Gene: KCNJ2

3759
ATFB9|HHBIRK1|HHIRK1|IRK1|KIR2.1|LQT7|SQT3
potassium voltage-gated channel subfamily J member 2
protein-coding
17q24.3
Ensembl:ENSG00000123700 MIM:600681 Vega:OTTHUMG00000180351 UniprotKB:P63252
NG_008798.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.709e-1 (AD)  3.957e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAT40.76
BVES0.716
TANC10.715
DPYD0.714
C18orf540.707
CNKSR30.696
SHROOM40.696
ELK40.695
ABCG10.686
ATL30.684

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.377
SPDEF-0.375
GNG13-0.37
CRYBA2-0.368
NT5M-0.353
KREMEN2-0.351
FOXP3-0.335
SLC25A10-0.333
SLC29A4-0.331
WNT7B-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of KCNJ2 mRNA23792671
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of KCNJ2 mRNA"23196670
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of KCNJ2 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNJ2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNJ2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNJ2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNJ2 mRNA"27188386
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of KCNJ2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KCNJ2 mRNA]17585979
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of KCNJ2 mRNA"23195993
D000638AmiodaroneAmiodarone results in increased expression of KCNJ2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNJ2 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride affects the activity of KCNJ2 protein11687881
D001151ArsenicArsenic results in decreased expression of KCNJ2 mRNA16835338
C006632arsenic trioxidearsenic trioxide results in decreased expression of KCNJ2 protein22853924
C006632arsenic trioxideLy-364947 inhibits the reaction [arsenic trioxide results in decreased expression of KCNJ2 protein]22853924
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of KCNJ2 mRNA"18687144
D001262AtenololKCNJ2 gene affects the susceptibility to Atenolol15028050
D001464BariumBarium inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]10967048
D001464BariumBarium inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]11283229
D001464BariumBarium inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]15958527|1734778
D001464BariumBarium results in decreased activity of KCNJ2 protein12598232
D001464BariumBarium results in decreased activity of KCNJ2 protein17699636
D001464BariumBarium results in decreased activity of KCNJ2 protein23261645
C024986barium chloridebarium chloride inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]11087224
C487081belinostatbelinostat results in decreased expression of KCNJ2 mRNA27188386
D001554BenzeneBenzene affects the expression of KCNJ2 mRNA21147609
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KCNJ2 mRNA22316170
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of KCNJ2 mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of KCNJ2 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNJ2 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of KCNJ2 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of KCNJ2 mRNA26921506
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KCNJ2 mRNA21457566
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of KCNJ2 mRNA20360939
D002586CesiumCesium inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]10967048
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of KCNJ2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KCNJ2 mRNA]17585979
D003630DaunorubicinDaunorubicin results in increased expression of KCNJ2 mRNA26537877|2894005
C014347decitabinedecitabine results in decreased expression of KCNJ2 mRNA27915011
D003703DemecolcineDemecolcine results in increased expression of KCNJ2 mRNA23649840
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNJ2 promoter23359474
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNJ2 promoter23359474
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of KCNJ2 mRNA20920545
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of KCNJ2 mRNA20360939
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of KCNJ2 mRNA17374397
D004237DiuronDiuron metabolite results in increased expression of KCNJ2 mRNA24172598
D004317DoxorubicinDoxorubicin affects the expression of KCNJ2 mRNA25529476
D004317DoxorubicinDoxorubicin results in increased expression of KCNJ2 mRNA26537877|2894005
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KCNJ2 mRNA23649840
D005054EugenolEugenol results in decreased expression of KCNJ2 mRNA17374397
D005557FormaldehydeFormaldehyde results in increased expression of KCNJ2 mRNA23649840
D006221HalothaneKCNJ2 affects the susceptibility to Halothane17546530
C544151jinfukangjinfukang results in decreased expression of KCNJ2 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of KCNJ2 mRNA26582142
C520284Ly-364947Ly-364947 inhibits the reaction [arsenic trioxide results in decreased expression of KCNJ2 protein]22853924
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KCNJ2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KCNJ2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KCNJ2 mRNA"20188158
D008942MitoxantroneMitoxantrone results in increased expression of KCNJ2 mRNA26537877|2894005
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in decreased expression of KCNJ2 protein]22853924
D009532NickelNickel results in increased expression of KCNJ2 mRNA23195993
C029938nickel sulfatenickel sulfate results in decreased expression of KCNJ2 mRNA16780908|1737439
D009599NitroprussideNitroprusside affects the activity of KCNJ2 protein14993195
D010081OxazoloneOxazolone results in decreased expression of KCNJ2 mRNA17374397
D010100OxygenOxygen deficiency results in increased expression of KCNJ2 mRNA24236059
D010100Oxygen[Oxygen deficiency co-treated with SCH 442416] results in increased expression of KCNJ2 mRNA24431311
