Gene: KCNQ3

3786
BFNC2|EBN2|KV7.3
potassium voltage-gated channel subfamily Q member 3
protein-coding
8q24.22
Ensembl:ENSG00000184156 MIM:602232 Vega:OTTHUMG00000137472 UniprotKB:O43525
NG_008854.2
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.273e-1 (AD)  8.928e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1991718chr8:132149077 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1595411chr8:132147178 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2469518chr8:132144220 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO5A0.951
STAU20.948
NMNAT20.947
INPP4A0.945
GSK3B0.945
UNC800.945
SYNJ10.944
TRIM370.943
ARHGEF90.94
DLGAP10.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.513
FLT3LG-0.499
MYL3-0.491
HEY2-0.49
RAI14-0.478
SNHG18-0.477
RAB13-0.47
ROM1-0.467
COPZ2-0.466
OR4F5-0.456

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00586DiclofenacSmall Molecule15307-86-5ApprovedTarget
DB00939Meclofenamic acidSmall Molecule644-62-2ApprovedTarget
DB04953EzogabineSmall Molecule150812-12-7Approved|InvestigationalTarget
DB06089ICA-105665Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C11229710,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone"10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone inhibits the reaction [[KCNQ2 protein binds to KCNQ3 protein] which results in increased transport of Thallium]"20208034
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of KCNQ3 mRNA"29112739
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of KCNQ3 mRNA"27291303
D020106AcrylamideAcrylamide analog affects the activity of [KCNQ2 protein binds to KCNQ3 protein]16904708
D020106AcrylamideAcrylamide results in decreased expression of KCNQ3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCNQ3 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNQ3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of KCNQ3 mRNA24449571
D001151ArsenicArsenic affects the methylation of KCNQ3 gene25304211
D016589AstemizoleAstemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]12147327
D001280AtrazineAtrazine results in decreased expression of KCNQ3 mRNA25929836
D001562BenzimidazolesBenzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]21723881
D001562Benzimidazoles[Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium21723881
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCNQ3 mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of KCNQ3 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of KCNQ3 mRNA29097150
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of KCNQ3 mRNA16644059
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNQ3 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of KCNQ3 mRNA18353800
D003300CopperCopper deficiency results in increased expression of KCNQ3 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of KCNQ3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of KCNQ3 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of KCNQ3 mRNA23640034
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of KCNQ3 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of KCNQ3 mRNA26033743
D004997Ethinyl EstradiolESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of KCNQ3 mRNA]29112739
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KCNQ3 mRNA29112739
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCNQ3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KCNQ3 mRNA29097150
C101866ezogabineezogabine affects the activity of KCNQ3 protein26627826
C101866ezogabineKCNQ3 protein mutant form results in decreased susceptibility to ezogabine26627826
D005411Flame RetardantsFlame Retardants results in increased expression of KCNQ3 mRNA29112739
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNQ3 gene20938992
C039281furanfuran results in decreased expression of KCNQ3 mRNA25539665
D006632HistamineAstemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]12147327
D006632HistamineHistamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]12147327
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of KCNQ3 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of KCNQ3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KCNQ3 mRNA24796395
C061017linopirdinelinopirdine inhibits the reaction [[KCNQ2 protein binds to KCNQ3 protein] which results in increased transport of Thallium]20208034
C018091maduramicinmaduramicin results in decreased expression of KCNQ3 mRNA29128925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KCNQ3 gene20938992
C476437N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamideN-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide affects the activity of [KCNQ2 protein binds to KCNQ3 protein]16904708
D010936Plant ExtractsPlant Extracts results in decreased expression of KCNQ3 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of KCNQ3 mRNA16293270
D011441PropylthiouracilPropylthiouracil results in increased expression of KCNQ3 mRNA24780913
D052999QuinazolinonesQuinazolinones analog results in increased activity of KCNQ3 protein21723881
D052999QuinazolinonesQuinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]21723881
D052999Quinazolinones[Quinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium21723881
D052999QuinazolinonesQuinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ5 protein]21723881
D052999Quinazolinones[Quinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ5 protein]] which results in increased import of Thallium21723881
D052999Quinazolinones[Quinazolinones analog results in increased activity of KCNQ3 protein] which results in increased import of Thallium21723881
C016766sulforafansulforafan results in decreased expression of KCNQ3 mRNA26833863
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCNQ3 mRNA17942748
D013793Thallium[Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium21723881
D013793Thallium[KCNQ2 protein binds to KCNQ3 protein] which results in increased import of Thallium21723881
D013793ThalliumKCNQ3 protein results in increased import of Thallium21723881
D013793Thallium[KCNQ5 protein binds to KCNQ3 protein] which results in increased import of Thallium21723881
D013793Thallium[Quinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium21723881
D013793Thallium[Quinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ5 protein]] which results in increased import of Thallium21723881
D013793Thallium[Quinazolinones analog results in increased activity of KCNQ3 protein] which results in increased import of Thallium21723881
D013793Thallium"10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone inhibits the reaction [[KCNQ2 protein binds to KCNQ3 protein] which results in increased transport of Thallium]"20208034
D013793Thallium[KCNQ2 protein binds to KCNQ3 protein] which results in increased transport of Thallium20208034
D013793Thalliumlinopirdine inhibits the reaction [[KCNQ2 protein binds to KCNQ3 protein] which results in increased transport of Thallium]20208034
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KCNQ3 mRNA]"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KCNQ3 mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KCNQ3 mRNA]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KCNQ3 mRNA"29112739
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KCNQ3 mRNA]"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KCNQ3 mRNA"29112739
D014635Valproic AcidValproic Acid results in increased expression of KCNQ3 mRNA28001369
D014639VanadiumVanadium results in increased expression of KCNQ3 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KCNQ3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005249voltage-gated potassium channel activity-IBA21873635  
GO:0005249voltage-gated potassium channel activity-IDA11159685  27564677  
GO:0005251delayed rectifier potassium channel activity-IBA21873635  
GO:0005515protein binding-IPI27564677  
GO:0005516calmodulin binding-IBA21873635  
GO:0005516calmodulin binding-IDA27564677  
GO ID GO Term Qualifier Evidence PubMed
GO:0007268chemical synaptic transmission-TAS9425900  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0060081membrane hyperpolarization-IEA-  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IDA11159685  27564677  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS16525039  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA10788442  11159685  
GO:0008076voltage-gated potassium channel complex-IBA21873635  
GO:0008076voltage-gated potassium channel complex-IDA11159685  27564677  
GO:0009986cell surface-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0033268node of Ranvier-ISS16525039  
GO:0043194axon initial segment-IBA21873635  
GO:0043194axon initial segment-ISS16525039  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296072Voltage gated Potassium channelsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-445095Interaction between L1 and AnkyrinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal