Gene info: ID 3784

Gene: KCNQ1

GENE ID: 3784

Synonyms: ATFB1|ATFB3|JLNS1|KCNA8|KCNA9|KVLQT1|Kv1.9|Kv7.1|LQT|LQT1|RWS|SQT2|WRS

Description: potassium voltage-gated channel subfamily Q member 1

Gene type: protein-coding

Location: 11p15.5-p15.4

dbXrefs: Ensembl:ENSG00000053918 MIM:607542 Vega:OTTHUMG00000009900 UniprotKB:P51787

RefSeq: NG_008935.1

Retrived from: PubMed|SNP Mapped

SNPs: 4 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.289e-2 (AD) 7.819e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs231872	chr11:2765831 (GRCh38.p7)	G>A / G>C / G>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs231910	chr11:2730055 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs2283214	chr11:2729490 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)
rs12574151	chr11:2659888 (GRCh38.p7)	T>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14392746	chr11:2721207	KCNQ1	Gene body	6.288e-4	Alcohol use disorders	26763658
cg05438727	chr11:2800047	KCNQ1		2.100e-12	Smoking	27651444
cg10151367	chr11:2847642	KCNQ1		5.900e-12	Smoking	27651444
cg17333973	chr11:2847019	KCNQ1		1.900e-10	Smoking	27651444
cg06603309	chr11:2724144	KCNQ1		2.710e-14	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SYK	0.918
NCKAP1L	0.917
CD37	0.911
TBXAS1	0.905
DOCK2	0.902
IRF8	0.902
TLR6	0.901
MILR1	0.896
TLR7	0.895
HLA-DMB	0.889

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP2C2	-0.408
TMEM191C	-0.363
KRTAP5-7	-0.361
ST6GAL2	-0.359
MAGIX	-0.353
KCNIP3	-0.339
CHRNA4	-0.337
FEZF2	-0.337
WNT7A	-0.337
BDH1	-0.336

