Gene: MIA3

375056
ARNT|D320|TANGO|TANGO1|UNQ6077
MIA SH3 domain ER export factor 3
protein-coding
1q41
Ensembl:ENSG00000154305 MIM:613455 Vega:OTTHUMG00000037543 UniprotKB:Q5JRA6
NC_000001.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.249e-1 (AD)  5.991e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06186137chr1:222792587MIA3Gene body1.162e-4Alcohol use disorders26763658
cg01770296chr1:222792554MIA3Gene body3.167e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RALGAPB0.955
KAT70.951
FOXJ30.948
CAND10.947
KPNA60.946
UBP10.944
SUDS30.943
AP1G10.943
CD470.942
KPNA10.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.507
MYL3-0.355
COPZ2-0.355
CSAG1-0.35
HEY2-0.338
ASB4-0.333
MYOM1-0.332
CTNNA3-0.321
S100A1-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MIA3 mRNA]"19467301
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MIA3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MIA3 mRNA24449571
D001151ArsenicArsenic affects the methylation of MIA3 gene25304211
C547126AZM551248AZM551248 results in increased expression of MIA3 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of MIA3 mRNA26377693
C006780bisphenol Abisphenol A affects the expression of MIA3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MIA3 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MIA3 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of MIA3 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of MIA3 mRNA26794494
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MIA3 mRNA15003993
C018475butyraldehydebutyraldehyde results in decreased expression of MIA3 mRNA26079696
D002994ClofibrateClofibrate results in decreased expression of MIA3 mRNA23811191
D016572CyclosporineCyclosporine results in increased expression of MIA3 mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MIA3 mRNA]27941970
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MIA3 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of MIA3 mRNA19467301
D004237DiuronDiuron results in decreased expression of MIA3 mRNA25152437
D004726EndosulfanEndosulfan results in increased expression of MIA3 mRNA26615145
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MIA3 protein23301498
D005485FlutamideFlutamide results in decreased expression of MIA3 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of MIA3 mRNA24136188
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MIA3 mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MIA3 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MIA3 mRNA"25620056
C012655nimesulidenimesulide results in increased expression of MIA3 mRNA24136188
D010634PhenobarbitalPhenobarbital results in decreased expression of MIA3 mRNA23091169
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MIA3 mRNA"21148743
C017947sodium arsenitesodium arsenite results in decreased expression of MIA3 mRNA28595984
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MIA3 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MIA3 mRNA21570461
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of MIA3 mRNA28973375
D013849ThimerosalThimerosal results in increased expression of MIA3 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MIA3 mRNA28065790
C066340tolcaponetolcapone results in decreased expression of MIA3 mRNA24136188
C057693troglitazonetroglitazone results in decreased expression of MIA3 mRNA28973697
D014520UrethaneUrethane results in increased expression of MIA3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MIA3 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of MIA3 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17726152  19269366  21525241  25202031  27138255  27170179  
27551091  
GO:0042954lipoprotein transporter activity-IBA21873635  
GO:0042954lipoprotein transporter activity-IMP27138255  
GO ID GO Term Qualifier Evidence PubMed
GO:0002687positive regulation of leukocyte migration-IDA17726152  
GO:0006887exocytosis-IMP19269366  
GO:0006888ER to Golgi vesicle-mediated transport-IBA21873635  
GO:0006888ER to Golgi vesicle-mediated transport-IMP27138255  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007162negative regulation of cell adhesion-IDA17726152  
GO:0009306protein secretion-IBA21873635  
GO:0015031protein transport-IMP19269366  
GO:0030336negative regulation of cell migration-IDA17044017  
GO:0035459cargo loading into vesicle-IBA21873635  
GO:0042060wound healing-IDA17044017  
GO:0042953lipoprotein transport-IMP27138255  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0090110cargo loading into COPII-coated vesicle-IMP27138255  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005789endoplasmic reticulum membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IDA19269366  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IDA19269366  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070971endoplasmic reticulum exit site-IBA21873635  
GO:0070971endoplasmic reticulum exit site-IDA21525241  25202031  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21264445Extended evidence for association between the melanoma inhibitory activity 3 gene and myocardial infarction. (2011 Apr)Koch WThromb Haemost
28737528Genetic variants of increased waist circumference in psychosis. (2017 Dec)Hukic DSPsychiatr Genet
28167353Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar)Shahid SUAtherosclerosis