Gene: PEAR1

375033
JEDI|MEGF12
platelet endothelial aggregation receptor 1
protein-coding
1q23.1
Ensembl:ENSG00000187800 MIM:610278 Vega:OTTHUMG00000041293 UniprotKB:Q5VY43
NC_000001.11
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.754e-1 (AD)  9.311e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DOCK60.861
FOXC10.834
TINAGL10.83
ESAM0.828
LEF10.828
PDGFRB0.819
MECOM0.816
ITGA10.815
LAMB20.813
MMRN20.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.539
CRH-0.488
SLC7A4-0.481
FSTL5-0.477
MARCH4-0.476
HAS1-0.472
PTPRR-0.465
KCNB2-0.463
PPEF1-0.463
MYADML2-0.459

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PEAR1 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEAR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEAR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEAR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEAR1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PEAR1 mRNA21641981
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PEAR1 mRNA24449571
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PEAR1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PEAR1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PEAR1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of PEAR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PEAR1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PEAR1 mRNA26472689
D003471CuprizoneCuprizone results in increased expression of PEAR1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of PEAR1 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of PEAR1 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PEAR1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of PEAR1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PEAR1 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of PEAR1 mRNA25016146
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of PEAR1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of PEAR1 mRNA28628672
D008774MethylphenidateMethylphenidate results in increased expression of PEAR1 mRNA22470460
D009532NickelNickel results in decreased expression of PEAR1 mRNA24768652|2558310
C025589ochratoxin Aochratoxin A results in increased acetylation of PEAR1 promoter29098329
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEAR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PEAR1 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PEAR1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PEAR1 mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of PEAR1 mRNA26079696
D011794QuercetinQuercetin results in increased expression of PEAR1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PEAR1 mRNA25895662
D012834SilverSilver results in increased expression of PEAR1 mRNA27131904
D014212TretinoinTretinoin results in increased expression of PEAR1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of PEAR1 mRNA24935251
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PEAR1 mRNA29024780
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEAR1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PEAR1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of PEAR1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PEAR1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0043654recognition of apoptotic cell-IEA-  
GO:0045746negative regulation of Notch signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001891phagocytic cup-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28449647PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population. (2017 Apr 27)Yang WYBMC Med Genet
25541647PEAR1 is not a human hypertension-susceptibility gene. (2015 Feb)Olivi LBlood Press