Gene info: ID 375

Gene: ARF1

GENE ID: 375

Synonyms: -

Description: ADP ribosylation factor 1

Gene type: protein-coding

Location: 1q42.13

dbXrefs: Ensembl:ENSG00000143761 MIM:103180 Vega:OTTHUMG00000037595 UniprotKB:P84077

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.415e-2 (AD) 7.117e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg18882687	chr1:228275828	ARF1		8.600e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MLF2	0.976
ARPC4	0.965
POLDIP2	0.962
WBP2	0.962
ALDOA	0.961
VPS4A	0.96
GDI1	0.96
BCL7B	0.959
CFL1	0.958
CAPNS1	0.957

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.854
OR4F29	-0.818
MTRNR2L6	-0.26
MTRNR2L9	-0.251
MTRNR2L10	-0.239
KLRB1	-0.236
KCNJ15	-0.224
C9orf153	-0.224
TFPI2	-0.218
CXCR2	-0.217

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02774	1,3-Propandiol	Small Molecule		Experimental	Target
DB04121	Guanosine-3'-Monophosphate-5'-Diphosphate	Small Molecule		Experimental	Target
DB04137	Guanosine-5'-Triphosphate	Small Molecule	86-01-1	Experimental	Target
DB04315	Guanosine-5'-Diphosphate	Small Molecule	146-91-8	Experimental	Target
DB07348	Brefeldin A	Small Molecule	20350-15-6	Experimental	Target
DB08231	Myristic acid	Small Molecule	544-63-8	Experimental	Target
DB09462	Glycerin	Small Molecule	56-81-5	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ARF1 mRNA"	25614096
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of ARF1 mRNA"	20206263
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ARF1 mRNA	12958071
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARF1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARF1 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ARF1 mRNA	19770486
D001151	Arsenic	Arsenic affects the methylation of ARF1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ARF1 mRNA	20458559
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of ARF1 mRNA	21632023
C095105	bexarotene	bexarotene results in increased expression of ARF1 mRNA	16648578
C006780	bisphenol A	bisphenol A affects the expression of ARF1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of ARF1 mRNA	28196854
C006780	bisphenol A	bisphenol A results in increased expression of ARF1 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARF1 mRNA	28628672
D002104	Cadmium	Cadmium results in increased expression of ARF1 mRNA	23369406
D002104	Cadmium	ARF1 protein results in increased susceptibility to [Cadmium binds to MT1A protein]	21421027
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ARF1 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA]"	20230807
D002330	Carmustine	ARF1 mRNA affects the susceptibility to Carmustine	16365179
C099555	CD 437	CD 437 results in decreased expression of ARF1 mRNA	12958071
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of ARF1 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of ARF1 mRNA	23650126
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARF1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of ARF1 mRNA	26272509
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARF1 gene	20938992
D002994	Clofibrate	Clofibrate results in decreased expression of ARF1 mRNA	17585979
D003300	Copper	ARF1 mutant form inhibits the reaction [ATP7A gene mutant form results in decreased export of and results in increased abundance of Copper]	21034850
D003300	Copper	ARF1 mutant form results in decreased uptake of and results in decreased abundance of Copper	21034850
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of ARF1 mRNA	20971185
D003300	Copper	Copper results in increased expression of ARF1 mRNA	18522721
D016572	Cyclosporine	Cyclosporine results in increased expression of ARF1 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of ARF1 mRNA	19770486
D003634	DDT	DDT results in decreased expression of ARF1 mRNA	19797855
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARF1 mRNA	28628672
D002945	Cisplatin	Cisplatin results in decreased expression of ARF1 mRNA	27594783
D004391	Dust	Dust results in decreased expression of ARF1 mRNA	17805423
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ARF1 protein	23301498
D000069347	Erlotinib Hydrochloride	ARF1 mRNA results in decreased susceptibility to Erlotinib Hydrochloride	23125191
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ARF1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ARF1 mRNA	17942748
D005472	Fluorouracil	ARF1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]	18927307
D005485	Flutamide	Flutamide results in increased expression of ARF1 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARF1 gene	20938992
D009240	N-Formylmethionine Leucyl-Phenylalanine	N-Formylmethionine Leucyl-Phenylalanine affects the localization of ARF1 protein	10931844
C056507	gemcitabine	gemcitabine results in decreased expression of ARF1 mRNA	17039268
D019833	Genistein	Genistein results in decreased expression of ARF1 mRNA	16705744
D006153	Guanosine Diphosphate	LM11 compound binds to [ARF1 protein binds to Guanosine Diphosphate]	17563369\|1883486
D006220	Haloperidol	Haloperidol results in decreased expression of ARF1 mRNA	15860345
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of ARF1 mRNA	17183730
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARF1 protein	18951874
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARF1 mRNA	28628672
C051890	irinotecan	ARF1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]	18927307
C051890	irinotecan	irinotecan analog results in decreased expression of ARF1 mRNA	18927307
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARF1 mRNA	28628672
C410337	K 7174	K 7174 results in decreased expression of ARF1 mRNA	24086573
D007657	Ketone Bodies	Ketone Bodies results in increased expression of ARF1 mRNA	16807920
C521938	LM11 compound	LM11 compound results in decreased activity of ARF1 protein	27517156
C521938	LM11 compound	LM11 compound binds to [ARF1 protein binds to Guanosine Diphosphate]	17563369\|1883486
C521938	LM11 compound	LM11 compound results in decreased activity of [CYTH2 protein results in increased activity of ARF1 protein]	17563369
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARF1 gene	20938992
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ARF1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA]"	20230807
C051752	nefazodone	nefazodone results in increased expression of ARF1 mRNA	24136188
D009534	Niclosamide	Niclosamide results in increased expression of ARF1 mRNA	26452273
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF1 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA]"	20230807
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of ARF1 mRNA	20971185
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of ARF1 mRNA	18636392
D010269	Paraquat	Paraquat affects the expression of ARF1 mRNA	15206577
D010795	Phthalic Acids	Phthalic Acids results in increased expression of ARF1 mRNA	21061450
D010938	Plant Oils	Plant Oils results in increased expression of ARF1 mRNA	23370395
D011748	Pyrogallol	Pyrogallol results in increased expression of ARF1 mRNA	20362636
C059514	resveratrol	resveratrol results in increased expression of ARF1 protein	25505154
C016104	sodium bichromate	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of ARF1 mRNA	21632023
D013629	Tamoxifen	Tamoxifen affects the expression of ARF1 mRNA	17555576
C047246	temozolomide	ARF1 mRNA affects the susceptibility to temozolomide	16365179
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate affects the localization of ARF1 protein	10931844
D013806	Theophylline	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARF1 protein	18951874
D013893	Thiram	Thiram results in decreased expression of ARF1 mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of ARF1 mRNA	21934132
C012589	trichostatin A	trichostatin A results in increased expression of ARF1 mRNA	24935251
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of ARF1 mRNA	21346803
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of ARF1 mRNA	17183730
D014635	Valproic Acid	Valproic Acid results in increased expression of ARF1 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid affects the expression of ARF1 mRNA	17292431\|1796380
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of ARF1 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of ARF1 mRNA	23034163
D014750	Vincristine	Vincristine results in increased expression of ARF1 mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22681889
GO:0003924	GTPase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	10198630 14654833 17563369 17956946 19644450
GO:0005525	GTP binding	-	IBA	21873635
GO:0005525	GTP binding	-	IEA	-
GO:0019904	protein domain specific binding	-	IPI	12668765
GO:0046982	protein heterodimerization activity	-	IMP	12668765

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002090	regulation of receptor internalization	-	ISS	-
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	-
GO:0006878	cellular copper ion homeostasis	-	IMP	21034850
GO:0006886	intracellular protein transport	-	IBA	21873635
GO:0006893	Golgi to plasma membrane transport	-	IBA	21873635
GO:0015031	protein transport	-	IEA	-
GO:0016192	vesicle-mediated transport	-	IBA	21873635
GO:0016192	vesicle-mediated transport	-	IEA	-
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	-
GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	-	ISS	-
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	-
GO:0050690	regulation of defense response to virus by virus	-	TAS	-
GO:0060292	long term synaptic depression	-	ISS	-
GO:0097061	dendritic spine organization	-	ISS	-
GO:0098586	cellular response to virus	-	IMP	28389568

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005794	Golgi apparatus	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	8529647
GO:0005925	focal adhesion	-	HDA	21423176
GO:0014069	postsynaptic density	-	IEA	-
GO:0031252	cell leading edge	-	IDA	22573891
GO:0032991	protein-containing complex	-	IMP	12668765
GO:0043005	neuron projection	-	IEA	-
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19199708 20458337 23533145

KEGG ID	KEGG Term
hsa05110	Vibrio cholerae infection

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1483255	PI Metabolism	TAS
R-HSA-1483257	Phospholipid metabolism	TAS
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1643685	Disease	TAS
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	TAS
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	TAS
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	TAS
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	TAS
R-HSA-167590	Nef Mediated CD4 Down-regulation	TAS
R-HSA-168256	Immune System	TAS
R-HSA-199977	ER to Golgi Anterograde Transport	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-199992	trans-Golgi Network Vesicle Budding	TAS
R-HSA-2132295	MHC class II antigen presentation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-421837	Clathrin derived vesicle budding	TAS
R-HSA-432720	Lysosome Vesicle Biogenesis	TAS
R-HSA-432722	Golgi Associated Vesicle Biogenesis	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-447115	Interleukin-12 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6807878	COPI-mediated anterograde transport	TAS
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811438	Intra-Golgi traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-8856688	Golgi-to-ER retrograde transport	TAS
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	TAS
R-HSA-9020591	Interleukin-12 signaling	TAS
R-HSA-948021	Transport to the Golgi and subsequent modification	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18671841	PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells. (2008 Jul 31)	Kriegova E	BMC Mol Biol