Gene: KCNN3

3782
KCa2.3|SK3|SKCA3|hSK3
potassium calcium-activated channel subfamily N member 3
protein-coding
1q21.3
Ensembl:ENSG00000143603 MIM:602983 Vega:OTTHUMG00000037260 UniprotKB:Q9UGI6
NG_016807.2
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.923e-2 (AD)  9.889e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPON10.875
TRPS10.873
ZNRF30.864
NTRK20.859
AQP40.851
ATP13A40.846
LGR40.844
BMPR1B0.842
GJA10.841
DOCK70.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SULT2B1-0.397
LGI2-0.384
PNOC-0.375
KCNS3-0.37
SCARA5-0.363
MCHR1-0.362
DUSP27-0.361
PHLDA2-0.36
CRHBP-0.355
CETP-0.353

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01110MiconazoleSmall Molecule22916-47-8Approved|InvestigationalTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB09089TrimebutineSmall Molecule39133-31-8ApprovedTarget
ID Drug Name Action PubMed
C1026351-ethyl-2-benzimidazolinone1-ethyl-2-benzimidazolinone results in increased activity of KCNN3 protein17486140
C0428883-fluoro-4-hydroxybenzoate3-fluoro-4-hydroxybenzoate analog results in decreased activity of KCNN3 protein23516517
C0428883-fluoro-4-hydroxybenzoate"naphtho(1,2-d)thiazol-2-ylamine inhibits the reaction [3-fluoro-4-hydroxybenzoate analog results in decreased activity of KCNN3 protein]"23516517
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN3 mRNA"27188386
C5073515,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one"5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one results in increased activity of KCNN3 protein"17486140
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN3 mRNA"27188386
C4933276,7-dichloro-1H-indole-2,3-dione 3-oxime"6,7-dichloro-1H-indole-2,3-dione 3-oxime promotes the reaction [Calcium results in increased activity of KCNN3 protein]"17486140
C4933276,7-dichloro-1H-indole-2,3-dione 3-oxime"6,7-dichloro-1H-indole-2,3-dione 3-oxime results in increased activity of KCNN3 protein"17486140
C4933276,7-dichloro-1H-indole-2,3-dione 3-oxime"bicuculline methobromide inhibits the reaction [6,7-dichloro-1H-indole-2,3-dione 3-oxime results in increased activity of KCNN3 protein]"17486140
D000082AcetaminophenAcetaminophen results in decreased expression of KCNN3 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KCNN3 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNN3 mRNA16483693
D001030Apamin"Apamin inhibits the reaction [[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein] which results in increased import of Thallium]"17486140
D001030ApaminApamin inhibits the reaction [[Ionomycin results in increased activity of KCNN3 protein] which results in increased import of Thallium]15634793
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to KCNN3 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KCNN3 mRNA20127859
C036615bicuculline methobromide"bicuculline methobromide inhibits the reaction [6,7-dichloro-1H-indole-2,3-dione 3-oxime results in increased activity of KCNN3 protein]"17486140
C036615bicuculline methobromidebicuculline methobromide results in decreased activity of KCNN3 protein17486140
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNN3 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of KCNN3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KCNN3 gene28505145
D002118Calcium"6,7-dichloro-1H-indole-2,3-dione 3-oxime promotes the reaction [Calcium results in increased activity of KCNN3 protein]"17486140
D002118CalciumCalcium results in increased activity of KCNN3 protein17486140
D002118Calcium"cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine promotes the reaction [Calcium results in increased activity of KCNN3 protein]"17486140
D019327Copper SulfateCopper Sulfate results in decreased expression of KCNN3 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of KCNN3 mRNA27523638
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"Apamin inhibits the reaction [[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein] which results in increased import of Thallium]"17486140
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine promotes the reaction [Calcium results in increased activity of KCNN3 protein]"17486140
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein"17486140
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein] which results in increased import of Thallium"17486140
C552889cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine"cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein"17486140
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of KCNN3 mRNA23914054
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNN3 promoter23359474
D004041Dietary FatsDietary Fats results in increased expression of KCNN3 mRNA25016146
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNN3 promoter23359474
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KCNN3 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of KCNN3 mRNA18035473
C069837fullerene C60fullerene C60 results in increased expression of KCNN3 mRNA19167457
D015759IonomycinApamin inhibits the reaction [[Ionomycin results in increased activity of KCNN3 protein] which results in increased import of Thallium]15634793
D015759IonomycinIonomycin results in increased activity of KCNN3 protein15634793
D015759Ionomycin[Ionomycin results in increased activity of KCNN3 protein] which results in increased import of Thallium15634793
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KCNN3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KCNN3 mRNA26011545
C535212naphtho(1,2-d)thiazol-2-ylamine"naphtho(1,2-d)thiazol-2-ylamine inhibits the reaction [3-fluoro-4-hydroxybenzoate analog results in decreased activity of KCNN3 protein]"23516517
C028007nickel monoxidenickel monoxide results in increased expression of KCNN3 mRNA19167457
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of KCNN3 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNN3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of KCNN3 mRNA26272509
D010862PilocarpinePilocarpine results in decreased expression of KCNN3 mRNA20553876
D010862PilocarpinePilocarpine results in decreased expression of KCNN3 protein20553876
C005556propionaldehydepropionaldehyde results in increased expression of KCNN3 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of KCNN3 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KCNN3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KCNN3 mRNA23806026
D012999SomanSoman results in increased expression of KCNN3 mRNA19281266
D013793Thallium"Apamin inhibits the reaction [[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein] which results in increased import of Thallium]"17486140
D013793Thallium"[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein] which results in increased import of Thallium"17486140
D013793ThalliumApamin inhibits the reaction [[Ionomycin results in increased activity of KCNN3 protein] which results in increased import of Thallium]15634793
D013793Thallium[Ionomycin results in increased activity of KCNN3 protein] which results in increased import of Thallium15634793
D013793ThalliumKCNN3 protein affects the transport of Thallium18774291|1882435
D014635Valproic AcidValproic Acid affects the expression of KCNN3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KCNN3 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of KCNN3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005516calmodulin binding-IBA21873635  
GO:0016286small conductance calcium-activated potassium channel activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296052Ca2+ activated K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27490364High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model. (2016 Aug)Lo CLPLoS Genet
25662840KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. (2015 Jul)Padula AENeuropsychopharmacology