Gene: KCNJ11

3767
BIR|HHF2|IKATP|KIR6.2|MODY13|PHHI|TNDM3
potassium voltage-gated channel subfamily J member 11
protein-coding
11p15.1
Ensembl:ENSG00000187486 MIM:600937 Vega:OTTHUMG00000165914 UniprotKB:Q14654
NG_012446.1
PubMed
0   ANCO-SNPs
CD|ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.457e-1 (AD)  1.442e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03864215chr11:17408437KCNJ112.500e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLSTN30.925
SYT30.919
SULT4A10.917
TUBA4A0.915
GFOD20.914
SYNGR30.914
DIRAS10.912
ATP1A30.911
SYP0.911
APBA20.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.576
RAI14-0.55
YES1-0.544
MBNL3-0.515
HEY2-0.514
WWTR1-0.507
PARD3B-0.498
WEE1-0.494
CNN2-0.494
EBF1-0.491

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00222GlimepirideSmall Molecule93479-97-1ApprovedTarget
DB00308IbutilideSmall Molecule122647-31-8ApprovedTarget
DB00661VerapamilSmall Molecule52-53-9ApprovedTarget
DB00922LevosimendanSmall Molecule141505-33-1Approved|InvestigationalTarget
DB01119DiazoxideSmall Molecule364-98-7ApprovedTarget
DB01154ThiamylalSmall Molecule77-27-0ApprovedTarget
DB11633IsavuconazoleSmall Molecule241479-67-4Approved|InvestigationalTarget
DB01392YohimbineSmall Molecule146-48-5Approved|InvestigationalTarget
DB01016GlyburideSmall Molecule10238-21-8ApprovedTarget
DB00839TolazamideSmall Molecule1156-19-0Approved|InvestigationalTarget
DB01016GlyburideSmall Molecule10238-21-8ApprovedTarget
ID Drug Name Action PubMed
C5705347-chloro-3-(1-hydroxy-2-propyl)amino-4H-1,2,4-benzothiadiazine 1,1-dioxide"7-chloro-3-(1-hydroxy-2-propyl)amino-4H-1,2,4-benzothiadiazine 1,1-dioxide analog affects the activity of [ABCC8 protein binds to KCNJ11 protein]"22077416
D000082AcetaminophenAcetaminophen results in decreased expression of KCNJ11 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of KCNJ11 mRNA28959563
D000255Adenosine TriphosphateAdenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]28842488
D000255Adenosine TriphosphateKCNJ11 protein mutant form results in decreased susceptibility to Adenosine Triphosphate28842488
C031143AICA ribonucleotideKCNJ11 protein affects the susceptibility to AICA ribonucleotide24498880
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNJ11 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of KCNJ11 mRNA25929836
C006780bisphenol Abisphenol A affects the expression of KCNJ11 mRNA23328667
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of KCNJ11 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of KCNJ11 mRNA25181051
D002118CalciumDantrolene inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium]17189350
D002118CalciumKCNJ11 protein affects the abundance of Calcium17189350
D002118CalciumKCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]17189350
D002118CalciumW 7 inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium]17189350
C043211carvedilolcarvedilol results in decreased activity of KCNJ11 protein16325804
D002747Chlorpropamide[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide22209866
D003042CocaineKCNJ11 results in decreased susceptibility to Cocaine20443920
D003620DantroleneDantrolene inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium]17189350
D003847DeoxyglucoseGlyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]28842488
D003847Deoxyglucose[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]28842488
D003981DiazoxideDiazoxide results in decreased expression of KCNJ11 mRNA23200776
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of KCNJ11 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of KCNJ11 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of KCNJ11 mRNA21658437
D0192972,4-Dinitrophenol"2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]"15949470
D0192972,4-Dinitrophenol"Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]"15949470
D004280DobutamineKCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]17189350
D004280DobutamineKCNJ11 protein affects the susceptibility to Dobutamine17189350
D004317DoxorubicinDoxorubicin results in decreased expression of KCNJ11 mRNA19915844
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of KCNJ11 mRNA12655031
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of KCNJ11 gene16724327
D005419FlavonoidsFlavonoids results in increased expression of KCNJ11 mRNA18035473
D005907Gliclazide[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide22209866
C057619glimepiride[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride22209866
D005905Glyburide"Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]"15949470
D005905GlyburideGlyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]28842488
D005905GlyburideKCNJ11 protein mutant form results in decreased susceptibility to Glyburide28842488
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of KCNJ11 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KCNJ11 mRNA27432991
D008345ManganeseKCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]17189350
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of KCNJ11 mRNA16000145
C087255mitiglinide[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to mitiglinide22209866
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of KCNJ11 mRNA27935865
D016627OxidopamineOxidopamine results in increased expression of KCNJ11 mRNA15857625
D016627OxidopamineOxidopamine results in increased expression of KCNJ11 protein15857625
D009840OligomycinsGlyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]28842488
D009840Oligomycins[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]28842488
D000073878Palm OilPalm Oil results in decreased expression of KCNJ11 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of KCNJ11 mRNA23892564
D010695PhlorhizinPhlorhizin results in increased expression of KCNJ11 mRNA16123366
D010852PicrotoxinPicrotoxin results in decreased expression of KCNJ11 mRNA18021373
D010852PicrotoxinPicrotoxin results in decreased expression of KCNJ11 protein18021373
D010852PicrotoxinPicrotoxin results in increased expression of KCNJ11 mRNA18021373
D010852PicrotoxinPicrotoxin results in increased expression of KCNJ11 protein18021373
D020110PinacidilPinacidil promotes the reaction [KCNJ11 protein results in increased transport of Potassium]18420708
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of KCNJ11 mRNA27935865
D011188PotassiumKCNJ11 protein results in increased transport of Potassium10835035
D011188Potassium"2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]"15949470
D011188Potassium"Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]"15949470
D011188PotassiumKCNJ11 protein results in increased transport of Potassium10022826|1594947
D011188PotassiumPinacidil promotes the reaction [KCNJ11 protein results in increased transport of Potassium]18420708
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of KCNJ11 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of KCNJ11 mRNA24780913
D019269Phosphatidylinositol 4,5-Diphosphate"KCNJ11 protein mutant form results in increased susceptibility to Phosphatidylinositol 4,5-Diphosphate"28842488
D019269Phosphatidylinositol 4,5-Diphosphate"Phosphatidylinositol 4,5-Diphosphate results in increased activity of [KCNJ11 protein binds to ABCC9 protein]"28842488
C059514resveratrolKCNJ11 protein affects the susceptibility to resveratrol24498880
C059514resveratrolresveratrol results in increased activity of KCNJ11 protein24498880
C059514resveratrolresveratrol results in increased expression of KCNJ11 protein24498880
D012413Rubidium[KCNJ11 protein binds to ABCC8 protein] which results in increased export of Rubidium28842488
D012413Rubidium[KCNJ11 protein binds to ABCC9 protein] which results in increased export of Rubidium28842488
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KCNJ11 mRNA25895662
D016593TerfenadineTerfenadine results in decreased activity of [KCNJ11 protein binds to ABCC8 protein]10928959
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of KCNJ11 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KCNJ11 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KCNJ11 mRNA22808131
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KCNJ11 mRNA19969065
D014044Tolbutamide[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide22209866
D014044TolbutamideTolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]18025464
D014044TolbutamideTolbutamide results in decreased activity of KCNJ11 protein18025464
D014635Valproic AcidValproic Acid results in increased methylation of KCNJ11 gene29154799
D014635Valproic AcidValproic Acid affects the expression of KCNJ11 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of KCNJ11 gene25560391
C017967W 7W 7 inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium]17189350

