Gene: KCNJ6

3763
BIR1|GIRK-2|GIRK2|KATP-2|KATP2|KCNJ7|KIR3.2|KPLBS|hiGIRK2
potassium voltage-gated channel subfamily J member 6
protein-coding
21q22.13
Ensembl:ENSG00000157542 MIM:600877 Vega:OTTHUMG00000086667 UniprotKB:P48051
NG_029892.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
7   
3.876e-1 (AD)  4.283e-1 (ND)   (Frontal_Cortex)
6.018e-1 (AD)  1.251e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2835872chr21:37654970 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABBR20.895
KCNB10.89
GFRA20.888
CHRM30.888
PRICKLE10.887
SATB20.885
THRB0.883
KIAA1549L0.883
RTN4RL10.882
SSTR30.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.587
ACAP1-0.58
REST-0.574
WWTR1-0.562
HEY2-0.558
YES1-0.557
ARHGEF5-0.556
SNHG18-0.553
LRAT-0.539
MBNL3-0.536

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB11633IsavuconazoleSmall Molecule241479-67-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0293704-toluidine4-toluidine results in decreased expression of KCNJ6 mRNA27638505
D000109AcetylcholineAcetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]10666054
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCNJ6 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of KCNJ6 mRNA21298039
D005680gamma-Aminobutyric Acid[gamma-Aminobutyric Acid results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]11125035
D000657AmoxapineAmoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]22164246
D017639Asbestos, Amosite"Asbestos, Amosite results in increased expression of KCNJ6 mRNA"23917077
D001418BaclofenKCNJ6 results in increased susceptibility to Baclofen12836919
D001464BariumBarium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]10666054
C024986barium chloridebarium chloride inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]17021048
C024986barium chloridebarium chloride results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein]17021048
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KCNJ6 mRNA21839799
C110027beta-apocarotenoid-14',13'-dioxygenase"[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]"12684268
C110027beta-apocarotenoid-14',13'-dioxygenase"Fluoxetine inhibits the reaction [[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]]"12684268
C006780bisphenol Abisphenol A results in decreased expression of KCNJ6 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of KCNJ6 mRNA26079696
D002217Carbachol[Carbachol binds to and results in increased activity of CHRM2 protein] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]17021048
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of KCNJ6 mRNA24763279
D003042CocaineCocaine results in decreased expression of KCNJ6 mRNA12629581
D003042CocaineCocaine affects the expression of KCNJ6 mRNA20187946
D003042CocaineCocaine results in increased expression of KCNJ6 mRNA17898221
C024989coenzyme Q10KCNJ6 gene mutant form results in decreased abundance of coenzyme Q1015256069
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of KCNJ6 mRNA20971185
D016578Crack CocaineCrack Cocaine results in increased expression of KCNJ6 mRNA12629581
D003471CuprizoneCuprizone results in decreased expression of KCNJ6 mRNA26577399
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of KCNJ6 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of KCNJ6 mRNA27392435
D004298DopamineKCNJ6 gene mutant form results in decreased abundance of Dopamine15256069
D000068736Duloxetine HydrochlorideDuloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]22164246
D000431EthanolEthanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]22164246
D000431EthanolEthanol results in increased activity of KCNJ6 protein16626657
D000431EthanolSertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]]22164246
D000431EthanolEthanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]18977371
D000431EthanolEthosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]18977371
D005013EthosuximideEthosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]18977371
D005013EthosuximideEthosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]18977371
D005473FluoxetineFluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]12684268
D005473FluoxetineFluoxetine inhibits the reaction [KCNJ6 protein results in increased transport of Potassium]12684268
D005473Fluoxetine"Fluoxetine inhibits the reaction [[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]]"12684268
C040029gabapentin[gabapentin binds to and results in increased activity of [GABBR1 protein alternative form binds to GABBR2 protein]] results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]11125035
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of KCNJ6 mRNA24763279
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of KCNJ6 mRNA27392435
D007854LeadLead results in increased expression of KCNJ6 mRNA19921347
D008694MethamphetamineMethamphetamine results in decreased expression of KCNJ6 mRNA21886566
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KCNJ6 mRNA23203475
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of KCNJ6 mRNA26558463
D0156551-Methyl-4-phenylpyridiniumKCNJ6 protein promotes the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]15888489
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"KCNJ6 affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"8172626
D008803MianserinMianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]22164246
C035133mirtazapinemirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]22164246
C051752nefazodonenefazodone affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]22164246
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of KCNJ6 mRNA20971185
D010269ParaquatParaquat results in increased expression of KCNJ6 mRNA22563483
D017374ParoxetineParoxetine results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein]17072103
D017374ParoxetineParoxetine results in decreased activity of [KCNJ6 protein binds to KCNJ5 protein]17072103
D017374ParoxetineParoxetine results in decreased activity of [KCNJ6 protein binds to KCNJ6 protein]17072103
D011188PotassiumAcetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]10666054
D011188PotassiumBarium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]10666054
D011188Potassium[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium10666054
D011188PotassiumKCNJ6 protein results in increased transport of Potassium11707631
D011188Potassiumbarium chloride inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]17021048
D011188Potassium[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium17021048
D011188PotassiumTestosterone inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]17021048
D011188PotassiumEthosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]18977371
D011188PotassiumFluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]12684268
D011188PotassiumFluoxetine inhibits the reaction [KCNJ6 protein results in increased transport of Potassium]12684268
D011188Potassium[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium18977371
D011188Potassium[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium12684268
D011188PotassiumKCNJ6 protein results in increased transport of Potassium12684268
D011188PotassiumEthanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]18977371
D011188PotassiumEthosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]18977371
D011188Potassium[KCNJ6 protein binds to KCNJ3 protein] which results in increased transport of Potassium18977371
D011188Potassium"[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]"12684268
D011188Potassium"Fluoxetine inhibits the reaction [[beta-apocarotenoid-14',13'-dioxygenase results in increased activity of ADORA1 protein] promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]]"12684268
D011441PropylthiouracilPropylthiouracil results in decreased expression of KCNJ6 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of KCNJ6 mRNA24780913
D020280SertralineSertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]]22164246
D020280SertralineSertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]22164246
D013739TestosteroneTestosterone inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]17021048
D013739TestosteroneTestosterone results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein]17021048
D013739TestosteroneAR protein affects the reaction [Testosterone results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein]]17021048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KCNJ6 mRNA11489354
D013793Thallium[GRM8 protein results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]] which results in increased transport of Thallium22275899
D014050TolueneToluene results in decreased activity of KCNJ6 protein16626657
C030571ubiquinone 9KCNJ6 gene mutant form results in decreased abundance of ubiquinone 915256069
D014635Valproic AcidValproic Acid affects the expression of KCNJ6 mRNA25979313
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]22164246