D052638Particulate MatterParticulate Matter results in decreased expression of KCNJ2 mRNA22178795
D010575PesticidesPesticides results in decreased methylation of KCNJ2 gene28396702
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNJ2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KCNJ2 mRNA26272509
D011188PotassiumBarium inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]10967048
D011188PotassiumCesium inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]10967048
D011188PotassiumKCNJ2 protein results in increased transport of Potassium10967048
D011188PotassiumBarium inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]11283229
D011188PotassiumKCNJ2 protein results in increased transport of Potassium11283229
D011188PotassiumBarium inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]15958527|1734778
D011188PotassiumKCNJ2 protein results in increased transport of Potassium12598232|1595852
D011188PotassiumKCNJ2 protein results in increased transport of Potassium12118013
D011188Potassiumbarium chloride inhibits the reaction [KCNJ2 protein results in increased transport of Potassium]11087224
D011188PotassiumKCNJ2 protein results in increased transport of Potassium11087224
D011189Potassium ChloridePotassium Chloride affects the activity of KCNJ2 protein11687881
D011433PropranololKCNJ2 gene affects the susceptibility to Propranolol15028050
C416650SCH 442416[Oxygen deficiency co-treated with SCH 442416] results in increased expression of KCNJ2 mRNA24431311
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KCNJ2 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of KCNJ2 mRNA22714537
D013739TestosteroneTestosterone results in increased expression of KCNJ2 protein17054656
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KCNJ2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCNJ2 mRNA26377647
C042172thallium nitratethallium nitrate affects the activity of KCNJ2 protein11687881
D019284ThapsigarginThapsigargin results in increased expression of KCNJ2 mRNA22378314
D014212TretinoinTretinoin results in decreased expression of KCNJ2 mRNA23724009
D014212TretinoinTretinoin results in increased expression of KCNJ2 mRNA21934132
C062527tribromoethanolKCNJ2 affects the susceptibility to tribromoethanol17546530
C012589trichostatin Atrichostatin A results in decreased expression of KCNJ2 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of KCNJ2 mRNA24935251
D014260TriclosanTriclosan results in increased expression of KCNJ2 mRNA28940058
D014520UrethaneUrethane results in decreased expression of KCNJ2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNJ2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of KCNJ2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of KCNJ2 mRNA28001369
C111237vorinostatvorinostat results in decreased expression of KCNJ2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005242inward rectifier potassium channel activity-IBA21873635  
GO:0005242inward rectifier potassium channel activity-IDA11371347  12086641  20921230  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IDA12086641  
GO:0015467G-protein activated inward rectifier potassium channel activity-TAS-  
GO:0042802identical protein binding-IEA-  
GO:0086008voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization-IMP11371347  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-IDA20921230  
GO:0010107potassium ion import-IBA21873635  
GO:0010107potassium ion import-IDA11371347  
GO:0014861regulation of skeletal muscle contraction via regulation of action potential-IMP11371347  
GO:0015693magnesium ion transport-IEA-  
GO:0030007cellular potassium ion homeostasis-TAS20086079  
GO:0034765regulation of ion transmembrane transport-IBA21873635  
GO:0051289protein homotetramerization-IDA20921230  
GO:0055119relaxation of cardiac muscle-IMP11371347  
GO:0060075regulation of resting membrane potential-TAS20086079  
GO:0060306regulation of membrane repolarization-IDA11371347  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO:0071805potassium ion transmembrane transport-IDA12086641  
GO:0086002cardiac muscle cell action potential involved in contraction-IMP11371347  
GO:0086004regulation of cardiac muscle cell contraction-IEA-  
GO:0086011membrane repolarization during action potential-IMP11371347  
GO:0086012membrane depolarization during cardiac muscle cell action potential-TAS20086079  
GO:0086013membrane repolarization during cardiac muscle cell action potential-IMP11371347  
GO:0086013membrane repolarization during cardiac muscle cell action potential-TAS20086079  
GO:0086091regulation of heart rate by cardiac conduction-IMP15761194  
GO:0090076relaxation of skeletal muscle-IMP11371347  
GO:1901381positive regulation of potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005790smooth endoplasmic reticulum-IEA-  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7696590  
GO:0008076voltage-gated potassium channel complex-IDA12086641  
GO:0014704intercalated disc-IEA-  
GO:0030315T-tubule-IEA-  
GO:0031224intrinsic component of membrane-IDA20921230  
GO:0043025neuronal cell body-IEA-  
GO:0043197dendritic spine-IEA-  
KEGG ID KEGG Term
hsa04971Gastric acid secretion
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1296041Activation of G protein gated Potassium channelsTAS
R-HSA-1296053Classical Kir channelsTAS
R-HSA-1296059G protein gated Potassium channelsTAS
R-HSA-1296065Inwardly rectifying K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576886Phase 4 - resting membrane potentialTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977444GABA B receptor activationTAS
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19603079Influence of smoking on colonic gene expression profile in Crohn's disease. (2009 Jul 15)Nielsen OHPLoS One
23284291Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (2012)Hancock DBPLoS Genet