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00808	Indapamide	Small Molecule	26807-65-8	Approved	Target
DB01244	Bepridil	Small Molecule	64706-54-3	Approved\|Withdrawn	Target
DB04957	Azimilide	Small Molecule	149908-53-2	Investigational	Target
DB06089	ICA-105665	Small Molecule	-	Investigational	Target
DB11633	Isavuconazole	Small Molecule	241479-67-4	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C112297	10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone	"10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone results in decreased activity of KCNQ1 protein"	18568022
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of KCNQ1 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNQ1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNQ1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNQ1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNQ1 mRNA"	27188386
C103474	6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane	"6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane results in decreased activity of KCNQ1 protein"	20050851
C103474	6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane	"6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]"	16909339
C103474	6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane	"6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane inhibits the reaction [[KCNQ1 protein binds to KCNE3 protein] which affects the transport of Potassium]"	11527966
C103474	6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane	"6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane results in decreased activity of [KCNQ1 protein binds to KCNE3 protein]"	16055675
C117298	7,8-benzoquinoline	"7,8-benzoquinoline results in increased activity of KCNQ1 protein"	12967937
D020106	Acrylamide	Acrylamide analog results in decreased activity of KCNQ1 protein	16904708
D020106	Acrylamide	KCNE1 protein promotes the reaction [Acrylamide analog results in decreased activity of KCNQ1 protein]	16904708
D000393	Air Pollutants	KCNQ1 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]	27281273
D000638	Amiodarone	Amiodarone results in decreased activity of KCNQ1 protein	18329740
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of KCNQ1 mRNA	16483693
D000838	Anions	KCNQ1 protein affects the secretion of Anions	12967937
D001073	Aprindine	KCNQ1 gene affects the susceptibility to Aprindine	15028050
D001151	Arsenic	Arsenic affects the expression of and affects the methylation of KCNQ1	28927277
D001151	Arsenic	Arsenic affects the expression of KCNQ1 mRNA	25304211
D001151	Arsenic	Arsenic affects the methylation of KCNQ1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide affects the activity of [KCNQ1 protein co-treated with KCNE1 protein]	14691044
C015001	arsenite	arsenite results in increased methylation of KCNQ1 promoter	23974009
D001262	Atenolol	KCNQ1 gene affects the susceptibility to Atenolol	15028050
C547126	AZM551248	AZM551248 results in decreased expression of KCNQ1 mRNA	22323515
D001464	Barium	Barium results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]	16909339
C024986	barium chloride	barium chloride results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]	16909339
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of KCNQ1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KCNQ1 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of KCNQ1 mRNA	22228805
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of KCNQ1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased methylation of KCNQ1 promoter	27312807
C006780	bisphenol A	bisphenol A results in increased methylation of KCNQ1 promoter	27312807
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of KCNQ1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of KCNQ1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of KCNQ1 gene	28505145
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of KCNQ1 mRNA	22079614
D002045	Bupivacaine	Bupivacaine results in decreased activity of KCNQ1 protein	16931984
D002045	Bupivacaine	Bupivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]	16931984
D002045	Bupivacaine	KCNE1 protein inhibits the reaction [KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine]	16931984
D002045	Bupivacaine	KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine	16931984
C018475	butyraldehyde	butyraldehyde results in decreased expression of KCNQ1 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of KCNQ1 mRNA	23741332
D002712	Chlorides	[KCNQ1 protein binds to KCNE3 protein] which results in increased secretion of Chlorides	16055675
D002994	Clofibrate	Clofibrate results in increased expression of KCNQ1 mRNA	17585979
D003630	Daunorubicin	Daunorubicin results in decreased expression of KCNQ1 mRNA	26537877\|2894005
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of KCNQ1 mRNA	26924002
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of KCNQ1 mRNA	20920545
D004052	Diethylnitrosamine	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of KCNQ1 gene	23968726
D004317	Doxorubicin	Doxorubicin results in decreased expression of KCNQ1 mRNA	26537877\|2894005
C118739	entinostat	entinostat results in increased expression of KCNQ1 mRNA	27188386
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of KCNQ1 gene	16724327
C069837	fullerene C60	fullerene C60 results in increased expression of KCNQ1 mRNA	19167457
C420023	HMR 1556	HMR 1556 results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]	16909339
D007545	Isoproterenol	Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]	16909339
D007545	Isoproterenol	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]]	16909339
C113498	L 364373	L 364373 results in increased activity of [KCNQ1 protein binds to KCNE1 protein]	16945016
C061017	linopirdine	linopirdine results in decreased activity of KCNQ1 protein	18568022
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of KCNQ1 mRNA	12057914
D008619	Mepivacaine	Mepivacaine results in decreased activity of KCNQ1 protein	16931984
D008619	Mepivacaine	Mepivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]	16931984
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of KCNQ1 mRNA	24810058
D008942	Mitoxantrone	Mitoxantrone results in decreased expression of KCNQ1 mRNA	26537877\|2894005
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of KCNQ1 mRNA	26924002
D009151	Mustard Gas	Mustard Gas affects the expression of KCNQ1 mRNA	15651846
C476437	N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide	KCNE1 protein promotes the reaction [N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide results in decreased activity of KCNQ1 protein]	16904708
C476437	N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide	N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide results in decreased activity of KCNQ1 protein	16904708
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]]	16909339
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of KCNQ1 mRNA"	25620056
C031721	naphthalene	naphthalene results in increased expression of KCNQ1 mRNA	18978301
C028007	nickel monoxide	nickel monoxide results in increased expression of KCNQ1 mRNA	19167457
D052638	Particulate Matter	KCNQ1 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]	27281273
C046012	pentanal	pentanal results in increased expression of KCNQ1 mRNA	26079696
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNQ1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of KCNQ1 mRNA	26272509
D010882	Piperonyl Butoxide	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of KCNQ1 gene	23968726
D011188	Potassium	[KCNQ1 protein binds to KCNE1 protein] which affects the transport of Potassium	16909339
D011188	Potassium	"6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane inhibits the reaction [[KCNQ1 protein binds to KCNE3 protein] which affects the transport of Potassium]"	11527966
D011188	Potassium	[KCNQ1 protein binds to KCNE3 protein] which affects the transport of Potassium	11527966
D011433	Propranolol	KCNQ1 gene affects the susceptibility to Propranolol	15028050
C576869	(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide	(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide results in increased activity of KCNQ1 protein	22910039
C037663	ropivacaine	ropivacaine results in decreased activity of KCNQ1 protein	16931984
C037663	ropivacaine	ropivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]	16931984
C541923	sandostatinLAR	sandostatinLAR results in decreased expression of KCNQ1 mRNA	17210224
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of KCNQ1 mRNA	25895662
C017947	sodium arsenite	sodium arsenite affects the methylation of KCNQ1 gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of KCNQ1 mRNA	21776218
D016593	Terfenadine	KCNE1 protein inhibits the reaction [KCNQ1 protein mutant form results in increased susceptibility to Terfenadine]	16931984
D016593	Terfenadine	KCNQ1 protein mutant form results in increased susceptibility to Terfenadine	16931984
D013793	Thallium	KCNQ1 protein affects the transport of Thallium	22910039
D014212	Tretinoin	Tretinoin results in decreased expression of KCNQ1 mRNA	23724009
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of KCNQ1 mRNA	19042947
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNQ1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of KCNQ1 mRNA	26272509\|2800136
D014635	Valproic Acid	Valproic Acid results in increased methylation of KCNQ1 gene	29154799
D014639	Vanadium	Vanadium results in increased expression of KCNQ1 mRNA	15159208
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of KCNQ1 mRNA	26682919
D015032	Zinc	Zinc results in increased expression of KCNQ1 mRNA	15159208\|1707474
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of KCNQ1 mRNA	17074742

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005249	voltage-gated potassium channel activity	-	IBA	21873635
GO:0005249	voltage-gated potassium channel activity	-	IDA	8900283 17289006 24855057
GO:0005249	voltage-gated potassium channel activity	contributes_to	IDA	16002409
GO:0005251	delayed rectifier potassium channel activity	-	IBA	21873635
GO:0005251	delayed rectifier potassium channel activity	-	IDA	12522251 24184248 24269949 25037568
GO:0005251	delayed rectifier potassium channel activity	contributes_to	IDA	8900283 9354802 10400998 11299204 19646991
GO:0005515	protein binding	-	IPI	19521339 19687231 20533308 22024150 23529131
GO:0005516	calmodulin binding	-	IBA	21873635
GO:0005516	calmodulin binding	-	IDA	18165683
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	-	IDA	25037568
GO:0008157	protein phosphatase 1 binding	-	IDA	11799244
GO:0015271	outward rectifier potassium channel activity	-	IBA	21873635
GO:0015271	outward rectifier potassium channel activity	-	IDA	9312006 11101505 25705178
GO:0034236	protein kinase A catalytic subunit binding	-	IDA	11799244
GO:0034237	protein kinase A regulatory subunit binding	-	IDA	11799244
GO:0044325	ion channel binding	-	IPI	11101505 12324418 20196769 24855057 25037568
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	-	IMP	12522251
GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	-	IBA	21873635
GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	-	IMP	12522251 25786344
GO:0097110	scaffold protein binding	-	IPI	11799244 16002409 18093912
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	-	IBA	21873635
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	-	IMP	8528244

