Gene info: ID 3728

Gene: JUP

GENE ID: 3728

Synonyms: CTNNG|DP3|DPIII|PDGB|PKGB

Description: junction plakoglobin

Gene type: protein-coding

Location: 17q21.2

dbXrefs: Ensembl:ENSG00000173801 MIM:173325 Vega:OTTHUMG00000133494 UniprotKB:P14923

RefSeq: NG_009090.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.185e-1 (AD) 5.164e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GSN	0.849
CYP27A1	0.839
PMP22	0.815
PHF19	0.806
DDR1	0.789
LGALS3BP	0.784
EFHD1	0.782
WASF2	0.78
TMEM179B	0.779
ZHX2	0.773

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FREM3	-0.433
RTP1	-0.429
FBLN7	-0.427
GPR26	-0.418
PRSS12	-0.415
KLK5	-0.414
CRH	-0.413
CNTN5	-0.406
KLHL14	-0.406
KCNH5	-0.402

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C063609	1,2-dimethyl-4-nitrobenzene	"1,2-dimethyl-4-nitrobenzene results in increased expression of JUP mRNA"	19784758
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in increased expression of JUP mRNA"	20951181
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of JUP protein"	19464575
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of JUP mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of JUP protein"	25670856
D000082	Acetaminophen	Acetaminophen affects the expression of JUP mRNA	19784758
D000082	Acetaminophen	Acetaminophen results in decreased expression of JUP mRNA	19784758
D000082	Acetaminophen	Acetaminophen results in increased expression of JUP mRNA	19784758
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of JUP protein	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of JUP mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of JUP gene	25304211
D001280	Atrazine	Atrazine results in increased expression of JUP mRNA	22378314
D004958	Estradiol	Estradiol affects the expression of JUP mRNA	23557687
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of JUP mRNA	20660070
D004958	Estradiol	Estradiol results in decreased expression of JUP mRNA	16474171
C044887	beta-methylcholine	beta-methylcholine affects the expression of JUP mRNA	21179406
C095105	bexarotene	bexarotene results in increased expression of JUP mRNA	16648578
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of JUP mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of JUP mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of JUP mRNA	16474171
C006780	bisphenol A	bisphenol A results in increased expression of JUP mRNA	27685785
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of JUP mRNA	28628672
C006780	bisphenol A	bisphenol A affects the methylation of JUP promoter	27334623
C006780	bisphenol A	bisphenol A affects the expression of JUP mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of JUP mRNA	25181051
C006780	bisphenol A	[Fructose co-treated with bisphenol A] results in increased expression of JUP protein	26930160
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of JUP mRNA	28628672
D002065	Buspirone	Buspirone results in decreased expression of JUP mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of JUP mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in decreased expression of JUP mRNA	26079696
D002104	Cadmium	JUP protein binds to Cadmium	23896426
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of JUP mRNA	21297351
C043211	carvedilol	carvedilol results in decreased expression of JUP mRNA	16824628
C043211	carvedilol	carvedilol results in increased expression of JUP protein	16824628
D007631	Chlordecone	Chlordecone inhibits the reaction [CDH1 protein binds to JUP protein]	11695219
D002713	Chlorine	Chlorine results in increased expression of JUP mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of JUP mRNA	18636392
D002994	Clofibrate	Clofibrate results in decreased expression of JUP mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of JUP mRNA	19320972
D003042	Cocaine	Cocaine affects the expression of JUP mRNA	20187946
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of JUP mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of JUP mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of JUP mRNA	20106945\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of JUP mRNA	21163907
C017160	cypermethrin	cypermethrin results in decreased expression of JUP mRNA	22528246
C014347	decitabine	decitabine results in increased expression of JUP mRNA	16887905\|1897426
C014347	decitabine	decitabine results in increased expression of JUP protein	16887905\|1897426
C014347	decitabine	DNMT3A protein affects the reaction [decitabine results in increased expression of JUP mRNA]	16887905
C014347	decitabine	DNMT3B protein affects the reaction [decitabine results in increased expression of JUP protein]	16887905
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of JUP mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of JUP mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of JUP mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of JUP mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of JUP mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of JUP mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of JUP mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of JUP mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of JUP mRNA	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of JUP mRNA	12807726
D002117	Calcitriol	Calcitriol results in increased expression of JUP mRNA	26485663
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of JUP mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of JUP mRNA	20463971
C118739	entinostat	entinostat results in increased expression of JUP mRNA	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of JUP mRNA	20064776
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of JUP protein	23301498
D005632	Fructose	[Fructose co-treated with bisphenol A] results in increased expression of JUP protein	26930160
C069837	fullerene C60	fullerene C60 results in increased expression of JUP mRNA	19167457
D019833	Genistein	Genistein results in decreased expression of JUP mRNA	16474171\|1670574
D006046	Gold	Gold analog results in decreased expression of JUP protein	24780912
C027185	indirubin	indirubin results in increased expression of JUP mRNA	20951181
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of JUP mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of JUP mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of JUP mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JUP mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of JUP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of JUP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of JUP mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of JUP mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of JUP mRNA	24796395
D007854	Lead	JUP protein binds to Lead	23896426
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of JUP mRNA	20353558
D008731	Methoxychlor	Methoxychlor results in increased methylation of JUP gene	23303685
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of JUP mRNA"	20188158
D008777	Methyltestosterone	Methyltestosterone results in increased expression of JUP mRNA	29191790
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of JUP mRNA	26924002
C498045	NCX 4040	NCX 4040 results in increased cleavage of JUP protein	16282376
C051752	nefazodone	nefazodone results in decreased expression of JUP mRNA	24136188
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of JUP mRNA	12760830
C029938	nickel sulfate	nickel sulfate results in decreased expression of JUP mRNA	22714537
C012655	nimesulide	nimesulide results in decreased expression of JUP mRNA	24136188
D009578	Nitrobenzenes	Nitrobenzenes analog results in increased expression of JUP mRNA	19784758
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of JUP mRNA	18636392
D000073878	Palm Oil	Palm Oil results in increased expression of JUP mRNA	18042831
D052638	Particulate Matter	Particulate Matter results in decreased expression of JUP mRNA	22178795
D010634	Phenobarbital	Phenobarbital results in decreased expression of JUP mRNA	12807726
D010705	Phosgene	Phosgene affects the expression of JUP mRNA	16300373
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of JUP mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of JUP mRNA	17426115
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of JUP mRNA	16474171
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of JUP mRNA	22714537
D011374	Progesterone	Progesterone results in decreased expression of JUP mRNA	23018184
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of JUP mRNA	20660070
D011374	Progesterone	Progesterone affects the expression of JUP mRNA	17251523
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of JUP mRNA	24780913
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of JUP mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of JUP mRNA	25888808
C065299	S-allylcysteine	S-allylcysteine results in increased expression of JUP protein	17155983
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of JUP mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in decreased expression of JUP mRNA	12760830
C016766	sulforafan	sulforafan results in decreased expression of JUP mRNA	26833863
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of JUP mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of JUP mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of JUP mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of JUP mRNA	23690540
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in decreased expression of JUP mRNA	23690540
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of JUP mRNA	17035482\|1758670
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the localization of and results in decreased expression of JUP protein	12478657
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to JUP promoter]	23690540
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of JUP mRNA	12478657\|2369054
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in decreased expression of JUP mRNA	23690540
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JUP mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of JUP mRNA	19784758
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of JUP mRNA	28065790
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of JUP mRNA	19448997
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of JUP mRNA	16141432
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of JUP mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of JUP mRNA	22378314
D014520	Urethane	Urethane results in increased expression of JUP mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of JUP mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of JUP mRNA	23179753
D014638	Vanadates	Vanadates results in increased phosphorylation of JUP protein	12626337
C025643	vinclozolin	vinclozolin results in decreased expression of JUP mRNA	23034163
D015032	Zinc	JUP protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003713	transcription coactivator activity	-	IBA	21873635
GO:0003713	transcription coactivator activity	-	IDA	14661054
GO:0005198	structural molecule activity	-	NAS	22889254
GO:0005199	structural constituent of cell wall	-	IC	7650039
GO:0005515	protein binding	-	IPI	7650039 7890674 7983064 10801826 12370829 14661054 16189514 16917092 17098867 17353931 17510365 19060904 20859650 20936779 24965446 25225338 25241761 25416956 26496610 26871637
GO:0019901	protein kinase binding	-	IEA	-
GO:0019903	protein phosphatase binding	-	IBA	21873635
GO:0019903	protein phosphatase binding	-	IPI	8663237
GO:0035257	nuclear hormone receptor binding	-	IBA	21873635
GO:0042803	protein homodimerization activity	-	ISS	-
GO:0045294	alpha-catenin binding	-	IBA	21873635
GO:0045294	alpha-catenin binding	-	IPI	7650039 7890674 23136403
GO:0045296	cadherin binding	-	HDA	25468996
GO:0045296	cadherin binding	-	IBA	21873635
GO:0045296	cadherin binding	-	IPI	1639850 7650039
GO:0050839	cell adhesion molecule binding	-	IPI	17559062
GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	-	IC	17924338

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001954	positive regulation of cell-matrix adhesion	-	IGI	28115160
GO:0002159	desmosome assembly	-	IDA	22889254
GO:0002159	desmosome assembly	-	IMP	20859650
GO:0007016	cytoskeletal anchoring at plasma membrane	-	NAS	22889254
GO:0016477	cell migration	-	IMP	18937352
GO:0031424	keratinization	-	TAS	-
GO:0034332	adherens junction organization	-	TAS	-
GO:0042127	regulation of cell proliferation	-	IDA	17924338
GO:0042307	positive regulation of protein import into nucleus	-	IDA	10825188 14661054
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043537	negative regulation of blood vessel endothelial cell migration	-	IGI	28115160
GO:0045766	positive regulation of angiogenesis	-	IGI	28115160
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0050982	detection of mechanical stimulus	-	IDA	18937352
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IDA	14661054
GO:0051291	protein heterooligomerization	-	IEA	-
GO:0070268	cornification	-	TAS	-
GO:0071603	endothelial cell-cell adhesion	-	ISS	-
GO:0071681	cellular response to indole-3-methanol	-	IDA	10868478
GO:0072659	protein localization to plasma membrane	-	IMP	20859650
GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	-	IMP	17924338
GO:0086091	regulation of heart rate by cardiac conduction	-	IMP	17924338
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IC	14661054
GO:0098609	cell-cell adhesion	-	IDA	18937352
GO:0098609	cell-cell adhesion	-	IMP	20859650
GO:0098911	regulation of ventricular cardiac muscle cell action potential	-	IMP	17924338
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001533	cornified envelope	-	TAS	-
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	IMP	14661054
GO:0005737	cytoplasm	-	IMP	14661054
GO:0005829	cytosol	-	ISS	-
GO:0005856	cytoskeleton	-	ISS	-
GO:0005882	intermediate filament	-	IEA	-
GO:0005886	plasma membrane	-	IDA	14661054 20859650
GO:0005886	plasma membrane	-	TAS	-
GO:0005911	cell-cell junction	-	IDA	1639850 7650039 7983064 10460003 14661054
GO:0005913	cell-cell adherens junction	-	IBA	21873635
GO:0005913	cell-cell adherens junction	-	IDA	10403777
GO:0005915	zonula adherens	-	ISS	-
GO:0005916	fascia adherens	-	IEA	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0009898	cytoplasmic side of plasma membrane	-	ISS	-
GO:0014704	intercalated disc	-	IDA	22781308 22889254 23381804
GO:0015629	actin cytoskeleton	-	IEA	-
GO:0016327	apicolateral plasma membrane	-	IEA	-
GO:0016328	lateral plasma membrane	-	IEA	-
GO:0016342	catenin complex	-	IBA	21873635
GO:0016342	catenin complex	-	IDA	7650039
GO:0030018	Z disc	-	IEA	-
GO:0030056	hemidesmosome	NOT	ISS	-
GO:0030057	desmosome	-	IDA	1639850
GO:0032993	protein-DNA complex	-	IDA	14661054
GO:0035580	specific granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867
GO:0071665	gamma-catenin-TCF7L2 complex	-	IDA	14661054
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-

KEGG ID	KEGG Term
hsa05200	Pathways in cancer
hsa05221	Acute myeloid leukemia
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-418990	Adherens junctions interactions	TAS
R-HSA-421270	Cell-cell junction organization	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-446728	Cell junction organization	TAS
R-HSA-5218920	VEGFR2 mediated vascular permeability	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6805567	Keratinization	TAS
R-HSA-6809371	Formation of the cornified envelope	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22973861	Burden of stroke in Cambodia. (2013 Aug)	Loo KW	Int J Stroke
28185567	From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration. (2016 Nov 22)	Gomez-Cabrero D	BMC Bioinformatics