Gene: KCNN1

3780
KCa2.1|SK1|SKCA1|hSK1
potassium calcium-activated channel subfamily N member 1
protein-coding
19p13.11
Ensembl:ENSG00000105642 MIM:602982 Vega:OTTHUMG00000183482 UniprotKB:Q92952
NG_029893.1
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.162e-1 (AD)  3.464e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
JPH30.954
MAP3K100.944
PDZD40.936
PANX20.934
DGKZ0.932
BTBD20.929
FBXL190.922
BRSK10.92
AGAP30.918
SCRT10.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.599
OR4F29-0.554
C1orf87-0.497
C9orf135-0.468
IGF2BP2-0.462
TFPI2-0.46
SELL-0.454
GBP2-0.445
CHI3L2-0.442
BAZ1A-0.44

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01110MiconazoleSmall Molecule22916-47-8Approved|InvestigationalTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB09089TrimebutineSmall Molecule39133-31-8ApprovedTarget
ID Drug Name Action PubMed
C1103496,10-diaza-3(1,3),8(1,4)dibenzena-1,5(1,4)diquinolinacyclodecaphane"6,10-diaza-3(1,3),8(1,4)dibenzena-1,5(1,4)diquinolinacyclodecaphane results in decreased activity of KCNN1 protein"10696100
D000447AldehydesAldehydes results in increased expression of KCNN1 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of KCNN1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNN1 mRNA16483693
D001030ApaminApamin results in decreased activity of KCNN1 protein10696100
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCNN1 mRNA15034205
C017069bicuculline methiodidebicuculline methiodide results in decreased activity of KCNN1 protein10696100
C006780bisphenol Abisphenol A results in decreased expression of KCNN1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of KCNN1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of KCNN1 mRNA12160620
D002220CarbamazepineCarbamazepine affects the expression of KCNN1 mRNA25979313
D003868DequaliniumDequalinium results in decreased activity of KCNN1 protein10696100
C056574leiurotoxin Ileiurotoxin I results in decreased activity of KCNN1 protein10696100
C046012pentanalpentanal results in increased expression of KCNN1 mRNA26079696
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of KCNN1 mRNA28973697
D010575PesticidesPesticides results in decreased methylation of KCNN1 gene28396702
D010862PilocarpinePilocarpine results in decreased expression of KCNN1 protein20553876
D010936Plant ExtractsPlant Extracts results in decreased expression of KCNN1 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of KCNN1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of KCNN1 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of KCNN1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KCNN1 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of KCNN1 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCNN1 mRNA21570461
D013793ThalliumKCNN1 protein affects the transport of Thallium18774291|1882435
D014212TretinoinTretinoin results in decreased expression of KCNN1 mRNA23724009
D014403TubocurarineTubocurarine results in decreased activity of KCNN1 protein10696100
D014635Valproic AcidValproic Acid affects the expression of KCNN1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of KCNN1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of KCNN1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KCNN1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005516calmodulin binding-IBA21873635  
GO:0015269calcium-activated potassium channel activity-TAS8781233  
GO:0016286small conductance calcium-activated potassium channel activity-IBA21873635  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-TAS8781233  
GO:0007268chemical synaptic transmission-TAS8781233  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0008076voltage-gated potassium channel complex-TAS8781233  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296052Ca2+ activated K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics
25662840KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. (2015 Jul)Padula AENeuropsychopharmacology