Gene: KCNF1

3754
IK8|KCNF|KV5.1|kH1
potassium voltage-gated channel modifier subfamily F member 1
protein-coding
2p25.1
Ensembl:ENSG00000162975 MIM:603787 Vega:OTTHUMG00000119054 UniprotKB:Q9H3M0
NG_050750.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.653e-3 (AD)  9.727e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNGR30.929
CACNB10.926
SYT50.924
SYT120.924
STX1A0.923
PTPRN0.92
SEZ6L20.92
ATP6V0D10.916
LINGO10.914
DIRAS10.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARD3B-0.543
REST-0.537
OR4F5-0.528
YES1-0.52
WWTR1-0.519
RBPMS-0.514
CARD8-0.503
CDC14A-0.502
PRKD3-0.497
CLEC2B-0.497

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of KCNF1 mRNA"18648102
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KCNF1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to KCNF1 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of KCNF1 mRNA"20382639
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of KCNF1 mRNA20404318
D004958EstradiolEstradiol results in increased expression of KCNF1 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of KCNF1 mRNA19371625
C006780bisphenol Abisphenol A results in decreased expression of KCNF1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KCNF1 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNF1 gene20938992
D060729Coal AshCoal Ash results in decreased expression of KCNF1 mRNA19000753
D003300CopperCopper deficiency results in increased expression of KCNF1 mRNA26033743
D003907DexamethasoneDexamethasone results in increased expression of KCNF1 mRNA22733784
D019422Dietary SucroseDietary Sucrose results in increased expression of KCNF1 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of KCNF1 mRNA19371625
D015025ZearalenoneZearalenone results in increased expression of KCNF1 mRNA19371625
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNF1 gene20938992
D019833GenisteinGenistein results in increased expression of KCNF1 mRNA19371625|2301914
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KCNF1 mRNA25307878
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNF1 gene20938992
C046012pentanalpentanal results in increased expression of KCNF1 mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of KCNF1 mRNA23557933
C541923sandostatinLARsandostatinLAR results in increased expression of KCNF1 mRNA17210224
D017974Uranium CompoundsUranium Compounds results in increased expression of KCNF1 mRNA19654044
D014635Valproic AcidValproic Acid results in increased methylation of KCNF1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of KCNF1 mRNA17292431|1796380
C025643vinclozolinvinclozolin results in decreased expression of KCNF1 mRNA22615374

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005249voltage-gated potassium channel activity-IBA21873635  
GO:0005267potassium channel activity-TAS9434767  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-TAS9434767  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0008076voltage-gated potassium channel complex-IBA21873635  
GO:0008076voltage-gated potassium channel complex-IEA-  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296072Voltage gated Potassium channelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27490364High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model. (2016 Aug)Lo CLPLoS Genet