Gene: ZNF699

374879
hang
zinc finger protein 699
protein-coding
19p13.2
Ensembl:ENSG00000196110 MIM:609571 Vega:OTTHUMG00000179941 UniprotKB:Q32M78
NC_000019.10
PubMed
0   ANCO-SNPs
OD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.380e-1 (AD)  1.071e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SHPRH0.797
PHC30.787
USP370.773
NFAT50.773
ATF7IP0.762
MTX30.75
ALG110.749
HCFC20.748
SLC12A60.746
LNPEP0.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NANOS3-0.33
NPFF-0.327
FAM229A-0.307
S100A1-0.302
VCX3A-0.294
TMEM86B-0.282
SEPT1-0.27
MUC12-0.26
PPP1R14B-0.26
NANOGNB-0.26

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of ZNF699 mRNA24834073
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF699 mRNA27392435
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF699 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ZNF699 mRNA27392435
C029938nickel sulfatenickel sulfate results in increased expression of ZNF699 mRNA22714537
D010936Plant ExtractsPlant Extracts results in increased expression of ZNF699 mRNA23557933
D014638VanadatesVanadates results in decreased expression of ZNF699 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16940975Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample. (2006 Nov)Riley BPMol Psychiatry
26368818Phenotypic heterogeneity in study populations may significantly confound the results of genetic association studies on alcohol dependence. (2015 Dec)Ali MAPsychiatr Genet