Gene: AREG

374
AR|AREGB|CRDGF|SDGF
amphiregulin
protein-coding
4q13.3
Ensembl:ENSG00000109321 MIM:104640 Vega:OTTHUMG00000130006 UniprotKB:P15514
NC_000004.12
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.649e-1 (AD)  1.937e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CA10.526
MS4A30.463
DEFA40.439
AHSP0.435
LSP10.425
SPTA10.424
CD300E0.42
KRTAP4-60.411
H3F3C0.403
TREM10.403

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS3ST5-0.298
LRRC38-0.284
E2F1-0.267
MAGIX-0.263
TCEANC-0.261
TULP4-0.26
FEZF2-0.254
SP9-0.253
RXFP1-0.247
ZNF385C-0.242

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0514521,2,3,7,8-pentachlorodibenzo-p-dioxin"1,2,3,7,8-pentachlorodibenzo-p-dioxin results in increased expression of AREG mRNA"16929009
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of AREG mRNA23792671
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of AREG mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AREG mRNA"27291303
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of AREG protein12589827
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of AREG mRNA"20406850
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of AREG mRNA]23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of AREG protein]23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of AREG mRNA23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased secretion of AREG protein23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AREG mRNA]23196670
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AREG mRNA"23196670
C0213383-hydroxybenzo(a)pyrene3-hydroxybenzo(a)pyrene results in increased expression of AREG mRNA26238291
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AREG mRNA"27188386
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine results in decreased secretion of AREG protein"15615697
C0554924-hydroxy-N-desmethyltamoxifen4-hydroxy-N-desmethyltamoxifen inhibits the reaction [Estradiol results in increased expression of AREG mRNA]19244106
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AREG mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of AREG mRNA"23625689
C1078756-(methylamino)pyrido(3,4-d)pyrimidine"6-(methylamino)pyrido(3,4-d)pyrimidine results in decreased secretion of AREG protein"15615697
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of AREG mRNA"19936915
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of AREG mRNA"26238291
C469552A 419259A 419259 inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of AREG protein]15342401
D000082AcetaminophenAcetaminophen results in decreased expression of AREG mRNA22230336|2669055
D000082AcetaminophenAcetaminophen affects the expression of AREG mRNA17562736
C016601afimoxifeneafimoxifene results in decreased expression of AREG mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AREG mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AREG mRNA19770486
D000393Air PollutantsAir Pollutants analog results in increased expression of AREG mRNA21757418
D000393Air PollutantsAir Pollutants results in increased secretion of AREG protein23159501
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AREG mRNA16483693
D001151ArsenicArsenic results in decreased expression of AREG mRNA19654921
C015001arsenitearsenite results in increased expression of AREG mRNA25543096
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of AREG mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of AREG mRNA"18687144
D001280Atrazine[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]23583632
D001280AtrazineU 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]]23583632
C080985batimastatbatimastat inhibits the reaction [pervanadate results in increased cleavage of AREG protein]9685416
C080985batimastatbatimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of AREG protein]27117977
C080985batimastatbatimastat results in decreased secretion of AREG protein27117977
C447119bazedoxifene"bazedoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]"19022889
C447119bazedoxifenebazedoxifene results in increased expression of AREG mRNA19022889
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of AREG mRNA22643241
C030935benz(a)anthracenebisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of AREG mRNA]]22643241
C030935benz(a)anthraceneTetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of AREG mRNA]22643241
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AREG mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AREG mRNA27858113
D001572BenzofuransBenzofurans analog results in increased expression of AREG mRNA16929009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AREG mRNA18061397|1918144
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AREG mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AREG mRNA21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AREG mRNA16929009|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of AREG mRNA"19150397|2038263
D004958Estradiol4-hydroxy-N-desmethyltamoxifen inhibits the reaction [Estradiol results in increased expression of AREG mRNA]19244106
D004958Estradiol[AREG protein co-treated with Estradiol] results in increased phosphorylation of EGFR protein21185374
D004958Estradiol[Cycloheximide co-treated with Estradiol] results in increased expression of AREG mRNA15072547
D004958EstradiolEstradiol affects the expression of AREG mRNA21826169
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of AREG mRNA24758408
D004958EstradiolEstradiol results in increased expression of AREG mRNA12432273|1507254
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of AREG mRNA]24758408
D004958Estradioltyrphostin AG 1478 inhibits the reaction [[AREG protein co-treated with Estradiol] results in increased phosphorylation of EGFR protein]21185374
D004958EstradiolValproic Acid promotes the reaction [Estradiol results in increased expression of AREG mRNA]19772891
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of AREG mRNA18556351
D004958EstradiolEstradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]22414604
D004958EstradiolEstradiol promotes the reaction [Progesterone inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]]22414604
D004958EstradiolEstradiol results in increased expression of AREG mRNA17450229|1855635
D004958EstradiolProgesterone promotes the reaction [Estradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]]22414604
D004958EstradiolEstradiol results in increased expression of AREG mRNA26372666
D004958Estradiol[Methylnitrosourea co-treated with Estradiol] results in increased expression of AREG mRNA20732338
D004958Estradiol[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of AREG mRNA20732338
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of AREG mRNA]21251947
D001663BilirubinBilirubin results in increased expression of AREG mRNA20196124
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of AREG mRNA]]22643241
C006780bisphenol Abisphenol A affects the expression of AREG mRNA21826169
C006780bisphenol Abisphenol A results in increased expression of AREG mRNA16474171|2871154
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AREG mRNA28628672
C006780bisphenol A[potassium bromate co-treated with bisphenol A] affects the expression of AREG mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AREG mRNA]27082013
C006780bisphenol Abisphenol A affects the expression of AREG mRNA25181051
D001761BleomycinBleomycin results in increased expression of AREG mRNA26817844
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of AREG mRNA20147733|2207961
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AREG mRNA12414654
C018475butyraldehydebutyraldehyde results in increased expression of AREG mRNA26079696
D002104CadmiumCadmium results in increased expression of AREG mRNA21694771
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AREG mRNA20061341
D002211CapsaicinEGFR gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of AREG mRNA]20660715
D002211Capsaicin[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of AREG mRNA20660715
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AREG mRNA27339419
D002746ChlorpromazineChlorpromazine results in decreased expression of AREG mRNA15924885
D002784CholesterolCholesterol results in increased expression of AREG mRNA26296894
D002784CholesterolCLEC4E protein promotes the reaction [Cholesterol results in increased expression of AREG mRNA]26296894
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AREG mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of AREG mRNA22915297
D002794CholineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of AREG mRNA]22915297
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AREG mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of AREG mRNA24386269
D005576ColforsinColforsin results in increased expression of AREG mRNA15284208|1531339
D005576ColforsinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG mRNA]15967414
D005576ColforsinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG protein]15967414
D005576ColforsinColforsin results in increased expression of AREG mRNA20378682
D019327Copper SulfateCopper Sulfate results in increased expression of AREG mRNA19549813
C015763cumene[cumene co-treated with KRAS gene mutant form] results in increased expression of AREG mRNA18648096
C030973cupric oxidecupric oxide results in decreased expression of AREG mRNA22077320
D003513Cycloheximide[Cycloheximide co-treated with Estradiol] results in increased expression of AREG mRNA15072547
D003513CycloheximideCycloheximide results in increased expression of AREG mRNA15072547|1522809
D016572CyclosporineCyclosporine results in increased expression of AREG mRNA19770486
D016572CyclosporineCyclosporine results in increased expression of AREG mRNA21865292
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in increased expression of AREG mRNA26854739
C014347decitabinedecitabine results in increased expression of AREG mRNA16367923|2185625
D013759DronabinolAREG inhibits the reaction [Dronabinol results in increased expression of NUPR1 mRNA]19229996
D013759DronabinolAREG inhibits the reaction [Dronabinol results in increased expression of TRIB3 mRNA]19229996
D013759DronabinolAREG results in decreased susceptibility to Dronabinol19229996
D003840Deoxycholic AcidDeoxycholic Acid results in increased secretion of AREG protein16213893
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AREG mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of AREG mRNA12837037
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AREG mRNA21266533
D002945CisplatinCisplatin results in increased expression of AREG protein20726858
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AREG mRNA26865669
D002117CalcitriolCalcitriol results in increased expression of AREG mRNA11237771|1499699
D002117CalcitriolIsotretinoin inhibits the reaction [Calcitriol results in increased expression of AREG mRNA]11237771
D002117CalcitriolCalcitriol results in increased expression of AREG mRNA15509566
D011397Promegestonegefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein]21258428
D011397Promegestonegefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein]21258428
D011397Promegestone[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein21258428
D011397Promegestone[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein21258428
D004237DiuronDiuron results in decreased expression of AREG mRNA21551480
C521792DMU-212DMU-212 affects the expression of AREG mRNA26428916
D004391DustDust results in increased secretion of AREG protein29319804
D000069347Erlotinib HydrochlorideAREG protein affects the susceptibility to Erlotinib Hydrochloride18980991
D004967EstrogensEstrogens affects the expression of AREG mRNA15473135
D004967EstrogensEstrogens affects the expression of AREG mRNA15473135
D004967EstrogensEstrogens promotes the reaction [Progesterone results in increased expression of AREG mRNA]21258428
D004967Estrogens[Progesterone co-treated with Estrogens] results in increased expression of AREG protein21258428
D004966Estrogens, Conjugated (USP)"bazedoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]"19022889
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) results in increased expression of AREG mRNA"19022889
D004966Estrogens, Conjugated (USP)"Lasofoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]"19022889
D004966Estrogens, Conjugated (USP)"Raloxifene Hydrochloride inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]"19022889
D004970EstroneEstrone results in increased expression of AREG mRNA26865669
D008656MestranolMestranol results in increased expression of AREG mRNA26865669
D005047EtoposideEtoposide results in increased expression of AREG mRNA15228094
D005047EtoposideEtoposide results in increased expression of AREG protein15228094
D005047EtoposideEtoposide results in decreased expression of AREG mRNA25270620
C056516exemestaneexemestane results in increased expression of AREG mRNA18677558
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of AREG mRNA17317680
D0150732-AcetylaminofluoreneTRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]17317680
D005472FluorouracilAREG affects the susceptibility to Fluorouracil15067352
D005472FluorouracilFluorouracil results in increased expression of AREG mRNA16709241
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of AREG mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AREG mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of AREG mRNA20655997|2893796
D005557FormaldehydeFormaldehyde results in increased expression of AREG mRNA18499655|2088468
C070081fulvestrantfulvestrant results in decreased expression of AREG mRNA16202921|1651462
C070081fulvestrantfulvestrant results in increased expression of AREG mRNA15072547
C039281furanfuran results in decreased methylation of AREG gene27387713
C039281furanfuran results in increased expression of AREG mRNA27387713
C419708gefitinibAREG protein affects the susceptibility to gefitinib18980991
C419708gefitinibAREG protein results in decreased susceptibility to gefitinib15496427|1623037
C419708gefitinibgefitinib inhibits the reaction [irinotecan metabolite results in increased expression of AREG mRNA]15723263
C419708gefitinibgefitinib inhibits the reaction [irinotecan results in increased expression of AREG mRNA]15723263
C419708gefitinibgefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK1 protein]21258428
C419708gefitinibgefitinib inhibits the reaction [[Promegestone co-treated with AREG protein] results in increased phosphorylation of MAPK3 protein]21258428
C056507gemcitabineADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein]20726858
C056507gemcitabineAREG protein results in decreased susceptibility to gemcitabine20726858
C056507gemcitabinegemcitabine results in increased cleavage of AREG protein20726858
C056507gemcitabinegemcitabine results in increased expression of AREG protein20726858
D019833GenisteinGenistein results in increased expression of AREG mRNA16474171|2686566
D019833GenisteinGenistein results in increased expression of AREG mRNA24365114
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in increased expression of AREG mRNA16206274
D006064Gonadotropins, Equine"[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of AREG mRNA"15831568
D006064Gonadotropins, Equine"Gonadotropins, Equine results in increased expression of AREG mRNA"15291759
D006118GriseofulvinGriseofulvin results in increased expression of AREG protein19267999
D006063Chorionic Gonadotropin"[Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of AREG mRNA"15831568
C010178heliotrineheliotrine results in increased expression of AREG mRNA26100227
C089796hexabromocyclododecanehexabromocyclododecane inhibits the reaction [[FSHB protein co-treated with CGA protein] results in increased expression of AREG mRNA]24071787
D006589HexestrolHexestrol results in increased expression of AREG mRNA26865669
D006851Hydrochloric AcidHydrochloric Acid results in decreased expression of AREG mRNA15046208
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of AREG mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of AREG mRNA12414654
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of AREG mRNA15072547
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of AREG mRNA"26377693
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of AREG mRNA"18061397
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AREG mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AREG mRNA25613284
C051890irinotecangefitinib inhibits the reaction [irinotecan metabolite results in increased expression of AREG mRNA]15723263
C051890irinotecangefitinib inhibits the reaction [irinotecan results in increased expression of AREG mRNA]15723263
C051890irinotecanirinotecan metabolite results in increased expression of AREG mRNA15723263
C051890irinotecanirinotecan results in increased expression of AREG mRNA15723263
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine results in increased expression of AREG mRNA15284208
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AREG mRNA28628672
C518329isopropyl-9H-thioxanthen-9-oneisopropyl-9H-thioxanthen-9-one results in increased expression of AREG mRNA20558275
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of AREG mRNA16835149
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of AREG mRNA17085751
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of AREG protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AREG mRNA25961927
C107086KB R7785KB R7785 inhibits the reaction [CXCL8 protein results in increased cleavage of and results in increased secretion of AREG protein]15300588
C111332Lasofoxifene"Lasofoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]"19022889
C111332LasofoxifeneLasofoxifene results in increased expression of AREG mRNA19022889
D008070LipopolysaccharidesLipopolysaccharides affects the expression of AREG mRNA28070326
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of AREG mRNA26667767
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of AREG mRNA]28070326
C039993loxtidineloxtidine results in decreased expression of AREG mRNA15940630
C039993loxtidine[YF 476 co-treated with loxtidine] results in decreased expression of AREG mRNA15940630
C100342marimastatmarimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of AREG protein]15342401
D008694MethamphetamineMethamphetamine results in decreased expression of AREG mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AREG mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of AREG mRNA22915297
D008715MethionineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of AREG mRNA]22915297
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of AREG mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of AREG mRNA24449571
D008727MethotrexateMethotrexate results in increased expression of AREG mRNA17379860|2167806
D008748MethylcholanthreneMethylcholanthrene results in increased expression of AREG mRNA16257430
D008748MethylcholanthreneMethylcholanthrene results in increased expression of AREG mRNA26372666
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AREG mRNA28001369
D008770Methylnitrosourea[Methylnitrosourea co-treated with Estradiol] results in increased expression of AREG mRNA20732338
D008770Methylnitrosourea[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of AREG mRNA20732338
D008770Methylnitrosourea[Methylnitrosourea co-treated with Progesterone] results in increased expression of AREG mRNA20732338
D015735MifepristoneMifepristone results in decreased expression of AREG mRNA18591650
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of AREG mRNA20886546
C500085muraglitazarmuraglitazar results in decreased expression of AREG mRNA21515302
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG mRNA]15967414
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG protein]15967414
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA]16888076
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased expression of AREG mRNA]15967414
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased expression of AREG protein]15967414
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased expression of AREG mRNA]15967414
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased expression of AREG protein]15967414
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AREG mRNA"25102311
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AREG mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AREG mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of AREG mRNA18978301
C031721naphthalenenaphthalene analog results in increased expression of AREG mRNA24976557
D009281NaphthalenesNaphthalenes results in increased expression of AREG protein17337753
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of AREG mRNA20551477
D009532NickelNickel results in increased expression of AREG mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of AREG mRNA22714537
C029938nickel sulfatenickel sulfate results in increased expression of AREG mRNA18651567
C029938nickel sulfatenickel sulfate results in increased expression of AREG mRNA16166746
C012655nimesulidenimesulide inhibits the reaction [LHB results in increased expression of AREG mRNA]16888076
C012655nimesulidenimesulide inhibits the reaction [LHB results in increased expression of AREG protein]16888076
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of AREG mRNA17616710
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of AREG mRNA27935865
C024713n-tetradecanen-tetradecane results in increased expression of AREG protein17337753
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of AREG mRNA25658374
D010126OzoneOzone results in increased expression of AREG mRNA17095637|1955522
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of AREG mRNA]19555225
D010126OzoneOzone results in increased expression of AREG mRNA16716893
D017239PaclitaxelPaclitaxel results in increased expression of AREG protein20726858
D052638Particulate MatterParticulate Matter results in increased expression of AREG mRNA21879948|2282075
D052638Particulate MatterParticulate Matter results in increased secretion of AREG protein22820758|2315950
D052638Particulate MatterTAPI-2 inhibits the reaction [Particulate Matter results in increased secretion of AREG protein]22820758
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of AREG mRNA18593933
C023036perfluorooctanoic acidEstradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]22414604
C023036perfluorooctanoic acidEstradiol promotes the reaction [Progesterone inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]]22414604
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AREG protein22414604
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AREG protein20118188
C023036perfluorooctanoic acidProgesterone inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]22414604
C023036perfluorooctanoic acidProgesterone promotes the reaction [Estradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]]22414604
C076715pervanadatebatimastat inhibits the reaction [pervanadate results in increased cleavage of AREG protein]9685416
C076715pervanadatepervanadate results in increased cleavage of AREG protein9685416
D015232DinoprostoneDinoprostone results in increased expression of AREG mRNA15284208|1688807
D015232DinoprostoneDinoprostone results in increased expression of AREG protein16888076
D015232DinoprostoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA]16888076
D015232DinoprostoneU 0126 inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA]16888076
D015232DinoprostoneDinoprostone results in increased expression of AREG mRNA15509566
D015232DinoprostoneDinoprostone promotes the reaction [CREB1 protein binds to AREG promoter]16088955
D015232DinoprostoneDinoprostone results in increased expression of AREG mRNA16088955
D010634PhenobarbitalPhenobarbital affects the expression of AREG mRNA19159669
D010656PhenylephrinePhenylephrine results in increased expression of AREG mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AREG mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AREG mRNA26272509
D010705PhosgenePhosgene affects the expression of AREG mRNA16300373
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of AREG mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of AREG mRNA17426115
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of AREG mRNA]28070326
D010936Plant ExtractsPlant Extracts results in increased expression of AREG mRNA18061397
D010938Plant OilsPlant Oils results in increased expression of AREG mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of AREG mRNA16474171
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of AREG mRNA27989595
D011137PolystyrenesPolystyrenes analog results in increased expression of AREG mRNA25102311
D011137PolystyrenesPolystyrenes results in increased expression of AREG mRNA25102311
C019536potassium bromatepotassium bromate affects the expression of AREG mRNA27082013
C019536potassium bromate[potassium bromate co-treated with bisphenol A] affects the expression of AREG mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of AREG mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AREG mRNA]27082013
D011374Progesterone[Progesterone affects the activity of PGR protein alternative form] which affects the expression of AREG mRNA15866122
D011374ProgesteroneProgesterone results in increased expression of AREG mRNA18070364
D011374ProgesteroneAREG protein results in increased abundance of Progesterone21047912
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of AREG mRNA18556351
D011374ProgesteroneEstradiol promotes the reaction [Progesterone inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]]22414604
D011374ProgesteroneNRG1 protein promotes the reaction [AREG protein results in increased abundance of Progesterone]21047912
D011374ProgesteroneProgesterone affects the expression of AREG15178747|1679400
D011374ProgesteroneProgesterone inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]22414604
D011374ProgesteroneProgesterone promotes the reaction [Estradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of AREG protein]]22414604
D011374ProgesteroneProgesterone results in decreased expression of AREG mRNA19690047
D011374ProgesteroneEstrogens promotes the reaction [Progesterone results in increased expression of AREG mRNA]21258428
D011374Progesterone[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of AREG mRNA20732338
D011374Progesterone[Methylnitrosourea co-treated with Progesterone] results in increased expression of AREG mRNA20732338
D011374Progesterone[Progesterone co-treated with Estrogens] results in increased expression of AREG protein21258428
D011374ProgesteroneProgesterone results in increased expression of AREG mRNA18591650|2125842
C005556propionaldehydepropionaldehyde results in increased expression of AREG mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of AREG mRNA24780913
D011524ProtoporphyrinsProtoporphyrins results in increased expression of AREG protein19267999
C010313pseudocumenepseudocumene results in increased expression of AREG protein17337753
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in increased expression of AREG mRNA26100227
D011794QuercetinQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of AREG mRNA]22915297
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AREG mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of AREG mRNA16514628|2686566
D020849Raloxifene Hydrochloride"Raloxifene Hydrochloride inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]"19022889
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of AREG mRNA19022889
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of AREG mRNA26667767
D012172RetinaldehydeRetinaldehyde results in increased expression of AREG mRNA16470170
D015474IsotretinoinIsotretinoin inhibits the reaction [Calcitriol results in increased expression of AREG mRNA]11237771
D020889RolipramRolipram results in increased expression of AREG mRNA15284208
C089730rosiglitazonerosiglitazone results in decreased expression of AREG mRNA21515302
C541923sandostatinLARsandostatinLAR results in increased expression of AREG mRNA17210224
C093642SB 203580SB 203580 results in decreased activity of AREG protein12589827
C009237senecioninesenecionine results in increased expression of AREG mRNA26100227
C009238senkirkinesenkirkine results in increased expression of AREG mRNA26100227
C078903seocalcitolseocalcitol results in increased expression of AREG mRNA12040012
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of AREG mRNA"21514415
D017632Asbestos, Serpentine"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of AREG mRNA]"21514415
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of AREG mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of AREG mRNA19073995
D012834SilverSilver results in increased expression of AREG mRNA27131904
D012906SmokeSmoke results in decreased nitrosation of AREG protein21652289
C017947sodium arsenitesodium arsenite results in increased expression of AREG mRNA16014739
C016104sodium bichromatesodium bichromate results in increased expression of AREG mRNA22561333
C016104sodium bichromatesodium bichromate results in decreased expression of AREG mRNA22561333
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased secretion of AREG protein17763283
D012969Sodium FluorideSodium Fluoride results in increased expression of AREG mRNA27257137
D053260SootSoot results in increased expression of AREG mRNA22461453|2655175
D019311StaurosporineStaurosporine inhibits the reaction [GAST protein results in increased secretion of AREG protein]15474551
D019311StaurosporineStaurosporine inhibits the reaction [IL1B protein results in increased secretion of AREG protein]15474551
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of AREG mRNA16214533
C416927SU 6656SU 6656 results in decreased secretion of AREG protein15615697
C025462sulindac sulfidesulindac sulfide results in increased expression of AREG mRNA16184548
D016559TacrolimusTacrolimus results in increased expression of AREG mRNA21865292
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of AREG mRNA19059307
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of AREG mRNA]24758408
D013629TamoxifenTamoxifen results in increased expression of AREG mRNA16202921
C099410TAPI-2TAPI-2 inhibits the reaction [Particulate Matter results in increased secretion of AREG protein]22820758
D013739Testosterone[FSHB protein co-treated with Testosterone] results in increased expression of AREG mRNA18535249
D013739Testosterone[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of AREG mRNA18535249
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of AREG mRNA20189893
C004648testosterone enanthatetestosterone enanthate affects the expression of AREG mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of AREG mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AREG mRNA26854739
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of AREG mRNA]23625689
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of AREG protein]23625689
D013749TetrachlorodibenzodioxinAREG mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]23625689
D013749Tetrachlorodibenzodioxin[AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein]27117977
D013749Tetrachlorodibenzodioxin[AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]27117977
D013749Tetrachlorodibenzodioxinbatimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of AREG protein]27117977
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AREG mRNA22298810
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of AREG mRNA23625689
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AREG mRNA16704738|1806139
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased secretion of AREG protein23625689|2711797
