Gene: MAST4

375449
-
microtubule associated serine/threonine kinase family member 4
protein-coding
5q12.3
Ensembl:ENSG00000069020 Vega:OTTHUMG00000152471 UniprotKB:O15021
NG_034036.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.019e-1 (AD)  1.274e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6866391chr5:67028247 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAK10.901
LONP20.898
NR3C20.896
SYNE10.893
OSBPL60.89
CLASP10.889
ARHGAP320.887
WIPF20.882
SORL10.881
RPRD20.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.509
OR4F29-0.455
CTNNA3-0.443
SH2D1A-0.432
GNG8-0.408
SGMS2-0.393
ANXA13-0.38
TGFB3-0.38
TNFRSF13B-0.375
C5orf64-0.364

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MAST4 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MAST4 mRNA"27291303
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MAST4 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MAST4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAST4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MAST4 mRNA21641981
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MAST4 mRNA24449571
D001151ArsenicArsenic affects the methylation of MAST4 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of MAST4 mRNA"25351596
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MAST4 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MAST4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MAST4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MAST4 mRNA12160620
D019327Copper SulfateCopper Sulfate results in increased expression of MAST4 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MAST4 mRNA"19167446
D016572CyclosporineCyclosporine results in decreased expression of MAST4 mRNA25562108|2798913
D003907DexamethasoneDexamethasone results in increased expression of MAST4 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MAST4 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MAST4 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MAST4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MAST4 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of MAST4 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of MAST4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of MAST4 mRNA21592394
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MAST4 mRNA28329830
D005472FluorouracilFluorouracil results in increased expression of MAST4 mRNA16510598
D005557FormaldehydeFormaldehyde results in decreased expression of MAST4 mRNA20655997
D005839GentamicinsGentamicins results in decreased expression of MAST4 mRNA22061828
D017313FenretinideFenretinide results in increased expression of MAST4 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MAST4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MAST4 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MAST4 mRNA27392435
D007854LeadLead affects the expression of MAST4 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MAST4 mRNA"24972896
C042720mercuric bromidemercuric bromide results in increased expression of MAST4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MAST4 mRNA29191790
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MAST4 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAST4 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MAST4 mRNA20813756
D012715Sesame OilSesame Oil results in increased expression of MAST4 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MAST4 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of MAST4 mRNA25351596
D012906SmokeSmoke results in decreased expression of MAST4 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of MAST4 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of MAST4 mRNA27862939
D053260SootSoot results in decreased expression of MAST4 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of MAST4 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of MAST4 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAST4 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MAST4 mRNA28065790
D014212TretinoinTretinoin results in increased expression of MAST4 mRNA21934132|2383079
C011559tributyltintributyltin results in decreased expression of MAST4 mRNA27614199
D014415TunicamycinTunicamycin results in increased expression of MAST4 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAST4 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of MAST4 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of MAST4 mRNA23179753|2438349
D014640VancomycinVancomycin results in decreased expression of MAST4 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of MAST4 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of MAST4 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of MAST4 mRNA19244175
C088658zoledronic acidzoledronic acid results in increased expression of MAST4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0035556intracellular signal transduction-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal