Gene: KCNC2

3747
KV3.2
potassium voltage-gated channel subfamily C member 2
protein-coding
12q21.1
Ensembl:ENSG00000166006 MIM:176256 Vega:OTTHUMG00000169717 UniprotKB:Q96PR1
NC_000012.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.887e-1 (AD)  5.609e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17803126chr12:75183086 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCALD0.957
ELAVL20.952
GABRA10.95
SYT130.95
RGS40.947
KCNJ30.946
PRKCE0.943
TMEM1550.942
GABBR20.941
CDK140.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF5-0.603
REST-0.581
WWTR1-0.58
CSAG1-0.578
ACAP1-0.573
CNN2-0.568
CMTM3-0.563
RNF135-0.553
RBPMS-0.551
PTPN7-0.548

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06637DalfampridineSmall Molecule504-24-5ApprovedTarget
ID Drug Name Action PubMed
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"1-Methyl-3-isobutylxanthine promotes the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein]"7643197
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein"7643197
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"KT 5720 inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein]]"7643197
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein]]"7643197
D000082AcetaminophenAcetaminophen results in decreased expression of KCNC2 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of KCNC2 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNC2 mRNA16483693
C006780bisphenol Abisphenol A affects the expression of KCNC2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of KCNC2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of KCNC2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KCNC2 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of KCNC2 mRNA22079614
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of KCNC2 mRNA24763279
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of KCNC2 mRNA26033743
D003300CopperCopper deficiency results in increased expression of KCNC2 mRNA26033743
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of KCNC2 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of KCNC2 mRNA26033743
D000431EthanolEthanol results in decreased expression of KCNC2 mRNA21234782
C540355fenamidonefenamidone results in decreased expression of KCNC2 mRNA27029645
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of KCNC2 mRNA24763279
D0150561-Methyl-3-isobutylxanthine"1-Methyl-3-isobutylxanthine promotes the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein]"7643197
D0150561-Methyl-3-isobutylxanthine"KT 5720 inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein]]"7643197
D0150561-Methyl-3-isobutylxanthine"N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein]]"7643197
D007608Kainic AcidKainic Acid results in increased expression of KCNC2 protein7643197
D007649KetamineKetamine results in decreased expression of KCNC2 mRNA20080153
C057416KT 5720"KT 5720 inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein]]"7643197
C029310lardlard results in increased expression of KCNC2 mRNA26115784
D007854LeadLead affects the expression of KCNC2 mRNA28903495
D008278Magnesium SulfateMagnesium Sulfate results in decreased expression of KCNC2 mRNA18775767
D008278Magnesium SulfateMagnesium Sulfate results in decreased expression of KCNC2 protein18775767
D008731MethoxychlorMethoxychlor results in decreased expression of KCNC2 mRNA21782745
C053177N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide"N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in decreased activity of KCNC2 protein]]"7643197
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of KCNC2 mRNA12832660
D010126OzoneOzone results in increased expression of KCNC2 mRNA16330353
C006253pirinixic acidpirinixic acid results in increased expression of KCNC2 mRNA12832660
D011441PropylthiouracilPropylthiouracil results in decreased expression of KCNC2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of KCNC2 mRNA27029645
C017947sodium arsenitesodium arsenite affects the methylation of KCNC2 gene28589171
C049985staurosporine aglyconestaurosporine aglycone results in decreased expression of KCNC2 protein18775767
D019789TetraethylammoniumTetraethylammonium results in decreased activity of KCNC2 protein10482766
D013779TetrodotoxinTetrodotoxin results in decreased expression of KCNC2 mRNA18775767
D013779TetrodotoxinTetrodotoxin results in decreased expression of KCNC2 protein18775767
D014050TolueneToluene results in increased expression of KCNC2 mRNA22967744
C113580U 0126U 0126 results in decreased expression of KCNC2 protein18775767
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KCNC2 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of KCNC2 mRNA25423262
C029297vinylidene chloridevinylidene chloride results in decreased expression of KCNC2 mRNA26682919
D055549Volatile Organic CompoundsVolatile Organic Compounds results in decreased expression of KCNC2 mRNA21234782

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005249voltage-gated potassium channel activity-IBA21873635  
GO:0005249voltage-gated potassium channel activity-ISS-  
GO:0005251delayed rectifier potassium channel activity-IBA21873635  
GO:0005251delayed rectifier potassium channel activity-ISS-  
GO:0044325ion channel binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009642response to light intensity-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0014075response to amine-IEA-  
GO:0021759globus pallidus development-IEA-  
GO:0032026response to magnesium ion-IEA-  
GO:0038060nitric oxide-cGMP-mediated signaling pathway-ISS-  
GO:0045471response to ethanol-IEA-  
GO:0050796regulation of insulin secretion-TAS-  
GO:0051260protein homooligomerization-ISS-  
GO:0051291protein heterooligomerization-ISS-  
GO:0071242cellular response to ammonium ion-IEA-  
GO:0071732cellular response to nitric oxide-ISS-  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-ISS-  
GO:0097237cellular response to toxic substance-IEA-  
GO:1903818positive regulation of voltage-gated potassium channel activity-IEA-  
GO:1990089response to nerve growth factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0008076voltage-gated potassium channel complex-IBA21873635  
GO:0008076voltage-gated potassium channel complex-ISS-  
GO:0016020membrane-ISS-  
GO:0016021integral component of membrane-IBA21873635  
GO:0016323basolateral plasma membrane-ISS-  
GO:0016324apical plasma membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0030424axon-IBA21873635  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0030673axolemma-IEA-  
GO:0031982vesicle-IEA-  
GO:0032590dendrite membrane-IBA21873635  
GO:0032809neuronal cell body membrane-IBA21873635  
GO:0032809neuronal cell body membrane-ISS-  
GO:0042734presynaptic membrane-ISS-  
GO:0043025neuronal cell body-IBA21873635  
GO:0043195terminal bouton-IEA-  
GO:0043204perikaryon-ISS-  
GO:0045202synapse-ISS-  
GO:0045211postsynaptic membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296072Voltage gated Potassium channelsTAS
R-HSA-1430728MetabolismTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionTAS
R-HSA-422356Regulation of insulin secretionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal