Gene: KARS

3735
CMTRIB|DFNB89|KARS1|KARS2|KRS
lysyl-tRNA synthetase
protein-coding
16q23.1
Ensembl:ENSG00000065427 MIM:601421 Vega:OTTHUMG00000137609 UniprotKB:Q15046
NG_028025.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.635e-1 (AD)  9.519e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF3I0.954
RPN10.949
SSR20.943
USP390.942
ILF20.94
HAX10.94
TAF70.938
PSMF10.936
PCBP20.933
COPZ10.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.798
OR4F29-0.759
OR6C74-0.209
P2RY14-0.203
KLRB1-0.183
HMHB1-0.178
C8orf74-0.173
TCL1A-0.169
DMRTC2-0.167
FANCD2OS-0.167

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00123L-LysineSmall Molecule56-87-1Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of KARS mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of KARS mRNA"27291303
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of KARS mRNA12958071
D000082AcetaminophenAcetaminophen results in decreased expression of KARS mRNA21420995|2570463
D020106AcrylamideAcrylamide results in increased expression of KARS mRNA28959563
D001280AtrazineAtrazine results in increased expression of KARS mRNA22378314
D004958EstradiolEstradiol promotes the reaction [KARS protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A affects the expression of KARS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of KARS mRNA26063408
C006780bisphenol Abisphenol A affects the expression of KARS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of KARS mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KARS gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of KARS mRNA23741332
C099555CD 437CD 437 results in decreased expression of KARS mRNA12958071
D019327Copper SulfateCopper Sulfate results in decreased expression of KARS mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of KARS mRNA23914054
D000431EthanolEthanol results in decreased expression of KARS protein19609968
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KARS protein20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KARS mRNA17555576|1794274
D005485FlutamideFlutamide results in increased expression of KARS mRNA24136188
D005839GentamicinsGentamicins results in increased expression of KARS protein22061828
D007213IndomethacinIndomethacin results in decreased expression of KARS mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KARS mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KARS mRNA23086925
C011890kojic acidkojic acid results in decreased expression of KARS mRNA16595896
D007854LeadLead results in decreased expression of KARS mRNA19921347
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of KARS protein24806433
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KARS mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of KARS mRNA19167457
D010416PentachlorophenolPentachlorophenol results in decreased expression of KARS mRNA24642059
D010416PentachlorophenolPentachlorophenol results in increased expression of KARS mRNA23892564
C009277sodium arsenatesodium arsenate results in increased expression of KARS mRNA16882884
D013629TamoxifenTamoxifen affects the expression of KARS mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KARS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KARS mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KARS mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of KARS mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of KARS mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KARS gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-NAS10952987  
GO:0003877ATP adenylyltransferase activity-IDA23159739  
GO:0004824lysine-tRNA ligase activity-IDA9278442  10952987  23159739  
GO:0004824lysine-tRNA ligase activity-TAS-  
GO:0005515protein binding-IPI16189514  21220307  21536907  21900206  21988832  22386318  
23159739  24212136  24983501  25416956  
GO:0005524ATP binding-IEA-  
GO:0016597amino acid binding-IEA-  
GO:0042802identical protein binding-IPI18272479  21536907  24212136  
GO:0042803protein homodimerization activity-IPI23159739  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IDA15851690  
GO:0002276basophil activation involved in immune response-IGI19524539  
GO:0002741positive regulation of cytokine secretion involved in immune response-IDA15851690  
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006430lysyl-tRNA aminoacylation-IDA9278442  10952987  23159739  
GO:0008033tRNA processing-NAS10952987  
GO:0008285negative regulation of cell proliferation-IDA15851690  
GO:0010165response to X-ray-IEA-  
GO:0010759positive regulation of macrophage chemotaxis-IDA15851690  
GO:0015966diadenosine tetraphosphate biosynthetic process-IDA23159739  
GO:0015966diadenosine tetraphosphate biosynthetic process-IGI19524539  
GO:0016032viral process-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-IDA15851690  
GO:0043032positive regulation of macrophage activation-IDA15851690  
GO:0045893positive regulation of transcription, DNA-templated-IGI19524539  
GO:0070371ERK1 and ERK2 cascade-IGI19524539  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA15851690  
GO:1900017positive regulation of cytokine production involved in inflammatory response-IDA15851690  
GO:1900745positive regulation of p38MAPK cascade-IDA15851690  
GO:1905050positive regulation of metallopeptidase activity-IDA15851690  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA15851690  
GO:0005634nucleus-IDA23159739  
GO:0005739mitochondrion-IDA10952987  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IDA19289464  23159739  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0017101aminoacyl-tRNA synthetase multienzyme complex-IDA19131329  
KEGG ID KEGG Term
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-2408517SeMet incorporation into proteinsIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-379726Mitochondrial tRNA aminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20593945Evaluation of behavioural change towards smoking in Turkish fathers having 0-1 year old infants during prenatal and postnatal periods. (2010)Karatay GAsian Pac J Cancer Prev
25655046The relationship between quality of life and the severity of psoriasis in Turkey. (2015 Apr)Cakmur HEur J Dermatol
28103968[Gene Expression and Clinical Characteristics of Molecular Targeted Therapy in Non-small Cell Lung Cancer Patients in Shandong]. (2017 Jan 20)Qiao XZhongguo Fei Ai Za Zhi