Gene: SLC26A5

375611
DFNB61|PRES
solute carrier family 26 member 5
protein-coding
7q22.1
Ensembl:ENSG00000170615 MIM:604943 Vega:OTTHUMG00000149911 UniprotKB:P58743
NG_023055.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.488e-1 (AD)  4.085e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR6C740.469
SLC24A10.444
PRTG0.442
UACA0.427
KDR0.426
RAI140.423
OTUD7B0.412
TNS10.41
FLNB0.408
VNN30.403

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM57B-0.381
RIPPLY2-0.373
KCNC4-0.37
GGH-0.367
TRNP1-0.366
FBLL1-0.366
RTN2-0.366
SYT3-0.356
KCNK12-0.354
SBK1-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC26A5 mRNA"25614096
D000082AcetaminophenAcetaminophen affects the expression of SLC26A5 mRNA25064622
D020106AcrylamideAcrylamide results in decreased expression of SLC26A5 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC26A5 gene27153756
D000638AmiodaroneAmiodarone affects the expression of SLC26A5 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC26A5 mRNA16483693
D001507BeclomethasoneBeclomethasone results in increased expression of SLC26A5 mRNA23656298
C006780bisphenol Abisphenol A affects the expression of SLC26A5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SLC26A5 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SLC26A5 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SLC26A5 promoter22457795
D002746ChlorpromazineChlorpromazine affects the expression of SLC26A5 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of SLC26A5 mRNA25064622
D004147DioxinsDioxins affects the expression of SLC26A5 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC26A5 mRNA25064622
D005419FlavonoidsFlavonoids results in decreased expression of SLC26A5 mRNA18035473
D015248GemfibrozilGemfibrozil results in decreased expression of SLC26A5 mRNA20006695
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SLC26A5 mRNA26846883
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC26A5 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC26A5 mRNA26011545
D010269ParaquatParaquat affects the expression of SLC26A5 mRNA25064622
D059808PolyphenolsPolyphenols results in decreased expression of SLC26A5 mRNA16293270
D011189Potassium ChloridePotassium Chloride results in decreased expression of SLC26A5 mRNA21624428
D011189Potassium ChloridePotassium Chloride results in increased expression of SLC26A5 mRNA21624428
C009277sodium arsenatesodium arsenate results in decreased expression of SLC26A5 mRNA23922661
D012965Sodium ChlorideSodium Chloride results in decreased expression of SLC26A5 mRNA21624428
D012980Sodium SalicylateSodium Salicylate results in increased expression of SLC26A5 mRNA19173110
D012980Sodium SalicylateSodium Salicylate results in increased expression of SLC26A5 protein19173110
D013752TetracyclineTetracycline affects the expression of SLC26A5 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of SLC26A5 mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SLC26A5 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC26A5 mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of SLC26A5 mRNA25064622
C025643vinclozolinvinclozolin results in decreased expression of SLC26A5 mRNA23555832
D015032ZincZinc deficiency results in increased expression of SLC26A5 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005254chloride channel activity-IBA21873635  
GO:0008134transcription factor binding-IEA-  
GO:0008271secondary active sulfate transmembrane transporter activity-IEA-  
GO:0015106bicarbonate transmembrane transporter activity-IBA21873635  
GO:0015116sulfate transmembrane transporter activity-IBA21873635  
GO:0015301anion:anion antiporter activity-IBA21873635  
GO:0019531oxalate transmembrane transporter activity-IBA21873635  
GO:0030507spectrin binding-IEA-  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002931response to ischemia-IEA-  
GO:0007605sensory perception of sound-IMP12719379  
GO:0008360regulation of cell shape-IEA-  
GO:0009751response to salicylic acid-IEA-  
GO:0010996response to auditory stimulus-IEA-  
GO:0015701bicarbonate transport-IBA21873635  
GO:0015755fructose transmembrane transport-IEA-  
GO:0019532oxalate transport-IBA21873635  
GO:0019532oxalate transport-IEA-  
GO:0034766negative regulation of ion transmembrane transport-IEA-  
GO:0035864response to potassium ion-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0045793positive regulation of cell size-IEA-  
GO:0051262protein tetramerization-IEA-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:0090102cochlea development-IEA-  
GO:0097066response to thyroid hormone-IEA-  
GO:1902074response to salt-IEA-  
GO:1902358sulfate transmembrane transport-IBA21873635  
GO:1902358sulfate transmembrane transport-IEA-  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:2000147positive regulation of cell motility-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016328lateral plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665419Prenatal smoke exposure: effects on infant auditory system and placental gene expression. (2013 Jul-Aug)Katbamna BNeurotoxicol Teratol