahexaenoic Acids	[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein	17077332
D007980	Levodopa	Levodopa results in increased expression of JUND mRNA	17055656
D004391	Dust	Dust results in increased expression of JUND mRNA	17805423
D004642	Emodin	[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein	17077332
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of JUND mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of JUND mRNA	14976129
D015725	Fluconazole	Fluconazole results in decreased expression of JUND mRNA	16643972
D005485	Flutamide	Flutamide results in decreased expression of JUND mRNA	11509743
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of JUND gene	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of JUND mRNA	20655997
C007789	fucoidan	fucoidan results in decreased activity of JUND protein	16201850
C069837	fullerene C60	fullerene C60 results in increased expression of JUND mRNA	19167457
C056933	fumonisin B1	fumonisin B1 results in increased expression of JUND mRNA	16221962
C039281	furan	furan results in decreased expression of JUND mRNA	26194646
D024504	gamma-Tocopherol	[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of JUND protein]	19464336
D019833	Genistein	Genistein promotes the reaction [ESR1 protein binds to JUND promoter]	23019147
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased activity of JUND protein]	17925024
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in increased expression of JUND mRNA	16206274
C465546	green tea extract AR25	green tea extract AR25 promotes the reaction [JUND protein binds to CYP1A2 enhancer]	10620351
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of JUND mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of JUND mRNA	12419474
D007529	Isoflavones	Isoflavones results in increased expression of JUND mRNA	17374662
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of JUND mRNA	23086925
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of JUND mRNA	24796395\|2625444
C045463	leflunomide	leflunomide results in increased expression of JUND mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of and results in increased activity of JUND protein	10755711
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of JUND mRNA	26582142
D047311	Luteolin	Luteolin results in decreased activity of JUND protein	16343431
D008687	Metformin	Metformin results in increased expression of JUND mRNA	19022234
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of JUND gene	20938992
D008731	Methoxychlor	[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of JUND mRNA	11509743
D008731	Methoxychlor	Methoxychlor metabolite results in decreased expression of JUND mRNA	11509743
C080197	methylarsine oxide	methylarsine oxide results in increased phosphorylation of and results in increased activity of JUND protein	12475910
D008790	Metoprolol	Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]	15179140
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of JUND mRNA	26924002
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of JUND mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA	16357179
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of JUND mRNA"	29244179
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]	15179140
C051752	nefazodone	nefazodone results in decreased expression of JUND mRNA	24136188
D009532	Nickel	Nickel results in increased expression of JUND mRNA	23195993
C022838	nickel chloride	nickel chloride affects the expression of JUND mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in increased expression of JUND mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of JUND mRNA	19131640
C063998	nodularin	nodularin results in increased expression of JUND mRNA	27061667
C063998	nodularin	sauchinone inhibits the reaction [nodularin results in increased expression of JUND mRNA]	27061667
C464660	obeticholic acid	NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]	15860571
C507134	ON 01910	ON 01910 results in increased expression of JUND mRNA	22351695
D065108	Ornithine Decarboxylase Inhibitors	ELAVL1 protein promotes the reaction [Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]]	20805360
D065108	Ornithine Decarboxylase Inhibitors	ELAVL1 protein promotes the reaction [Ornithine Decarboxylase Inhibitors promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]]	20805360
D065108	Ornithine Decarboxylase Inhibitors	ELAVL1 protein promotes the reaction [Ornithine Decarboxylase Inhibitors results in increased expression of JUND protein]	20805360
D065108	Ornithine Decarboxylase Inhibitors	ELAVL1 protein promotes the reaction [Ornithine Decarboxylase Inhibitors results in increased stability of JUND mRNA]	20805360
D065108	Ornithine Decarboxylase Inhibitors	Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]	20805360
D065108	Ornithine Decarboxylase Inhibitors	Ornithine Decarboxylase Inhibitors promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]	20805360
D065108	Ornithine Decarboxylase Inhibitors	[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]	20805360
D065108	Ornithine Decarboxylase Inhibitors	[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]	20805360
D065108	Ornithine Decarboxylase Inhibitors	[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in increased expression of JUND protein	20805360
D065108	Ornithine Decarboxylase Inhibitors	[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in increased stability of JUND mRNA	20805360
D065108	Ornithine Decarboxylase Inhibitors	Ornithine Decarboxylase Inhibitors results in increased expression of JUND protein	20805360
D065108	Ornithine Decarboxylase Inhibitors	Ornithine Decarboxylase Inhibitors results in increased stability of JUND mRNA	20805360
D065108	Ornithine Decarboxylase Inhibitors	Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]]	20805360
D065108	Ornithine Decarboxylase Inhibitors	Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]]	20805360
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of JUND mRNA	25729387
D010269	Paraquat	Paraquat results in increased expression of JUND mRNA	18198484
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of JUND mRNA	18593933
D010424	Pentobarbital	Pentobarbital results in decreased expression of JUND protein	8510500
D010575	Pesticides	Pesticides results in decreased methylation of JUND gene	28396702
D010622	Phencyclidine	[Phencyclidine co-treated with Dextroamphetamine] results in increased expression of JUND protein	16678866
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of JUND mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of JUND mRNA	19482888
D010656	Phenylephrine	JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]	16690042
D010656	Phenylephrine	Phenylephrine results in decreased expression of JUND mRNA	16690042
D010695	Phlorhizin	Phlorhizin results in increased expression of JUND mRNA	22538082
C018637	phorone	phorone results in increased expression of JUND mRNA	11841787
C008911	pimaric acid	[pimaric acid co-treated with TNF protein] results in decreased expression of JUND protein	22705379
C006253	pirinixic acid	pirinixic acid results in increased expression of JUND mRNA	18445702
D010894	Piroxicam	Piroxicam results in decreased expression of JUND mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in decreased expression of JUND mRNA	23557933
D011073	Polyamines	[ODC1 protein results in increased chemical synthesis of Polyamines] inhibits the reaction [ELAVL1 protein binds to JUND 3' UTR]	20805360
D011073	Polyamines	[ODC1 protein results in increased chemical synthesis of Polyamines] promotes the reaction [HNRNPD protein binds to JUND 3' UTR]	20805360
D011073	Polyamines	[ODC1 protein results in increased chemical synthesis of Polyamines] which results in decreased expression of JUND protein	20805360
D011073	Polyamines	[ODC1 protein results in increased chemical synthesis of Polyamines] which results in decreased stability of JUND mRNA	20805360
D011073	Polyamines	[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]	20805360
D011073	Polyamines	[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]	20805360
D011073	Polyamines	[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in increased expression of JUND protein	20805360
D011073	Polyamines	[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in increased stability of JUND mRNA	20805360
D011073	Polyamines	Polyamines deficiency inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]	20805360
D011073	Polyamines	Polyamines deficiency promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]	20805360
D011073	Polyamines	Polyamines deficiency results in increased stability of JUND mRNA	20805360
C467566	pomalidomide	pomalidomide results in decreased expression of JUND mRNA	15292067
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of JUND protein	23718831
D011374	Progesterone	Progesterone results in increased expression of JUND mRNA	18037150
C550005	prothioconazole	prothioconazole results in increased expression of JUND mRNA	28263823
D011700	Putrescine	Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]]	20805360
D011700	Putrescine	Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors promotes the reaction [ELAVL1 protein binds to JUND 3' UTR]]	20805360
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of JUND protein]	24830941
D011794	Quercetin	Quercetin promotes the reaction [JUND protein binds to CYP1A2 enhancer]	10620351
D011794	Quercetin	Quercetin results in increased expression of JUND mRNA	21632981
C005266	quinomethionate	quinomethionate affects the expression of JUND mRNA	15387888
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the expression of JUND mRNA	25800948
C059514	resveratrol	resveratrol results in increased expression of JUND mRNA	15767336\|1662424
C009166	retinol acetate	retinol acetate results in increased expression of JUND mRNA	16772331
D012402	Rotenone	Rotenone promotes the reaction [JUND protein binds to FTH1 enhancer]	18325346
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of JUND mRNA	21427059
C410958	sauchinone	sauchinone inhibits the reaction [nodularin results in increased expression of JUND mRNA]	27061667
C078903	seocalcitol	seocalcitol results in decreased expression of JUND mRNA	12040012
D020280	Sertraline	Sertraline results in increased expression of JUND mRNA	24865413
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of JUND mRNA	19073995\|2322117
C009277	sodium arsenate	sodium arsenate results in increased expression of JUND mRNA	11353140
C017947	sodium arsenite	sodium arsenite results in increased activity of JUND protein	12220541
C017947	sodium arsenite	sodium arsenite results in increased expression of JUND mRNA	12760830
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of and results in increased activity of JUND protein	12475910
C017947	sodium arsenite	sodium arsenite results in increased expression of JUND mRNA	11353140
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of JUND mRNA	16214533