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005242inward rectifier potassium channel activity-IBA21873635  
GO:0005249voltage-gated potassium channel activity-IDA19805355  
GO:0005515protein binding-IPI19805355  
GO:0005524ATP binding-ISS12860923  
GO:0005524ATP binding-TAS-  
GO:0008022protein C-terminus binding-IEA-  
GO:0015272ATP-activated inward rectifier potassium channel activity-IBA21873635  
GO:0015272ATP-activated inward rectifier potassium channel activity-ISS-  
GO:0030506ankyrin binding-IPI20610380  
GO:0030955potassium ion binding-TAS8923010  
GO:0031072heat shock protein binding-IEA-  
GO:0044325ion channel binding-IPI20610380  
GO ID GO Term Qualifier Evidence PubMed
GO:0002931response to ischemia-IEA-  
GO:0006006glucose metabolic process-IMP8923010  15115830  
GO:0010107potassium ion import-IBA21873635  
GO:0010107potassium ion import-ISS-  
GO:0032355response to estradiol-IEA-  
GO:0033198response to ATP-IDA15583126  18073297  
GO:0033574response to testosterone-IEA-  
GO:0034765regulation of ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IDA18073297  
GO:0042493response to drug-IMP18073297  
GO:0046676negative regulation of insulin secretion-IMP8923010  
GO:0050796regulation of insulin secretion-IMP15115830  
GO:0050796regulation of insulin secretion-TAS-  
GO:0050877nervous system process-IMP15115830  18073297  
GO:0071316cellular response to nicotine-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0071805potassium ion transmembrane transport-IDA19805355  
GO:1903078positive regulation of protein localization to plasma membrane-IEA-  
GO:2001259positive regulation of cation channel activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005635nuclear envelope-IEA-  
GO:0005739mitochondrion-IEA-  
GO:0005768endosome-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IDA19805355  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8923010  
GO:0008282inward rectifying potassium channel-IDA19805355  20610380  
GO:0008282inward rectifying potassium channel-ISS-  
GO:0014704intercalated disc-IEA-  
GO:0030315T-tubule-ISS-  
GO:0030673axolemma-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0070852cell body fiber-IEA-  
KEGG ID KEGG Term
hsa04930Type II diabetes mellitus
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296025ATP sensitive Potassium channelsTAS
R-HSA-1296065Inwardly rectifying K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1430728MetabolismTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-397014Muscle contractionTAS
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5683177Defective ABCC8 can cause hypoglycemias and hyperglycemiasTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20712903Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (2010 Aug 16)Morgan ARBMC Med Genet
26304961Interactive Effect of the KCNJ11 Ile337Val Polymorphism and Cigarette Smoking on the Antihypertensive Response to Irbesartan in Chinese Hypertensive Patients. (2016 May)Jiang SAm J Hypertens
20443920Targeted disruption of K(ATP) channels aggravates cardiac toxicity in cocaine abuse. (2009 Oct)Reyes SClin Transl Sci
19020324Clinical risk factors, DNA variants, and the development of type 2 diabetes. (2008 Nov 20)Lyssenko VN Engl J Med
25516658Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan. (2014 Dec 14)Kuruma SWorld J Gastroenterol
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res