Gene: ENTPD8

377841
E-NTPDase|GLSR2492|NTPDase-8|UNQ2492
ectonucleoside triphosphate diphosphohydrolase 8
protein-coding
9q34.3
Ensembl:ENSG00000188833 MIM:616748 Vega:OTTHUMG00000131831 UniprotKB:Q5MY95
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.521e-1 (AD)  3.912e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENPP30.471
ACCS0.44
WDR900.44
MST10.438
STPG20.436
SZT20.435
CHTF180.433
LY6G5B0.43
FSIP20.428
SAPCD10.423

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F16-0.255
CHRNA5-0.207
PLA2G5-0.201
C7orf61-0.193
CHAC2-0.193
HIST1H4B-0.19
TSACC-0.187
HIST1H1T-0.187
BTLA-0.182
AGRP-0.181

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ENTPD8 mRNA"25614096
D000082AcetaminophenAcetaminophen affects the expression of ENTPD8 mRNA17562736
D001507BeclomethasoneBeclomethasone results in increased expression of ENTPD8 mRNA23656298
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ENTPD8 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ENTPD8 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ENTPD8 mRNA25181051
D016572CyclosporineCyclosporine results in decreased expression of ENTPD8 mRNA19770486
C000944dicrotophosdicrotophos results in decreased expression of ENTPD8 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of ENTPD8 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ENTPD8 mRNA21592394
C039281furanfuran results in increased methylation of ENTPD8 gene22079235
D017313FenretinideFenretinide results in increased expression of ENTPD8 mRNA28973697
C008261lead acetatelead acetate results in increased expression of ENTPD8 mRNA20542052
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ENTPD8 mRNA"24972896
D008727MethotrexateMethotrexate affects the expression of ENTPD8 mRNA18502557
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ENTPD8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ENTPD8 mRNA"25554681
C016030pantogabpantogab results in decreased expression of ENTPD8 mRNA17379144
C006253pirinixic acidpirinixic acid results in decreased expression of ENTPD8 mRNA20813756|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of ENTPD8 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of ENTPD8 mRNA22238285
C089730rosiglitazonerosiglitazone results in decreased expression of ENTPD8 mRNA25572481
D012524SarinSarin results in decreased expression of ENTPD8 mRNA19522546
C016104sodium bichromatesodium bichromate results in decreased expression of ENTPD8 mRNA24612858
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ENTPD8 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ENTPD8 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of ENTPD8 mRNA21073676
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ENTPD8 mRNA19770486
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ENTPD8 mRNA28973375
D013853ThioacetamideThioacetamide results in decreased expression of ENTPD8 mRNA23411599
D014635Valproic AcidValproic Acid results in increased methylation of ENTPD8 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0017110nucleoside-diphosphatase activity-EXP16752921  17095758  
GO:0017111nucleoside-triphosphatase activity-EXP17095758  
GO:0046872metal ion binding-IEA-  
GO:0102485dATP phosphohydrolase activity-IEA-  
GO:0102486dCTP phosphohydrolase activity-IEA-  
GO:0102487dUTP phosphohydrolase activity-IEA-  
GO:0102488dTTP phosphohydrolase activity-IEA-  
GO:0102489GTP phosphohydrolase activity-IEA-  
GO:01024908-oxo-dGTP phosphohydrolase activity-IEA-  
GO:0102491dGTP phosphohydrolase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009124nucleoside monophosphate biosynthetic process-IEA-  
GO:0009133nucleoside diphosphate biosynthetic process-IEA-  
GO:0034656nucleobase-containing small molecule catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-8850843Phosphate bond hydrolysis by NTPDase proteinsTAS
R-HSA-8956319Nucleobase catabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17727719Effect of active smoking on the human bronchial epithelium transcriptome. (2007 Aug 29)Chari RBMC Genomics