Gene: KCNN2

3781
KCa2.2|SK2|SKCA2|SKCa 2|hSK2
potassium calcium-activated channel subfamily N member 2
protein-coding
5q22.3
Ensembl:ENSG00000080709 MIM:605879 Vega:OTTHUMG00000128836 UniprotKB:Q9H2S1
NC_000005.10
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.511e-2 (AD)  1.482e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2416371chr5:114440173 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4705665chr5:114407956 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIA40.902
CBLN20.899
CDH220.896
CACNG30.886
LRRTM40.886
KIAA1549L0.885
DPP60.885
KCTD10.885
COL26A10.883
LRRC40.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.563
WWTR1-0.556
FAM114A1-0.545
KIAA0040-0.539
YES1-0.538
REST-0.538
TFPI2-0.537
SNHG18-0.534
SEPT10-0.532
SELL-0.531

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01110MiconazoleSmall Molecule22916-47-8Approved|InvestigationalTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB09089TrimebutineSmall Molecule39133-31-8ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of KCNN2 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KCNN2 mRNA"19114083
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of KCNN2 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNN2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of KCNN2 mRNA"19561079
C1103496,10-diaza-3(1,3),8(1,4)dibenzena-1,5(1,4)diquinolinacyclodecaphane"6,10-diaza-3(1,3),8(1,4)dibenzena-1,5(1,4)diquinolinacyclodecaphane results in decreased activity of KCNN2 protein"10696100
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNN2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of KCNN2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KCNN2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCNN2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KCNN2 mRNA19770486
D000639AmitriptylineAmitriptyline results in decreased activity of KCNN2 protein10915830
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNN2 mRNA16483693
D001030ApaminApamin results in decreased activity of KCNN2 protein15868189
D001030Apamin"Apamin inhibits the reaction [[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein] which results in increased import of Thallium]"17486140
D001030ApaminApamin results in decreased activity of KCNN2 protein10991935
D001030ApaminApamin results in decreased activity of KCNN2 protein10696100
D001030ApaminApamin results in decreased activity of KCNN2 protein9287325
C006632arsenic trioxidearsenic trioxide results in decreased expression of KCNN2 mRNA26705709
C015001arsenitearsenite results in increased methylation of KCNN2 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCNN2 mRNA21802500
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of KCNN2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KCNN2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of KCNN2 mRNA"20382639
C017069bicuculline methiodidebicuculline methiodide results in decreased activity of KCNN2 protein10696100
C015712bisdequaliniumbisdequalinium results in decreased activity of KCNN2 protein10915830
C006780bisphenol Abisphenol A results in increased expression of KCNN2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of KCNN2 mRNA24586524
C006780bisphenol Abisphenol A results in increased expression of KCNN2 mRNA28079927
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNN2 promoter23359474
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of KCNN2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of KCNN2 mRNA25181051
D002118CalciumCalcium results in increased activity of KCNN2 protein17486140
D002118Calcium"cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine promotes the reaction [Calcium results in increased activity of KCNN2 protein]"17486140
D002220CarbamazepineCarbamazepine results in decreased activity of KCNN2 protein10915830
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of KCNN2 mRNA27339419
D002746ChlorpromazineChlorpromazine results in decreased activity of KCNN2 protein10915830
D002922CiguatoxinsCiguatoxins affects the expression of KCNN2 mRNA18353800
D002994ClofibrateClofibrate affects the expression of KCNN2 mRNA23811191
D002995Clofibric Acid[Clofibric Acid co-treated with Diethylnitrosamine] results in decreased expression of KCNN2 mRNA15833021
D002995Clofibric AcidClofibric Acid results in decreased expression of KCNN2 mRNA15833021
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"Apamin inhibits the reaction [[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein] which results in increased import of Thallium]"17486140
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine promotes the reaction [Calcium results in increased activity of KCNN2 protein]"17486140
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein"17486140
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein] which results in increased import of Thallium"17486140
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein"17486140
D003533CyproheptadineCyproheptadine results in decreased activity of KCNN2 protein10915830
D003561CytarabineCytarabine results in decreased expression of KCNN2 mRNA21198554
D003703DemecolcineDemecolcine results in increased expression of KCNN2 mRNA23649840
D003868DequaliniumDequalinium results in decreased activity of KCNN2 protein10696100
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNN2 promoter23359474
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of KCNN2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of KCNN2 mRNA19467301
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNN2 promoter23359474
D004052Diethylnitrosamine[Clofibric Acid co-treated with Diethylnitrosamine] results in decreased expression of KCNN2 mRNA15833021
D002117CalcitriolCalcitriol results in increased expression of KCNN2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of KCNN2 mRNA21592394
D004317DoxorubicinDoxorubicin results in decreased expression of KCNN2 mRNA28940058
C118739entinostatentinostat results in increased expression of KCNN2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNN2 mRNA"27188386
D005419FlavonoidsFlavonoids results in decreased expression of KCNN2 mRNA18035473
C039281furanfuran results in decreased expression of KCNN2 mRNA25539665
C106014geduningedunin results in decreased expression of KCNN2 mRNA17010675
D017313FenretinideFenretinide results in increased expression of KCNN2 mRNA28973697
D007099ImipramineImipramine results in decreased activity of KCNN2 protein10915830
C016517indole-3-carbinolindole-3-carbinol affects the expression of KCNN2 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KCNN2 mRNA25613284
D007657Ketone BodiesKetone Bodies results in increased expression of KCNN2 mRNA16807920
C056574leiurotoxin Ileiurotoxin I results in decreased activity of KCNN2 protein10991935
C056574leiurotoxin Ileiurotoxin I results in decreased activity of KCNN2 protein10696100
D008731MethoxychlorMethoxychlor results in increased methylation of KCNN2 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KCNN2 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KCNN2 mRNA"25554681
C016030pantogabpantogab results in decreased expression of KCNN2 mRNA17379144
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KCNN2 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of KCNN2 mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of KCNN2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of KCNN2 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of KCNN2 mRNA26272509
D010862PilocarpinePilocarpine results in decreased expression of KCNN2 mRNA20553876
D010862PilocarpinePilocarpine results in decreased expression of KCNN2 protein20553876
C006253pirinixic acidpirinixic acid results in decreased expression of KCNN2 mRNA20813756|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of KCNN2 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KCNN2 mRNA23806026
D012834SilverSilver results in decreased expression of KCNN2 mRNA27131904
C016104sodium bichromatesodium bichromate results in decreased expression of KCNN2 mRNA25993096
D013619TacrineTacrine results in decreased activity of KCNN2 protein10915830
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of KCNN2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of KCNN2 mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of KCNN2 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCNN2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KCNN2 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KCNN2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KCNN2 mRNA25613284
D013793Thallium"Apamin inhibits the reaction [[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein] which results in increased import of Thallium]"17486140
D013793Thallium"[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein] which results in increased import of Thallium"17486140
D013793ThalliumKCNN2 protein affects the transport of Thallium18774291|1882435
D013853ThioacetamideThioacetamide results in decreased expression of KCNN2 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KCNN2 mRNA18087596
D014268TrifluoperazineTrifluoperazine results in decreased activity of KCNN2 protein10915830
C050414tripterinetripterine results in decreased expression of KCNN2 mRNA17010675
D014403TubocurarineTubocurarine results in decreased activity of KCNN2 protein15868189
D014403TubocurarineTubocurarine results in decreased activity of KCNN2 protein10991935
D014403TubocurarineTubocurarine results in decreased activity of KCNN2 protein10696100
D014403TubocurarineTubocurarine results in decreased activity of KCNN2 protein9287325
D014520UrethaneUrethane results in increased expression of KCNN2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNN2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KCNN2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of KCNN2 mRNA23179753|2571616
D014750VincristineVincristine results in increased expression of KCNN2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19815520  24951510  
GO:0005516calmodulin binding-IBA21873635  
GO:0015269calcium-activated potassium channel activity-IDA17110593  
GO:0016286small conductance calcium-activated potassium channel activity-IBA21873635  
GO:0016286small conductance calcium-activated potassium channel activity-IDA24951510  
GO:0016286small conductance calcium-activated potassium channel activity-IMP19815520  
GO:0016286small conductance calcium-activated potassium channel activity-ISS19139040  
GO:0016286small conductance calcium-activated potassium channel activity-TAS10991935  
GO:0019904protein domain specific binding-IPI19815520  
GO:0042803protein homodimerization activity-IPI17110593  
GO:0051393alpha-actinin binding-IPI17110593  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-NAS10991935  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IDA17110593  24951510  
GO:0071805potassium ion transmembrane transport-ISS19139040  
GO:0098914membrane repolarization during atrial cardiac muscle cell action potential-ISS19139040  
GO:1901379regulation of potassium ion transmembrane transport-IDA17110593  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA19815520  27165696  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA19815520  
GO:0016021integral component of membrane-NAS10991935  
GO:0030018Z disc-ISS24951510  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IBA21873635  
GO:0043197dendritic spine-IBA21873635  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296052Ca2+ activated K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25662840KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. (2015 Jul)Padula AENeuropsychopharmacology