Gene: VWC2

375567
PSST739|UNQ739
von Willebrand factor C domain containing 2
protein-coding
7p12.2
Ensembl:ENSG00000188730 MIM:611108 Vega:OTTHUMG00000129265 UniprotKB:Q2TAL6
NC_000007.14
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.084e-1 (AD)  4.452e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4916992chr7:49793276 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF385D0.931
GAD10.925
GAD20.924
NRIP30.905
BTBD110.898
SLC32A10.897
ZNF804A0.897
LHX60.895
GJD20.889
MYO5B0.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDA-0.61
TGIF1-0.61
AGTRAP-0.607
ROM1-0.603
ATOH8-0.602
TIMP1-0.587
PLIN2-0.584
HEBP2-0.584
RAB13-0.582
HVCN1-0.582

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of VWC2 mRNA25088246
D001280AtrazineAtrazine results in decreased expression of VWC2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of VWC2 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of VWC2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of VWC2 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of VWC2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of VWC2 promoter22457795
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of VWC2 mRNA24763279
C018021cobaltous chloridecobaltous chloride results in decreased expression of VWC2 mRNA24386269
D003976DiazinonDiazinon results in increased methylation of VWC2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of VWC2 mRNA21266533
D004026DieldrinDieldrin results in increased expression of VWC2 mRNA20438755
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of VWC2 mRNA24763279
C568376MT19c compoundMT19c compound results in decreased expression of VWC2 mRNA21781307
C028473N-acetyl-4-benzoquinoneimineVWC2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D010936Plant ExtractsPlant Extracts results in decreased expression of VWC2 mRNA23557933
C009250sevofluranesevoflurane results in decreased expression of VWC2 mRNA26206149
D014212TretinoinTretinoin results in decreased expression of VWC2 mRNA20488242
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of VWC2 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of VWC2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of VWC2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0030514negative regulation of BMP signaling pathway-ISS17400546  
GO:0045666positive regulation of neuron differentiation-ISS17400546  
GO ID GO Term Qualifier Evidence PubMed
GO:0005604basement membrane-IEA-  
GO:0005614interstitial matrix-IEA-  
GO:0005615extracellular space-ISS17400546  
GO:0030054cell junction-IEA-  
GO:0032281AMPA glutamate receptor complex-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal