Gene: GALNT18

374378
GALNACT18|GALNT15|GALNTL4|GalNAc-T15|GalNAc-T18
polypeptide N-acetylgalactosaminyltransferase 18
protein-coding
11p15.4
Ensembl:ENSG00000110328 MIM:615136 Vega:OTTHUMG00000165707 UniprotKB:Q6P9A2
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.720e-1 (AD)  8.932e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12222290chr11:11455298 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANXA110.867
RIC8A0.854
TMEM1270.852
CSNK1D0.851
ACTN10.849
DBN10.846
PTDSS10.844
NEU10.837
SRC0.835
POMGNT20.834

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.596
OR4F29-0.573
CTNNA3-0.45
C5orf64-0.416
TRPV5-0.374
PDE11A-0.366
ZFP57-0.354
SLCO1A2-0.35
MOBP-0.344
VRK2-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GALNT18 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GALNT18 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GALNT18 mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT18 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GALNT18 mRNA29067470
D000447AldehydesAldehydes results in increased expression of GALNT18 mRNA25014914
C006632arsenic trioxidearsenic trioxide results in increased expression of GALNT18 mRNA20458559
C547126AZM551248AZM551248 results in decreased expression of GALNT18 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GALNT18 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GALNT18 mRNA20713471|2156981
C006780bisphenol Abisphenol A affects the expression of GALNT18 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GALNT18 gene28505145
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of GALNT18 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of GALNT18 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of GALNT18 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of GALNT18 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of GALNT18 mRNA20106945
D003976DiazinonDiazinon results in increased methylation of GALNT18 gene22964155
D004041Dietary FatsDietary Fats results in decreased expression of GALNT18 mRNA28031460
D002117CalcitriolCalcitriol results in decreased expression of GALNT18 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of GALNT18 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of GALNT18 mRNA21592394
D005557FormaldehydeFormaldehyde results in increased expression of GALNT18 mRNA18045764
D005839GentamicinsGentamicins results in decreased expression of GALNT18 mRNA22061828
D017313FenretinideFenretinide results in increased expression of GALNT18 mRNA28973697
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of GALNT18 mRNA20713471
D009151Mustard GasMustard Gas results in decreased expression of GALNT18 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GALNT18 mRNA"25620056
C025256nonylphenolnonylphenol results in decreased expression of GALNT18 mRNA22982499
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of GALNT18 mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of GALNT18 mRNA26516004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT18 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of GALNT18 mRNA26272509
C016030pantogabpantogab results in increased expression of GALNT18 mRNA17379144
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GALNT18 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GALNT18 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT18 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GALNT18 mRNA26272509
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of GALNT18 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of GALNT18 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GALNT18 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GALNT18 mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of GALNT18 mRNA23557971
C012589trichostatin Atrichostatin A results in increased expression of GALNT18 mRNA24935251
C057693troglitazonetroglitazone results in increased expression of GALNT18 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of GALNT18 mRNA22378314
D014520UrethaneUrethane results in increased expression of GALNT18 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT18 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GALNT18 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GALNT18 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GALNT18 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of GALNT18 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004653polypeptide N-acetylgalactosaminyltransferase activity-IDA22186971  
GO:0030246carbohydrate binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006493protein O-linked glycosylation-IDA22186971  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005575cellular_component-ND-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00512Mucin type O-Glycan biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal