Gene: KCNK1

3775
DPK|HOHO|K2P1|K2p1.1|KCNO1|TWIK-1|TWIK1
potassium two pore domain channel subfamily K member 1
protein-coding
1q42.2
Ensembl:ENSG00000135750 MIM:601745 Vega:OTTHUMG00000037923 UniprotKB:O00180
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.324e-1 (AD)  7.270e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP2K40.942
DCAF60.941
BTBD100.94
GLS0.939
PAK10.937
PCSK20.935
TMEM2460.933
GABRG20.928
NSF0.928
PPP3CB0.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.53
PARD3B-0.527
MBNL3-0.522
REST-0.518
YES1-0.514
ASB4-0.514
MYL3-0.505
COPZ2-0.503
MYOM1-0.502
CSAG1-0.496

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00308IbutilideSmall Molecule122647-31-8ApprovedTarget
DB00908QuinidineSmall Molecule56-54-2Approved|InvestigationalTarget
DB01346Quinidine barbiturateSmall Molecule-ApprovedTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of KCNK1 mRNA"27413110
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of KCNK1 mRNA"21394737
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KCNK1 mRNA"15215175
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of KCNK1 mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of KCNK1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of KCNK1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KCNK1 mRNA22100608
D000638AmiodaroneAmiodarone results in increased expression of KCNK1 mRNA15520326
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNK1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of KCNK1 mRNA25929836
D001464BariumBarium inhibits the reaction [KCNK1 protein results in increased transport of Potassium]16847696
D001464BariumBarium inhibits the reaction [KCNK1 protein results in increased transport of Sodium]16847696
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of KCNK1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCNK1 mRNA22228805
C452139BIRB 796BIRB 796 results in decreased expression of KCNK1 mRNA24303162
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of KCNK1 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of KCNK1 mRNA25912373
D002220CarbamazepineCarbamazepine affects the expression of KCNK1 mRNA25979313
D002737ChloropreneChloroprene results in increased expression of KCNK1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNK1 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of KCNK1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of KCNK1 mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of KCNK1 mRNA20106945|2798913
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of KCNK1 mRNA]21095227
D003907DexamethasoneDexamethasone results in increased expression of KCNK1 mRNA19344079
D003976DiazinonDiazinon results in increased methylation of KCNK1 gene22964155
D002945CisplatinKCNK1 protein affects the susceptibility to Cisplatin16217747
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of KCNK1 mRNA20920545
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KCNK1 mRNA24535843
C118739entinostatentinostat results in increased expression of KCNK1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KCNK1 mRNA15576828|1755790
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNK1 mRNA20938992
C039281furanfuran results in increased expression of KCNK1 mRNA27387713
D017313FenretinideFenretinide results in increased expression of KCNK1 mRNA28973697
D007854LeadLead results in increased expression of KCNK1 mRNA19921347
C018091maduramicinmaduramicin results in increased expression of KCNK1 mRNA29128925
C042720mercuric bromidemercuric bromide results in increased expression of KCNK1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNK1 mRNA20938992
D008727MethotrexateKCNK1 protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KCNK1 mRNA28001369
C523184mocetinostatmocetinostat results in increased expression of KCNK1 mRNA27255383
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KCNK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KCNK1 mRNA"25554681
D009538NicotineNicotine results in decreased expression of KCNK1 mRNA11478936
D010126OzoneOzone results in increased expression of KCNK1 mRNA17095637
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of KCNK1 mRNA23602845
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KCNK1 mRNA24535843
D010634PhenobarbitalKCNK1 results in decreased susceptibility to Phenobarbital23291559
D010634PhenobarbitalNR1I3 gene mutant form inhibits the reaction [Phenobarbital promotes the reaction [RXRA protein binds to KCNK1 promoter]]23291559
D010634PhenobarbitalNR1I3 gene mutant form inhibits the reaction [Phenobarbital results in increased expression of KCNK1 mRNA]23291559
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of KCNK1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of KCNK1 mRNA23091169
D010634PhenobarbitalPhenobarbital promotes the reaction [NR1I3 protein binds to KCNK1 promoter]23291559
D010634PhenobarbitalPhenobarbital promotes the reaction [RXRA protein binds to KCNK1 promoter]23291559
D010634PhenobarbitalPhenobarbital results in increased expression of KCNK1 mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital results in increased expression of KCNK1 protein23291559
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KCNK1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of KCNK1 mRNA17426115
D011188PotassiumBarium inhibits the reaction [KCNK1 protein results in increased transport of Potassium]16847696
D011188PotassiumKCNK1 protein results in increased transport of Potassium16847696
D011188PotassiumQuinidine affects the reaction [KCNK1 protein results in increased transport of Potassium]16847696
D011374ProgesteroneProgesterone results in decreased expression of KCNK1 mRNA19690047
C045950propiconazolepropiconazole results in increased expression of KCNK1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of KCNK1 mRNA24780913
D011802QuinidineQuinidine affects the reaction [KCNK1 protein results in increased transport of Potassium]16847696
D011802QuinidineQuinidine inhibits the reaction [KCNK1 protein results in increased transport of Sodium]16847696
D015474IsotretinoinIsotretinoin results in decreased expression of KCNK1 mRNA20436886
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of KCNK1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog affects the expression of KCNK1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KCNK1 mRNA23806026
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of KCNK1 mRNA]21095227
D012964SodiumBarium inhibits the reaction [KCNK1 protein results in increased transport of Sodium]16847696
D012964SodiumKCNK1 protein results in increased transport of Sodium16847696
D012964SodiumQuinidine inhibits the reaction [KCNK1 protein results in increased transport of Sodium]16847696
D053260SootSoot results in increased expression of KCNK1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCNK1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCNK1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of KCNK1 mRNA25975270
D019284ThapsigarginThapsigargin results in decreased expression of KCNK1 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of KCNK1 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of KCNK1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of KCNK1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of KCNK1 mRNA24935251|2627250
D014415TunicamycinTunicamycin results in decreased expression of KCNK1 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KCNK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of KCNK1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of KCNK1 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of KCNK1 mRNA21427059
D014640VancomycinVancomycin results in decreased expression of KCNK1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KCNK1 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of KCNK1 mRNA25423262
C029297vinylidene chloridevinylidene chloride results in decreased expression of KCNK1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005242inward rectifier potassium channel activity-TAS8605869  
GO:0005249voltage-gated potassium channel activityNOTIDA21653227  
GO:0005267potassium channel activity-IDA22282804  
GO:0005267potassium channel activity-TAS-  
GO:0005272sodium channel activity-IDA21653227  
GO:0005515protein binding-IPI20498050  
GO:0022841potassium ion leak channel activity-IBA21873635  
GO:0022841potassium ion leak channel activity-IDA21653227  
GO:0042802identical protein binding-IPI20498050  22282804  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-TAS8605869  
GO:0030322stabilization of membrane potential-IBA21873635  
GO:0035094response to nicotine-IEA-  
GO:0035725sodium ion transmembrane transport-IDA21653227  
GO:0060075regulation of resting membrane potential-IMP21653227  
GO:0061337cardiac conduction-TAS-  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IDA21653227  22282804  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA21653227  
GO:0005887integral component of plasma membrane-ISS-  
GO:0008076voltage-gated potassium channel complex-TAS8605869  
GO:0016021integral component of membrane-IDA22282804  
GO:0016324apical plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0031526brush border membrane-IEA-  
GO:0034705potassium channel complex-IDA22282804  
GO:0043204perikaryon-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045202synapse-IEA-  
GO:0055037recycling endosome-IEA-  
GO:1902937inward rectifier potassium channel complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296346Tandem pore domain potassium channelsTAS
R-HSA-1299308Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)TAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576886Phase 4 - resting membrane potentialTAS
R-HSA-5576891Cardiac conductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19948975Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)McGeachie MCirculation