Gene: KCNH1

3756
EAG|EAG1|Kv10.1|TMBTS|ZLS1|h-eag|hEAG1
potassium voltage-gated channel subfamily H member 1
protein-coding
1q32.2
Ensembl:ENSG00000143473 MIM:603305 Vega:OTTHUMG00000036309 UniprotKB:O95259
NG_029777.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.621e-1 (AD)  5.033e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1501551chr1:211003580 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1501558chr1:210953065 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCN8A0.96
PCDHAC20.954
FAM78B0.948
MTUS20.941
GRM50.94
LHFPL40.934
NCR3LG10.933
PPM1E0.931
SLC4A80.925
HS6ST30.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.638
ROM1-0.635
COPZ2-0.628
HEY2-0.611
STON2-0.6
MYL3-0.595
GNG5-0.584
RNF135-0.579
AGTRAP-0.579
S100A16-0.577

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00637AstemizoleSmall Molecule68844-77-9Approved|WithdrawnTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of KCNH1 mRNA19933214
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCNH1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNH1 mRNA16483693
D016589AstemizoleAstemizole binds to and results in decreased activity of KCNH1 protein18497958
D016589AstemizoleAstemizole binds to KCNH1 protein18471075
D016589AstemizoleAstemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]17520698
D016589AstemizoleAstemizole results in decreased activity of KCNH1 protein14985237|1681684
D001280AtrazineAtrazine results in decreased expression of KCNH1 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of KCNH1 mRNA22323515
D001464BariumBarium results in decreased activity of KCNH1 protein10896755
D001544BenperidolBenperidol binds to and results in decreased activity of KCNH1 protein17982510
D001549BenzamidesBenzamides analog binds to and results in decreased activity of KCNH1 protein17982510
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of KCNH1 mRNA26377693
D004958Estradiol[Estradiol co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA19351862
D004958Estradiol[Estradiol co-treated with fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA19351862
D004958Estradiol[Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA19351862
D004958EstradiolEstradiol results in increased expression of KCNH1 mRNA19351862
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of KCNH1 mRNA]19351862
C006780bisphenol Abisphenol A results in decreased expression of KCNH1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KCNH1 gene28505145
D002090ButyrophenonesButyrophenones binds to and results in decreased activity of KCNH1 protein17982510
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of KCNH1 mRNA12734012
D002509CephaloridineCephaloridine results in increased expression of KCNH1 mRNA18500788
C040463desmethylastemizoledesmethylastemizole results in decreased activity of KCNH1 protein16816845
D003989DibenzoxazepinesDibenzoxazepines binds to and results in decreased activity of KCNH1 protein17982510
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KCNH1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KCNH1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of KCNH1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of KCNH1 mRNA27392435
C063968E 4031E 4031 binds to and results in decreased activity of KCNH1 protein18497958
C063968E 4031E 4031 binds to KCNH1 protein18471075
C070081fulvestrant[Estradiol co-treated with fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA19351862
C070081fulvestrant[fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA19351862
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of KCNH1 mRNA]19351862
C070081fulvestrantfulvestrant results in decreased expression of KCNH1 mRNA19351862
D017313FenretinideFenretinide results in increased expression of KCNH1 mRNA28973697
D007099ImipramineImipramine binds to and results in decreased activity of KCNH1 protein18497958
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of KCNH1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KCNH1 mRNA24796395
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of KCNH1 mRNA12057914
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KCNH1 mRNA"20188158
C076170mizolastinemizolastine results in decreased activity of KCNH1 protein11082114
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of KCNH1 mRNA17616710
D010126OzoneOzone results in increased expression of KCNH1 mRNA28623178
D010622PhencyclidinePhencyclidine results in decreased expression of KCNH1 mRNA12105081
D010880PiperidinesPiperidines metabolite binds to and results in decreased activity of KCNH1 protein17982510
D011192Potassium DichromatePotassium Dichromate results in increased expression of KCNH1 mRNA23608068
D011802QuinidineQuinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]17520698
C059514resveratrolresveratrol results in decreased expression of KCNH1 mRNA25888808
D012969Sodium FluorideSodium Fluoride results in decreased expression of KCNH1 mRNA27862939
D013469SulpirideSulpiride binds to and results in decreased activity of KCNH1 protein17982510
D013629Tamoxifen[Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA19351862
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA19351862
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KCNH1 mRNA19933214|2135428
C011559tributyltintributyltin results in decreased expression of KCNH1 mRNA27614199
D014635Valproic AcidValproic Acid results in decreased methylation of KCNH1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KCNH1 gene25560391
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]17520698
C088658zoledronic acidzoledronic acid results in decreased expression of KCNH1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000155phosphorelay sensor kinase activity-IEA-  
GO:0005249voltage-gated potassium channel activity-IBA21873635  
GO:0005251delayed rectifier potassium channel activity-IDA22732247  27005320  27325704  
GO:0005515protein binding-IPI20708613  25416956  
GO:0005516calmodulin binding-IEA-  
GO:0019901protein kinase binding-IEA-  
GO:0030551cyclic nucleotide bindingNOTISS-  
GO:0042802identical protein binding-IEA-  
GO:0044325ion channel binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:007188914-3-3 protein binding-IEA-  
GO:1902936phosphatidylinositol bisphosphate binding-IDA27005320  
GO ID GO Term Qualifier Evidence PubMed
GO:0000160phosphorelay signal transduction system-IEA-  
GO:0001964startle response-IEA-  
GO:0006813potassium ion transport-TAS9738473  
GO:0007520myoblast fusion-TAS9738473  
GO:0023014signal transduction by protein phosphorylation-IEA-  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0042127regulation of cell proliferation-IMP23881642  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0048015phosphatidylinositol-mediated signaling-IMP27005320  
GO:0071277cellular response to calcium ion-IMP27005320  27325704  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IDA22732247  27005320  27325704  
GO ID GO Term Qualifier Evidence PubMed
GO:0005637nuclear inner membrane-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA27005320  27325704  
GO:0005887integral component of plasma membrane-IMP22732247  
GO:0008076voltage-gated potassium channel complex-IDA22732247  
GO:0009986cell surface-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0030673axolemma-IEA-  
GO:0031901early endosome membrane-IDA22841712  
GO:0042734presynaptic membrane-IEA-  
GO:0043204perikaryon-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045211postsynaptic membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296072Voltage gated Potassium channelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal