Gene: KCNE1

3753
ISK|JLNS|JLNS2|LQT2/5|LQT5|MinK
potassium voltage-gated channel subfamily E regulatory subunit 1
protein-coding
21q22.12
Ensembl:ENSG00000180509 MIM:176261 Vega:OTTHUMG00000086236 UniprotKB:P15382
NG_009091.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.080e-1 (AD)  7.739e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LINC008540.619
TGFBI0.617
PCDH180.6
SVIL0.592
ITGB30.591
NABP10.59
STK100.588
CCDC360.586
CD930.584
TNFSF150.584

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.335
CHST8-0.317
ASPDH-0.311
NT5M-0.31
FBLL1-0.304
BCL11A-0.302
RS1-0.3
FEZF2-0.299
C1orf53-0.292
HAGHL-0.289

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00808IndapamideSmall Molecule26807-65-8ApprovedTarget
DB04957AzimilideSmall Molecule149908-53-2InvestigationalTarget
ID Drug Name Action PubMed
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol results in decreased activity of KCNE1 protein1655403
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of KCNE1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNE1 mRNA"27188386
C1034746-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane"6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]"16909339
D020106AcrylamideKCNE1 protein promotes the reaction [Acrylamide analog results in decreased activity of KCNQ1 protein]16904708
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KCNE1 gene27153756
D000638AmiodaroneAmiodarone results in decreased activity of KCNE1 protein18329740
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNE1 mRNA16483693
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of KCNE1 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of KCNE1 mRNA23912714
C006632arsenic trioxidearsenic trioxide affects the activity of [KCNQ1 protein co-treated with KCNE1 protein]14691044
D001464BariumBarium results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]16909339
C024986barium chloridebarium chloride results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]16909339
C006780bisphenol Abisphenol A results in increased expression of KCNE1 mRNA25181051
D002045BupivacaineBupivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]16931984
D002045BupivacaineKCNE1 protein inhibits the reaction [KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine]16931984
D002118CalciumCalcium results in increased activity of KCNE1 protein1655403
D002118CalciumW 7 inhibits the reaction [Calcium results in increased activity of KCNE1 protein]1655403
C022799clofiliumclofilium results in decreased activity of KCNE1 protein1655403
D003300CopperCopper deficiency results in increased expression of KCNE1 mRNA26033743
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KCNE1 mRNA21266533
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of KCNE1 mRNA20920545
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of KCNE1 mRNA12655031
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of KCNE1 gene16724327
D004397FonofosFonofos results in increased methylation of KCNE1 promoter22847954
D019833GenisteinGenistein results in decreased expression of KCNE1 mRNA21810550
C442759ginsenoside Rb1ginsenoside Rb1 results in increased expression of KCNE124615935
C049864ginsenoside Reginsenoside Re results in increased expression of KCNE124615935
C420023HMR 1556HMR 1556 results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]16909339
D007545IsoproterenolIsoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]16909339
D007545IsoproterenolN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]]16909339
D007545IsoproterenolIsoproterenol results in decreased expression of KCNE1 mRNA20003209
C113498L 364373L 364373 results in increased activity of [KCNQ1 protein binds to KCNE1 protein]16945016
D008619MepivacaineMepivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]16931984
D008627Mercuric ChlorideMercuric Chloride results in increased expression of KCNE1 mRNA16507785
D008694MethamphetamineMethamphetamine results in increased expression of KCNE1 mRNA15644446
D009151Mustard GasMustard Gas results in increased expression of KCNE1 mRNA15674843
C476437N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamideKCNE1 protein promotes the reaction [N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide results in decreased activity of KCNQ1 protein]16904708
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]]16909339
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of KCNE1 mRNA17725831
D010269ParaquatParaquat results in increased expression of KCNE1 mRNA18198484
D010278ParathionParathion results in increased methylation of KCNE1 promoter22847954
D010424PentobarbitalPentobarbital results in decreased activity of KCNE1 protein11862331
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KCNE1 mRNA27153767
D011188Potassium[KCNQ1 protein binds to KCNE1 protein] which affects the transport of Potassium16909339
D011192Potassium DichromatePotassium Dichromate results in increased expression of KCNE1 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of KCNE1 mRNA20726854
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of KCNE1 mRNA15576828
C037663ropivacaineropivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]16931984
C017947sodium arsenitesodium arsenite results in decreased expression of KCNE1 mRNA21776218
C012568terbufosterbufos results in increased methylation of KCNE1 promoter22847954
D016593TerfenadineKCNE1 protein inhibits the reaction [KCNQ1 protein mutant form results in increased susceptibility to Terfenadine]16931984
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased activity of KCNE1 protein1655403
D014212TretinoinTretinoin results in increased expression of KCNE1 mRNA20488242
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of KCNE1 mRNA]27469509
C012589trichostatin Atrichostatin A results in increased expression of KCNE1 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNE1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of KCNE1 mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KCNE1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of KCNE1 mRNA26682919
C017967W 7W 7 inhibits the reaction [Calcium results in increased activity of KCNE1 protein]1655403

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005249voltage-gated potassium channel activityCONTRIBUTES_TOIBA21873635  
GO:0005249voltage-gated potassium channel activitycontributes_toIDA17289006  
GO:0005251delayed rectifier potassium channel activity-IDA24269949  
GO:0005251delayed rectifier potassium channel activitycontributes_toIDA8900283  9354802  10400998  11299204  12522251  19646991  
GO:0005515protein binding-IPI11101505  11697903  19521339  20196769  20533308  25037568  
GO:0015459potassium channel regulator activity-IBA21873635  
GO:0015459potassium channel regulator activity-IDA8900283  10400998  11220365  12522251  19219384  
GO:0031433telethonin binding-IPI11697903  
GO:0086008voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationcontributes_toIDA10400998  
GO:1902282voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationcontributes_toIMP9354802  
GO ID GO Term Qualifier Evidence PubMed
GO:0006487protein N-linked glycosylation-IDA21669976  
GO:0006493protein O-linked glycosylation-IDA21669976  
GO:0007605sensory perception of sound-TAS9020846  
GO:0060306regulation of membrane repolarization-IBA21873635  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-IMP9354802  
GO:0071320cellular response to cAMP-IDA11299204  
GO:0071435potassium ion export-IDA8900283  10400998  17289006  
GO:0071805potassium ion transmembrane transport-IDA8900283  9354802  11299204  
GO:0086002cardiac muscle cell action potential involved in contraction-IMP10400998  
GO:0086005ventricular cardiac muscle cell action potential-IMP9354802  
GO:0086009membrane repolarization-IDA8900283  
GO:0086011membrane repolarization during action potential-IBA21873635  
GO:0086011membrane repolarization during action potential-IDA8900283  11299204  19646991  
GO:0086013membrane repolarization during cardiac muscle cell action potential-IDA8900283  
GO:0086013membrane repolarization during cardiac muscle cell action potential-IMP10400998  
GO:0086091regulation of heart rate by cardiac conduction-IMP10400998  
GO:0090315negative regulation of protein targeting to membrane-ISS-  
GO:0098915membrane repolarization during ventricular cardiac muscle cell action potential-IMP9354802  
GO:1901379regulation of potassium ion transmembrane transport-IBA21873635  
GO:1901379regulation of potassium ion transmembrane transport-IDA10400998  
GO:1901381positive regulation of potassium ion transmembrane transport-IDA8900283  
GO:1902259regulation of delayed rectifier potassium channel activity-IDA10400998  
GO:1902260negative regulation of delayed rectifier potassium channel activity-IDA19219384  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-HDA16780588  
GO:0005886plasma membrane-HDA16780588  
GO:0005886plasma membrane-IDA19219384  
GO:0005886plasma membrane-TAS-  
GO:0008076voltage-gated potassium channel complex-IBA21873635  
GO:0008076voltage-gated potassium channel complex-IC8900283  
GO:0008076voltage-gated potassium channel complex-IDA17289006  19646991  
GO:0008076voltage-gated potassium channel complexcolocalizes_withIDA19219384  
GO:0009986cell surface-IDA10400998  
GO:0016324apical plasma membrane-ISS-  
GO:0030018Z disc-ISS11697903  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-5576890Phase 3 - rapid repolarisationTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576893Phase 2 - plateau phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18956684[Study on the correlation between CETP TaqIB, KCNE1 S38G and eNOS T-786C gene polymorphisms for predisposition and non-valvular atrial fibrillation]. (2008 May)Xu LXZhonghua Liu Xing Bing Xue Za Zhi
16266404Possible association of the human KCNE1 (minK) gene and QT interval in healthy subjects: evidence from association and linkage analyses in Israeli families. (2005 Nov)Friedlander YAnn Hum Genet