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005242inward rectifier potassium channel activity-IBA21873635  
GO:0005242inward rectifier potassium channel activity-TAS7796919  
GO:0005515protein binding-IPI12297500  
GO:0015467G-protein activated inward rectifier potassium channel activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-TAS7796919  
GO:0010107potassium ion import-IBA21873635  
GO:0034765regulation of ion transmembrane transport-IBA21873635  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-HDA16780588  
GO:0005886plasma membrane-HDA16780588  
GO:0005886plasma membrane-TAS-  
GO:0008076voltage-gated potassium channel complex-TAS7796919  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1296041Activation of G protein gated Potassium channelsTAS
R-HSA-1296059G protein gated Potassium channelsTAS
R-HSA-1296065Inwardly rectifying K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977444GABA B receptor activationTAS
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22554406Family-based genome-wide association study of frontal theta oscillations identifies potassium channel gene KCNJ6. (2012 Aug)Kang SJGenes Brain Behav
23712313Genetics and alcoholism. (2013 Aug)Edenberg HJNat Rev Gastroenterol Hepatol
21307845KCNJ6 is associated with adult alcohol dependence and involved in gene x early life stress interactions in adolescent alcohol drinking. (2011 May)Clarke TKNeuropsychopharmacology
17135278Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. (2007 Jan 1)Saccone SFHum Mol Genet
25346042Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and post-operative analgesia, pain sensitivity, and nicotine dependence. (2014)Nishizawa DJ Pharmacol Sci
27613936High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)Fiatal SNicotine Tob Res
27993610A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. (2017 May)Kamarajan CInt J Psychophysiol