Gene: SIMC1

375484
C5orf25|OOMA1|PLEIAD
SUMO interacting motifs containing 1
protein-coding
5q35.2
Ensembl:ENSG00000170085 Vega:OTTHUMG00000130663 UniprotKB:Q8NDZ2
NC_000005.10
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.162e-1 (AD)  6.859e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11134973chr5:176343419 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11134972chr5:176343418 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs13169783chr5:176337365 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL180.924
KCND30.923
ACVR1B0.922
RBBP50.919
PHLPP20.917
KAT70.916
HERC30.913
ANKRD420.913
ACTN10.913
OCRL0.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.471
HEY2-0.424
OR4F29-0.417
COPZ2-0.417
FZD10-0.407
CTNNA3-0.402
RAI14-0.395
ASB4-0.395
MYL3-0.388
SH2D1A-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of SIMC1 mRNA22230336
D001151ArsenicArsenic affects the methylation of SIMC1 gene25304211
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SIMC1 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of SIMC1 mRNA26063408
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SIMC1 mRNA20971185
C000944dicrotophosdicrotophos results in increased expression of SIMC1 mRNA28302478
D008627Mercuric ChlorideMercuric Chloride results in increased expression of SIMC1 mRNA16507785
C029938nickel sulfatenickel sulfate results in increased expression of SIMC1 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SIMC1 mRNA20971185
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SIMC1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SIMC1 mRNA28903501
C024746tobacco tartobacco tar results in increased expression of SIMC1 mRNA19559774
C012589trichostatin Atrichostatin A results in increased expression of SIMC1 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of SIMC1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of SIMC1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SIMC1 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased methylation of SIMC1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SIMC1 mRNA24935251
D014638VanadatesVanadates results in decreased expression of SIMC1 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0032184SUMO polymer binding-IBA21873635  
GO:0032184SUMO polymer binding-IDA23086935  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal