Gene: KCNMA1

3778
BKTM|CADEDS|KCa1.1|MaxiK|PNKD3|SAKCA|SLO|SLO-ALPHA|SLO1|bA205K10.1|hSlo|mSLO1
potassium calcium-activated channel subfamily M alpha 1
protein-coding
10q22.3
Ensembl:ENSG00000156113 MIM:600150 Vega:OTTHUMG00000018543 UniprotKB:Q12791
NG_012270.1
PubMed|SNP Mapped
5   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.225e-1 (AD)  7.642e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12219105chr10:77413782 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2077641chr10:77386358 (GRCh38.p7)G>A / G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs592676chr10:77294199 (GRCh38.p7)T>Anicotine dependenceSNV(Single Nucleotide Variation)
rs717207chr10:77283606 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10824494chr10:77158539 (GRCh38.p7)C>A / C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYH100.973
TLN20.971
RBFOX20.97
BTRC0.969
SYT70.968
DOCK30.966
CELF20.965
PI4KA0.965
UNC13A0.965
ATCAY0.964

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.529
RAI14-0.516
OR4F5-0.511
SNHG18-0.501
MYL3-0.496
YES1-0.495
COPZ2-0.491
CSAG1-0.483
REST-0.479
RAB13-0.47

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00356ChlorzoxazoneSmall Molecule95-25-0ApprovedTarget
DB00436BendroflumethiazideSmall Molecule73-48-3ApprovedTarget
DB00774HydroflumethiazideSmall Molecule135-09-1Approved|InvestigationalTarget
DB00999HydrochlorothiazideSmall Molecule58-93-5ApprovedTarget
DB01003Cromoglicic acidSmall Molecule16110-51-3ApprovedTarget
DB01110MiconazoleSmall Molecule22916-47-8Approved|InvestigationalTarget
DB01119DiazoxideSmall Molecule364-98-7ApprovedTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB04209DequaliniumSmall Molecule6707-58-0Approved|InvestigationalTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB09089TrimebutineSmall Molecule39133-31-8ApprovedTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 protein"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 protein"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 protein"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 protein"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 protein"25510870
D000109AcetylcholineKCNMA1 protein affects the susceptibility to Acetylcholine22226998
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KCNMA1 mRNA19770486
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [JAK2 protein results in increased activity of KCNMA1 protein mutant form]"24696148
D000638AmiodaroneAmiodarone results in increased expression of KCNMA1 mRNA19774075
D001151ArsenicArsenic affects the methylation of KCNMA1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of KCNMA1 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCNMA1 mRNA20064835|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KCNMA1 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of KCNMA1 mRNA20660070
D004958EstradiolEstradiol results in increased activity of KCNMA1 protein18068743
D004958Estradioliberiotoxin inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]18068743
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]18068743
D004958EstradiolTetraethylammonium inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]18068743
D004958EstradiolEstradiol results in decreased expression of KCNMA1 mRNA16102753
D004958EstradiolEstradiol results in decreased expression of KCNMA1 mRNA alternative form16102753
D004958EstradiolEstradiol results in decreased expression of KCNMA1 protein16102753
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA]16102753
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA alternative form]16102753
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 protein]16102753
C044887beta-methylcholinebeta-methylcholine affects the expression of KCNMA1 mRNA21179406
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of KCNMA1 mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of KCNMA1 mRNA24534842
C006780bisphenol Abisphenol A results in decreased expression of KCNMA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KCNMA1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KCNMA1 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of KCNMA1 promoter22457795
D002118CalciumKCNMA1 mRNA alternative form results in increased susceptibility to Calcium28090300
D002118Calcium[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium22123969
D002118CalciumLithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]22123969
D002118CalciumKCNMA1 mRNA alternative form results in increased susceptibility to Calcium28090300
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KCNMA1 mRNA16644059|1833908
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KCNMA1 protein17229879|1833908
D002586CesiumCesium affects the activity of KCNMA1 protein16636204
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of KCNMA1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of KCNMA1 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of KCNMA1 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of KCNMA1 mRNA23914054
D013759DronabinolDronabinol results in increased expression of KCNMA1 mRNA17578508
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of KCNMA1 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA27605626
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein27605626
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 mRNA]15088113
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 protein]15088113
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KCNMA1 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of KCNMA1 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of KCNMA1 mRNA19561079|2739243
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of KCNMA1 mRNA]27392435
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of KCNMA1 mRNA21858171
D004041Dietary FatsDietary Fats results in increased expression of KCNMA1 mRNA18042831|2501614
D004041Dietary FatsKCNMA1 gene mutant form inhibits the reaction [Dietary Fats results in increased secretion of INS1 protein]27605626
D004041Dietary FatsKCNMA1 gene mutant form results in decreased susceptibility to Dietary Fats27605626
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of KCNMA1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of KCNMA1 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of KCNMA1 mRNA20920545
C043090estradiol-bovine serum albuminestradiol-bovine serum albumin results in increased activity of KCNMA1 protein18068743
C043090estradiol-bovine serum albuminiberiotoxin inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]18068743
C043090estradiol-bovine serum albuminTetraethylammonium inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]18068743
D000431EthanolEthanol results in increased activity of KCNMA1 protein16626657
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of KCNMA1 mRNA17557909
C024565ethylene dichlorideethylene dichloride results in increased expression of KCNMA1 mRNA28189721
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA]16102753
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA alternative form]16102753
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 protein]16102753
D005947GlucoseGlucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]21413024
D005947GlucoseGlucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]21413024
D005947GlucoseNS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]21413024
D005947GlucoseNS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]21413024
D005947GlucoseTamoxifen inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]21413024
D005947GlucoseTamoxifen inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]21413024
D005947GlucoseTetraethylammonium promotes the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]21413024
D006861Hydrogen PeroxideKCNMA1 mRNA affects the susceptibility to Hydrogen Peroxide19247476
C064719iberiotoxiniberiotoxin inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]18068743
C064719iberiotoxiniberiotoxin inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]18068743
C064719iberiotoxiniberiotoxin results in decreased activity of KCNMA1 protein20050851
C492448ICG 001ICG 001 results in increased expression of KCNMA1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of KCNMA1 mRNA28628672
D007213Indomethacin[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA27605626
D007213Indomethacin[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein27605626
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of KCNMA1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA27605626
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein27605626
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of KCNMA1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of KCNMA1 mRNA]27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KCNMA1 mRNA23430699
D008095Lithocholic AcidKCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid28090300
D008095Lithocholic Acid[KCNMB1 protein co-treated with KCNMA1 protein] results in increased susceptibility to Lithocholic Acid22123969
D008095Lithocholic AcidLithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]22123969
D008095Lithocholic AcidLithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]22123969
D008095Lithocholic AcidKCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid28090300
D008095Lithocholic AcidKCNMA1 protein results in increased susceptibility to Lithocholic Acid18242174
D008095Lithocholic AcidLithocholic Acid analog results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]18650555
D008095Lithocholic AcidLithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]18650555
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of KCNMA1 mRNA22563483
D008727MethotrexateMethotrexate results in increased expression of KCNMA1 mRNA24449571
D008731MethoxychlorMethoxychlor results in increased methylation of KCNMA1 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KCNMA1 mRNA23103053
D015735MifepristoneMifepristone results in decreased expression of KCNMA1 mRNA25972201
C523799MRK 003KCNMA1 results in decreased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in decreased expression of KCNMA1 mRNA25102026
D009532NickelNickel affects the expression of KCNMA1 mRNA14575637
D009532NickelNickel results in decreased expression of KCNMA1 mRNA24768652|2558310
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of KCNMA1 mRNA]14575637
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 mRNA]15088113
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 protein]15088113
C007350nitrofennitrofen results in decreased expression of KCNMA1 mRNA15088113
C007350nitrofennitrofen results in decreased expression of KCNMA1 protein15088113
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KCNMA1 mRNA27935865
D009638NorepinephrineKCNMA1 protein affects the susceptibility to Norepinephrine22226998
C086491NS 1619NS 1619 binds to and results in increased activity of KCNMA1 protein21413024
C086491NS 1619NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]21413024
C086491NS 1619NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]21413024
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of KCNMA1 mRNA24888373
D010100OxygenKCNMA1 mRNA alternative form results in decreased susceptibility to Oxygen deficiency28090300
D010100OxygenOxygen deficiency results in increased expression of KCNMA1 mRNA alternative form28090300
D010100OxygenOxygen deficiency results in increased expression of KCNMA1 protein alternative form28090300
D017239PaclitaxelKCNMA1 protein affects the susceptibility to Paclitaxel16217747
D000073878Palm OilPalm Oil results in increased expression of KCNMA1 mRNA18042831
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of KCNMA1 mRNA22563483
D010269ParaquatParaquat results in increased expression of KCNMA1 mRNA22563483
C048220paxillineKCNMA1 protein affects the susceptibility to paxilline22226998
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 mRNA"25510870
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNMA1 protein"25510870
C046012pentanalpentanal results in increased expression of KCNMA1 mRNA26079696
D010479PergolidePergolide results in decreased activity of KCNMA1 protein16129789
D010693PhloretinKCNMA1 mRNA affects the susceptibility to Phloretin19247476
D010862PilocarpinePilocarpine results in decreased expression of KCNMA1 mRNA18695509
C008911pimaric acidKCNMA1 mRNA affects the susceptibility to pimaric acid19247476
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of KCNMA1 mRNA21858171
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of KCNMA1 mRNA24888373
D011188PotassiumKCNMA1 protein results in increased transport of Potassium16020453
D011188PotassiumKCNMA1 protein affects the transport of Potassium22226998
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of KCNMA1 mRNA20660070
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]18068743
D011374ProgesteroneProgesterone results in decreased activity of KCNMA1 protein18068743
D011374ProgesteroneProgesterone results in increased expression of KCNMA1 mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of KCNMA1 protein21795739
D011374ProgesteroneProgesterone results in increased expression of KCNMA1 mRNA16102753
D011374ProgesteroneProgesterone results in increased expression of KCNMA1 mRNA alternative form16102753
C005556propionaldehydepropionaldehyde results in increased expression of KCNMA1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of KCNMA1 mRNA24780913
C428725pyridabenpyridaben results in increased expression of KCNMA1 mRNA22563483
C089730rosiglitazone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA27605626
C089730rosiglitazone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein27605626
D012413RubidiumRubidium affects the activity of KCNMA1 protein16636204
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KCNMA1 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of KCNMA1 gene28589171
D014284Triiodothyronine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA27605626
D014284Triiodothyronine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein27605626
D013629TamoxifenTamoxifen inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]21413024
D013629TamoxifenTamoxifen inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]21413024
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of KCNMA1 mRNA17630414
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]18068743
D019789TetraethylammoniumTetraethylammonium inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]18068743
D019789TetraethylammoniumTetraethylammonium promotes the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]21413024
D019789TetraethylammoniumTetraethylammonium results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]21413024
D013793ThalliumThallium affects the activity of KCNMA1 protein16636204
D014050TolueneToluene results in decreased activity of KCNMA1 protein16626657
D019772TopotecanKCNMA1 protein affects the susceptibility to Topotecan16217747
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of KCNMA1 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of KCNMA1 mRNA23724009
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of KCNMA1 mRNA]14575637
C012589trichostatin Atrichostatin A results in decreased expression of KCNMA1 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of KCNMA1 mRNA17292431
D014638VanadatesVanadates results in increased expression of KCNMA1 mRNA22714537
C025643vinclozolinvinclozolin affects the expression of KCNMA1 mRNA19015723
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KCNMA1 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IDA15703204  
GO:0005249voltage-gated potassium channel activity-IDA7877450  12388065  
GO:0005515protein binding-IPI10692449  15528406  15703204  18287010  20613726  22547800  
GO:0015269calcium-activated potassium channel activity-IBA21873635  
GO:0015269calcium-activated potassium channel activity-IDA7573516  7877450  11245614  17706472  18458941  
GO:0015271outward rectifier potassium channel activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0060072large conductance calcium-activated potassium channel activity-IBA21873635  
GO:0060072large conductance calcium-activated potassium channel activity-IDA7993625  
GO:0060072large conductance calcium-activated potassium channel activity-IMP15703204  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA15528406  
GO:0006813potassium ion transport-IDA7573516  7877450  11245614  12388065  17706472  18458941  
GO:0006970response to osmotic stress-IDA10840032  12388065  
GO:0030007cellular potassium ion homeostasis-IDA11245614  
GO:0034465response to carbon monoxide-IDA15528406  
GO:0034465response to carbon monoxide-IMP18180950  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0042391regulation of membrane potential-IDA7877450  7993625  
GO:0043065positive regulation of apoptotic process-IMP11245614  
GO:0045794negative regulation of cell volume-IDA12388065  
GO:0051592response to calcium ion-IDA12388065  18458941  
GO:0060073micturition-IDA11641143  
GO:0060083smooth muscle contraction involved in micturition-IDA11641143  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005901caveola-IDA15703204  
GO:0008076voltage-gated potassium channel complex-IDA7573516  7877450  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IDA7573516  7877450  
GO:0016324apical plasma membrane-IDA10840032  
GO:0045211postsynaptic membrane-IBA21873635  
KEGG ID KEGG Term
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion
hsa04972Pancreatic secretion
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-1296052Ca2+ activated K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-392154Nitric oxide stimulates guanylate cyclaseIEA
R-HSA-418346Platelet homeostasisIEA
R-HSA-418457cGMP effectsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22384067Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families. (2012)Li SMPLoS One
22511924Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. (2012)Wolen ARPLoS One
25249984The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies. (2014)Bettinger JCFront Physiol
29631575The genetics of smoking in individuals with chronic obstructive pulmonary disease. (2018 Apr 10)Obeidat MRespir Res
16340454Autosomal linkage analysis for the level of response to alcohol. (2005 Nov)Schuckit MAAlcohol Clin Exp Res
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res