Gene: KCNA3

3738
HGK5|HLK3|HPCN3|HUKIII|KV1.3|MK3|PCN3
potassium voltage-gated channel subfamily A member 3
protein-coding
1p13.3
Ensembl:ENSG00000177272 MIM:176263 Vega:OTTHUMG00000034493 UniprotKB:P22001
NC_000001.11
PubMed|SNP Mapped
4   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.044e-1 (AD)  2.007e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2640480chr1:110670626 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1319782chr1:110668911 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2640482chr1:110667697 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2640487chr1:110664263 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07421287chr1:111218287KCNA34.200e-10Smoking27651444
cg00995520chr1:111218282KCNA31.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPS6KA60.825
KCNH10.806
STXBP50.792
HS6ST30.791
PAQR90.788
GABRG30.788
WDR120.787
ARHGAP200.787
GRM50.784
TRPC50.782

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STON2-0.513
ROM1-0.507
CSAG1-0.496
FXYD3-0.491
NFIA-0.483
MYL3-0.481
IMPA2-0.475
TMEM176A-0.474
RAB13-0.468
CDKN2C-0.468

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06637DalfampridineSmall Molecule504-24-5ApprovedTarget
ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of KCNA3 mRNA28522335
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of KCNA3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KCNA3 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KCNA3 gene28458013
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNA3 mRNA16483693
D001151ArsenicArsenic affects the methylation of KCNA3 gene25304211
D001558BenzethoniumBenzethonium results in decreased activity of KCNA3 protein21362439
D001558Benzethonium[Benzethonium results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
C006780bisphenol Abisphenol A results in decreased expression of KCNA3 mRNA25181051
C026690cerous chloridecerous chloride results in increased expression of KCNA3 mRNA23573234
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNA3 gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of KCNA3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KCNA3 mRNA]17585979
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of KCNA3 mRNA23640034
C007556domiphendomiphen results in decreased activity of KCNA3 protein21362439
C007556domiphen[domiphen results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D004464EconazoleEconazole results in decreased activity of KCNA3 protein21362439
D004464Econazole[Econazole results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of KCNA3 mRNA17347304
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of KCNA3 mRNA17347304
D005419FlavonoidsFlavonoids results in decreased expression of KCNA3 mRNA18035473
D005473FluoxetineFluoxetine results in decreased activity of KCNA3 protein17638537
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNA3 gene20938992
C435770gambierolgambierol analog results in decreased activity of KCNA3 protein25155189
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KCNA3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KCNA3 mRNA21889194
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of KCNA3 mRNA"24972896
C005095malachite greenmalachite green results in decreased activity of KCNA3 protein21362439
C005095malachite green[malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
C077910margatoxinmargatoxin results in decreased activity of KCNA3 protein17638537
C077910margatoxinmargatoxin inhibits the reaction [Methamphetamine results in increased expression of KCNA3 mRNA]24533129
C077910margatoxinmargatoxin inhibits the reaction [Methamphetamine results in increased expression of KCNA3 protein]24533129
D008694Methamphetaminemargatoxin inhibits the reaction [Methamphetamine results in increased expression of KCNA3 mRNA]24533129
D008694Methamphetaminemargatoxin inhibits the reaction [Methamphetamine results in increased expression of KCNA3 protein]24533129
D008694MethamphetamineMethamphetamine results in increased expression of KCNA3 mRNA24533129
D008694MethamphetamineMethamphetamine results in increased expression of KCNA3 protein24533129
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNA3 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KCNA3 mRNA"20188158
D009532NickelNickel results in increased expression of KCNA3 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of KCNA3 mRNA19167457
D009543NifedipineNifedipine results in decreased activity of KCNA3 protein17638537
C025256nonylphenolnonylphenol results in increased expression of KCNA3 mRNA22982499
C016340o,p'-DDT"o,p'-DDT results in decreased activity of KCNA3 protein"21362439
C016340o,p'-DDT"[o,p'-DDT results in decreased activity of KCNA3 protein] which results in decreased import of Thallium"21362439
D010705PhosgenePhosgene affects the expression of KCNA3 mRNA16300373
D012110ReserpineReserpine results in decreased activity of KCNA3 protein21362439
D012110Reserpine[Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D012604Scorpion VenomsScorpion Venoms results in decreased activity of KCNA3 protein17638537
C016766sulforafansulforafan results in decreased expression of KCNA3 mRNA26833863
D013629TamoxifenTamoxifen results in decreased activity of KCNA3 protein17638537|2136243
D013629Tamoxifen[Tamoxifen results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCNA3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KCNA3 mRNA16120747
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KCNA3 mRNA25613284
C520892tetraoctylammonium bromidetetraoctylammonium bromide results in decreased activity of KCNA3 protein21362439
C520892tetraoctylammonium bromide[tetraoctylammonium bromide results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium[Benzethonium results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium[domiphen results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium[Econazole results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium[malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium"[o,p'-DDT results in decreased activity of KCNA3 protein] which results in decreased import of Thallium"21362439
D013793Thallium[Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium[Tamoxifen results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium[tetraoctylammonium bromide results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium[Tritolyl Phosphates results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D013793Thallium[Verapamil results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D014317Tritolyl PhosphatesTritolyl Phosphates results in decreased activity of KCNA3 protein21362439
D014317Tritolyl Phosphates[Tritolyl Phosphates results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439
D014635Valproic AcidValproic Acid results in increased methylation of KCNA3 gene29154799
D014639VanadiumVanadium results in decreased expression of KCNA3 mRNA19000753
D014700VerapamilVerapamil results in decreased activity of KCNA3 protein21362439
D014700Verapamil[Verapamil results in decreased activity of KCNA3 protein] which results in decreased import of Thallium21362439

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-TAS1373731  
GO:0005249voltage-gated potassium channel activity-IBA21873635  
GO:0005251delayed rectifier potassium channel activity-IBA21873635  
GO:0005251delayed rectifier potassium channel activity-IEA-  
GO:0005515protein binding-IPI9341123  18818304  26871637  
GO:0015271outward rectifier potassium channel activity-IBA21873635  
GO:0015271outward rectifier potassium channel activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-TAS1373731  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO:0071435potassium ion export-IBA21873635  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0008076voltage-gated potassium channel complex-IBA21873635  
GO:0008076voltage-gated potassium channel complex-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0030424axon-IBA21873635  
GO:0030424axon-IEA-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296072Voltage gated Potassium channelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25129674Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. (2014 Sep)McClintick JNAlcohol