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006349	regulation of gene expression by genetic imprinting	-	IEA	-
GO:0007605	sensory perception of sound	-	TAS	9020846
GO:0008016	regulation of heart contraction	-	IC	8900283
GO:0010460	positive regulation of heart rate	-	IMP	19646991
GO:0016458	gene silencing	-	IEA	-
GO:0035690	cellular response to drug	-	IDA	9108097
GO:0048839	inner ear development	-	ISS	-
GO:0050892	intestinal absorption	-	ISS	-
GO:0060048	cardiac muscle contraction	-	IMP	8528244
GO:0060306	regulation of membrane repolarization	-	IDA	11299204
GO:0060306	regulation of membrane repolarization	-	IMP	8900283
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	-	IMP	8528244
GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	-	IMP	12522251
GO:0060452	positive regulation of cardiac muscle contraction	-	IMP	19646991
GO:0060453	regulation of gastric acid secretion	-	ISS	-
GO:0070293	renal absorption	-	ISS	-
GO:0071320	cellular response to cAMP	-	IDA	11299204 16002409
GO:0071320	cellular response to cAMP	-	IMP	18093912
GO:0071435	potassium ion export	-	IDA	8900283 10400998
GO:0071805	potassium ion transmembrane transport	-	IBA	21873635
GO:0071805	potassium ion transmembrane transport	-	IDA	9354802 11299204 16002409
GO:0071872	cellular response to epinephrine stimulus	-	TAS	11799244
GO:0072358	cardiovascular system development	-	IEA	-
GO:0086005	ventricular cardiac muscle cell action potential	-	IMP	8528244
GO:0086011	membrane repolarization during action potential	-	IDA	8900283 11299204 19646991
GO:0086013	membrane repolarization during cardiac muscle cell action potential	-	IMP	8528244
GO:0086013	membrane repolarization during cardiac muscle cell action potential	-	TAS	11299204
GO:0086014	atrial cardiac muscle cell action potential	-	IMP	12522251
GO:0086091	regulation of heart rate by cardiac conduction	-	IMP	8528244
GO:0097623	potassium ion export across plasma membrane	-	IBA	21873635
GO:0097623	potassium ion export across plasma membrane	-	IDA	17289006
GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential	-	IMP	12522251 25786344
GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	-	IMP	8528244
GO:1901381	positive regulation of potassium ion transmembrane transport	-	IDA	8900283

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	25037568
GO:0005764	lysosome	-	IDA	21957902
GO:0005769	early endosome	-	IDA	21957902
GO:0005769	early endosome	colocalizes_with	IMP	23529131
GO:0005770	late endosome	-	IDA	21957902
GO:0005783	endoplasmic reticulum	-	IDA	21228319 24855057
GO:0005783	endoplasmic reticulum	colocalizes_with	IPI	24855057
GO:0005886	plasma membrane	-	IDA	10646604 21228319 22024150 23529131 24184248 25037568 25705178
GO:0005886	plasma membrane	-	TAS	-
GO:0008076	voltage-gated potassium channel complex	-	IBA	21873635
GO:0008076	voltage-gated potassium channel complex	-	IC	8900283
GO:0008076	voltage-gated potassium channel complex	-	IDA	16002409 17289006 19646991
GO:0016021	integral component of membrane	-	IBA	21873635
GO:0016323	basolateral plasma membrane	-	IDA	21228319 21957902
GO:0030659	cytoplasmic vesicle membrane	-	IEA	-
GO:0034702	ion channel complex	-	IPI	24855057
GO:0045121	membrane raft	-	IDA	20533308 24855057

KEGG ID	KEGG Term
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion
hsa04974	Protein digestion and absorption
hsa05110	Vibrio cholerae infection

Reactome ID	Reactome Term	Evidence
R-HSA-112316	Neuronal System	TAS
R-HSA-1296071	Potassium Channels	TAS
R-HSA-1296072	Voltage gated Potassium channels	TAS
R-HSA-397014	Muscle contraction	TAS
R-HSA-5576890	Phase 3 - rapid repolarisation	TAS
R-HSA-5576891	Cardiac conduction	TAS
R-HSA-5576893	Phase 2 - plateau phase	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29520783	The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study. (2018 Mar)	Kobayashi T	J Periodontol
26927145	Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. (2016 Feb 26)	Gao K	Int J Environ Res Public Health
25516658	Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan. (2014 Dec 14)	Kuruma S	World J Gastroenterol
26540651	Association Between KCNQ1 Genetic Variants and Type 2 Diabetes in the Uyghur Population. (2015 Dec)	Ma Q	Genet Test Mol Biomarkers