D013467	Sulindac	Sulindac results in increased expression of JUND mRNA	11906190
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of JUND mRNA"	26680231
C446685	systhane	systhane results in increased expression of JUND mRNA	16643972
D013629	Tamoxifen	Tamoxifen affects the expression of JUND mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of JUND mRNA	20106945\|2149626
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of JUND mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] which results in increased expression of JUND mRNA	8917696
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of JUND mRNA	16611356\|2149626
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of JUND mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUND protein]	17148446
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [JUND protein binds to CYP1A2 enhancer]	10620351
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of JUND protein	17148446
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of JUND protein	11507057\|1875585
D013849	Thimerosal	Thimerosal results in decreased expression of JUND mRNA	27188386
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of JUND mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of JUND mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of JUND mRNA	17045167
D014212	Tretinoin	Tretinoin results in increased expression of JUND mRNA	16604517
C032910	triadimefon	triadimefon results in increased expression of JUND mRNA	16643972
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of JUND mRNA	26745549
D014241	Trichloroethylene	PPARA protein inhibits the reaction [Trichloroethylene results in increased expression of JUND protein]	15363585
D014241	Trichloroethylene	Trichloroethylene results in increased expression of JUND mRNA	15363585
C012589	trichostatin A	trichostatin A results in increased expression of JUND mRNA	15901671
D014415	Tunicamycin	Tunicamycin results in increased expression of JUND mRNA	17127020
D014425	Turpentine	Turpentine results in decreased expression of JUND mRNA	16044259
D014520	Urethane	Urethane results in increased expression of JUND mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of JUND mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of JUND gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of JUND mRNA	21427059
D014635	Valproic Acid	Valproic Acid results in increased expression of JUND mRNA	15901671
C100058	vanillin	vanillin results in decreased expression of JUND mRNA	17178418
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of JUND protein	19900534
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of JUND mRNA	19165385
C025643	vinclozolin	vinclozolin results in decreased expression of JUND mRNA	23034163
C025643	vinclozolin	vinclozolin results in increased expression of JUND mRNA	23869203
C111237	vorinostat	vorinostat results in decreased expression of JUND mRNA	27188386
D014873	Water Pollutants	Water Pollutants results in increased expression of JUND mRNA	23591932
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of JUND mRNA	18593933
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of JUND mRNA	16357179

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0003713	transcription coactivator activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	9989505 15044019 17577209 18671972 20102225 20195357 22327296 23784080 24029232 24647988 25609649 26496610
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0016922	ligand-dependent nuclear receptor binding	-	IEA	-
GO:0019899	enzyme binding	-	IPI	23382074
GO:0044212	transcription regulatory region DNA binding	-	IDA	1903194

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0002076	osteoblast development	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	1903194
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0007623	circadian rhythm	-	IEA	-
GO:0009314	response to radiation	-	IBA	21873635
GO:0009416	response to light stimulus	-	IEA	-
GO:0009612	response to mechanical stimulus	-	IBA	21873635
GO:0010033	response to organic substance	-	IBA	21873635
GO:0010941	regulation of cell death	-	IBA	21873635
GO:0032496	response to lipopolysaccharide	-	IBA	21873635
GO:0032870	cellular response to hormone stimulus	-	IBA	21873635
GO:0034097	response to cytokine	-	IBA	21873635
GO:0042127	regulation of cell proliferation	-	IBA	21873635
GO:0042493	response to drug	-	IBA	21873635
GO:0043434	response to peptide hormone	-	IEA	-
GO:0045597	positive regulation of cell differentiation	-	IBA	21873635
GO:0045669	positive regulation of osteoblast differentiation	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	10508860
GO:0051591	response to cAMP	-	IBA	21873635
GO:0051726	regulation of cell cycle	-	IBA	21873635
GO:0071277	cellular response to calcium ion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000785	chromatin	-	TAS	1903194
GO:0000790	nuclear chromatin	-	IBA	21873635
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	IBA	21873635
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IBA	21873635
GO:0032993	protein-DNA complex	-	IEA	-
GO:0035976	transcription factor AP-1 complex	-	IDA	10508860

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04380	Osteoclast differentiation

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21338584	Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain. (2011 Apr 18)	Taqi MM	Brain Res
26391109	Ageing, metabolism and cardiovascular disease. (2016 Apr 15)	Costantino S	J Physiol