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of AREG mRNA]16929009
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AREG mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AREG mRNA16929009|1977048
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AREG mRNA]23196670
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AREG mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AREG mRNA20558275|2172422
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of AREG mRNA28973375
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in increased expression of AREG mRNA26854739
D013755Tetradecanoylphorbol Acetatebisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of AREG mRNA]]22643241
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of AREG mRNA]22643241
D013755Tetradecanoylphorbol AcetateEGFR gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of AREG mRNA]20660715
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of AREG mRNA20660715
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AREG mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of AREG mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AREG mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AREG mRNA25788831
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AREG mRNA20133372
D014118Toxins, Biological"Toxins, Biological affects the expression of AREG mRNA"19682533
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of AREG mRNA"17951470
D014212TretinoinTretinoin results in increased expression of AREG mRNA16470170
D014212TretinoinTretinoin results in increased expression of AREG protein16470170
D014212TretinoinTretinoin results in increased secretion of AREG protein17763283
C012589trichostatin Atrichostatin A results in increased expression of AREG mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AREG mRNA"26179874
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [[AREG protein co-treated with Estradiol] results in increased phosphorylation of EGFR protein]21185374
C101044tyrphostin AG 1478tyrphostin AG 1478 results in decreased activity of AREG protein15706222
C113580U 0126U 0126 inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA]16888076
C113580U 0126U 0126 results in decreased secretion of AREG protein15615697
C113580U 0126U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]]23583632
C022884undecaneundecane results in increased expression of AREG protein17337753
D014635Valproic AcidValproic Acid promotes the reaction [Estradiol results in increased expression of AREG mRNA]19772891
D014635Valproic AcidValproic Acid results in increased expression of AREG mRNA24935251|2800136
D014638VanadatesVanadates results in increased expression of AREG mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AREG gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of AREG mRNA26682919
D024483Vitamin K 3Vitamin K 3 results in increased expression of AREG mRNA12414654
C009687wortmanninwortmannin results in decreased activity of AREG protein12589827
C104428YF 476[YF 476 co-treated with loxtidine] results in decreased expression of AREG mRNA15940630
C104428YF 476YF 476 results in decreased expression of AREG mRNA15940630
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of AREG mRNA18593933
D015032ZincZinc deficiency results in increased expression of AREG mRNA11717422|1911172
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of AREG mRNA]19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0005154epidermal growth factor receptor binding-IBA21873635  
GO:0005515protein binding-IPI19740107  
GO:0008083growth factor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007173epidermal growth factor receptor signaling pathway-IBA21873635  
GO:0007173epidermal growth factor receptor signaling pathway-IDA12743035  
GO:0007186G-protein coupled receptor signaling pathway-IDA12743035  
GO:0007267cell-cell signaling-TAS2466334  
GO:0008283cell proliferation-TAS2466334  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IMP12743035  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0014009glial cell proliferation-IEA-  
GO:0031175neuron projection development-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0042542response to hydrogen peroxide-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0045668negative regulation of osteoblast differentiation-IEA-  
GO:0048208COPII vesicle coating-TAS-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0051591response to cAMP-IEA-  
GO:0060598dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis-IEA-  
GO:0060744mammary gland branching involved in thelarche-IEA-  
GO:0060749mammary gland alveolus development-IEA-  
GO:0060750epithelial cell proliferation involved in mammary gland duct elongation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA12743035  22184114  
GO:0005634nucleus-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0009986cell surface-IDA12743035  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-TAS-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27709733EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium. (2017 Mar)Zuo WLStem Cells
29798216[Research progress of amphiregulin and its role in airway inflammatory disease]. (2018 Jan 5)Gao LLin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi