Gene: KDR

3791
CD309|FLK1|VEGFR|VEGFR2
kinase insert domain receptor
protein-coding
4q12
Ensembl:ENSG00000128052 MIM:191306 Vega:OTTHUMG00000128734 UniprotKB:P35968
NG_012004.1
PubMed|SNP Mapped
OD|ND|AD
33   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.538e-1 (AD)  5.429e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2305949chr4:55114289 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXC10.784
ITGB10.763
PALMD0.756
GIMAP80.753
CAV10.75
ERG0.744
ENG0.741
BMP60.739
TGFBR20.739
CDH50.733

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRFN2-0.488
KCNG1-0.484
CDH22-0.481
KCNB2-0.476
LRTM2-0.471
ANKRD34A-0.47
KCNK4-0.469
LRFN1-0.468
LRRC73-0.465
MYADML2-0.46

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00398SorafenibSmall Molecule284461-73-0Approved|InvestigationalTarget
DB01268SunitinibSmall Molecule557795-19-4Approved|InvestigationalTarget
DB04727N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREASmall MoleculeExperimentalTarget
DB04849CediranibSmall Molecule288383-20-0InvestigationalTarget
DB04879VatalanibSmall Molecule212141-54-3InvestigationalTarget
DB05014XL999Small Molecule921206-68-0InvestigationalTarget
DB05075TG-100801Small MoleculeInvestigationalTarget
DB05146XL820Small Molecule-InvestigationalTarget
DB05198CYC116Small Molecule-InvestigationalTarget
DB05578RamucirumabBiotechDrug947687-13-0Approved|InvestigationalTarget
DB05931PegdinetanibSmall Molecule906450-24-6InvestigationalTarget
DB05984RAF-265Small Molecule927880-90-8InvestigationalTarget
DB06080ABT-869Small Molecule-InvestigationalTarget
DB06101IMC-1C11BiotechDrug-InvestigationalTarget
DB06436SemaxanibSmall Molecule194413-58-6InvestigationalTarget
DB06589PazopanibSmall Molecule444731-52-6ApprovedTarget
DB06595MidostaurinSmall Molecule120685-11-2Approved|InvestigationalTarget
DB06626AxitinibSmall Molecule319460-85-0Approved|InvestigationalTarget
DB069384-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamideSmall MoleculeExperimentalTarget
DB07183N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamideSmall MoleculeExperimentalTarget
DB07274N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamideSmall MoleculeExperimentalTarget
DB073266-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamideSmall MoleculeExperimentalTarget
DB07333N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDESmall MoleculeExperimentalTarget
DB07334N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINESmall MoleculeExperimentalTarget
DB075143-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-oneSmall MoleculeExperimentalTarget
DB075283-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-oneSmall MoleculeExperimentalTarget
DB07537N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamideSmall MoleculeExperimentalTarget
DB08042N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
DB08519N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
DB08875CabozantinibSmall Molecule849217-68-1Approved|InvestigationalTarget
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
DB08901PonatinibSmall Molecule943319-70-8Approved|InvestigationalTarget
DB09078LenvatinibSmall Molecule417716-92-8Approved|InvestigationalTarget
DB09079NintedanibSmall Molecule656247-17-5ApprovedTarget
DB12307ForetinibSmall Molecule849217-64-7InvestigationalTarget
ID Drug Name Action PubMed
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased phosphorylation of and results in decreased activity of KDR protein"15313899
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"fumonisin B1 inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased phosphorylation of and results in decreased activity of KDR protein]"15313899
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Corticosterone results in decreased expression of KDR protein]"21647420
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester results in increased expression of KDR protein"21647420
C44762116-(4-fluorophenoxy)lipoxin A416-(4-fluorophenoxy)lipoxin A4 promotes the reaction [PTPN6 protein binds to KDR protein]18193074
C44762116-(4-fluorophenoxy)lipoxin A416-(4-fluorophenoxy)lipoxin A4 promotes the reaction [VEGFA promotes the reaction [PTPN6 protein binds to KDR protein]]18193074
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of KDR protein"23284745
C5131151-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased expression of KDR protein]21769449
C5131151-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]]"21769449
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"15808785
C0467282,2'-azobis(2-amidinopropane)"2,2'-azobis(2-amidinopropane) results in decreased expression of KDR mRNA"26177723
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [troglitazone results in increased expression of KDR protein]"14593122
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]]"21769449
C0700552,3',4,4',5-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"15808785
C0294982,3-bis(3'-hydroxybenzyl)butane-1,4-diol"2,3-bis(3'-hydroxybenzyl)butane-1,4-diol inhibits the reaction [Estradiol results in increased expression of KDR protein]"17289903
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone inhibits the reaction [Estradiol results in increased expression of KDR protein]"17289903
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"15808785
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"15808785
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"15808785
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KDR mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"25510870
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid inhibits the reaction [VEGFA protein results in increased expression of KDR protein]"25447407
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of KDR mRNA"21346803
C5003442-methoxyestradiol-3,17-bis-O,O-sulfamate"2-methoxyestradiol-3,17-bis-O,O-sulfamate analog results in decreased expression of KDR protein"17426705
C5003442-methoxyestradiol-3,17-bis-O,O-sulfamate"2-methoxyestradiol-3,17-bis-O,O-sulfamate results in decreased expression of KDR protein"17426705
C0229602-oxindole2-oxindole analog results in decreased activity of KDR protein15728459
C5492413-((2,4-dimethylpyrrol-5-yl)methylidenyl)-2-indolinone"3-((2,4-dimethylpyrrol-5-yl)methylidenyl)-2-indolinone results in decreased activity of KDR protein"20171196
C0163923,3'-diindolylmethane"3,3'-diindolylmethane analog results in decreased expression of KDR protein"25794856
C0284513,4,3',4'-tetrachlorobiphenyl"[3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl] results in increased expression of KDR mRNA"15808785
C0273093,4,5,3',4',5'-hexachlorobiphenyl"[3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl] results in increased expression of KDR mRNA"15808785
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl] results in increased expression of KDR mRNA"15808785
C4824923,4,5,4'-tetramethoxystilbene"3,4,5,4'-tetramethoxystilbene inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]"23770989
C4824923,4,5,4'-tetramethoxystilbene"3,4,5,4'-tetramethoxystilbene results in decreased activity of KDR protein"23770989
C5495413-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one"3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one binds to KDR protein"23062100
C5495413-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one"3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one inhibits the reaction [Adenosine Triphosphate binds to KDR protein]"23062100
C5495413-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one"[3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one inhibits the reaction [Adenosine Triphosphate binds to KDR protein]] promotes the reaction [3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one binds to KDR protein]"23062100
C5495413-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one"3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one results in decreased activity of KDR protein"23062100
C5000673-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol binds to and results in decreased activity of KDR protein15771433
C0125873,5,6-trichloro-2-pyridinol"3,5,6-trichloro-2-pyridinol results in increased expression of KDR mRNA"23220036|2513762
C4776393-(5-methyl-2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acid"3-(5-methyl-2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acid results in decreased activity of KDR protein"12766257
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of KDR mRNA"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C5610525H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of KDR protein"21608528
C5299105-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo(2,3-b)pyridin-5-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-amine"5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo(2,3-b)pyridin-5-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-amine results in decreased activity of KDR protein"20100840
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid results in decreased expression of KDR protein"17992120
D000082AcetaminophenAcetaminophen results in decreased expression of KDR mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of KDR protein16565415
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of KDR mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KDR mRNA]17585979
D000082AcetaminophenAcetaminophen results in increased expression of KDR mRNA17431590
D000082AcetaminophenAcetaminophen results in increased expression of KDR protein17431590
D000111AcetylcysteineAcetylcysteine results in increased expression of KDR protein17992120
D000255Adenosine Triphosphate"3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one inhibits the reaction [Adenosine Triphosphate binds to KDR protein]"23062100
D000255Adenosine Triphosphate"[3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one inhibits the reaction [Adenosine Triphosphate binds to KDR protein]] promotes the reaction [3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one binds to KDR protein]"23062100
D000255Adenosine TriphosphateAdenosine Triphosphate binds to KDR protein23062100
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KDR mRNA22100608|2894338
D000638AmiodaroneAmiodarone affects the expression of KDR mRNA19483382
C030419andrographolide[andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]24814888
C030419andrographolideandrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]24814888
C030419andrographolideandrographolide results in decreased expression of KDR mRNA28651835
D000880AnthraquinonesAnthraquinones analog results in decreased activity of KDR protein27473261
C006632arsenic trioxidearsenic trioxide results in decreased expression of KDR18161919|2508804
C015001arsenitearsenite results in increased methylation of KDR promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased secretion of KDR protein"21762757
D001205Ascorbic AcidAscorbic Acid results in decreased expression of KDR mRNA21919647
D001218AspartameAspartame results in increased secretion of KDR protein20837131
D001280AtrazineAtrazine results in decreased expression of KDR mRNA25929836
C503983axitinibaxitinib results in decreased activity of KDR19652060
D001374AzacitidineAzacitidine results in increased expression of KDR mRNA18037191
D001372Aza CompoundsAza Compounds results in decreased expression of KDR mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of KDR mRNA20521778
C487081belinostatbelinostat results in increased expression of KDR mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
D001553BenzbromaroneBenzbromarone affects the expression of KDR mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KDR mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KDR mRNA21964900|2261060
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KDR mRNA22300585
D004958EstradiolEstradiol results in increased expression of KDR mRNA25982407
D004958EstradiolEstradiol results in increased expression of KDR protein25982407
D004958Estradiol[Estradiol results in increased secretion of VEGFA protein] which results in increased expression of KDR protein17289903
D004958Estradiol"2,3-bis(3'-hydroxybenzyl)butane-1,4-diol inhibits the reaction [Estradiol results in increased expression of KDR protein]"17289903
D004958Estradiol"2,3-bis(3'-hydroxybenzyl)butyrolactone inhibits the reaction [Estradiol results in increased expression of KDR protein]"17289903
D004958EstradiolEstradiol results in increased expression of KDR protein17289903
D004958EstradiolEstradiol results in increased expression of KDR protein9214597
C018465bioallethrinbioallethrin results in decreased expression of KDR21788198
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [AGT protein results in increased expression of KDR mRNA]15005273
C006780bisphenol Abisphenol A results in increased expression of KDR mRNA22045264|2598240
C006780bisphenol Abisphenol A results in increased expression of KDR protein25982407
C006780bisphenol Abisphenol A results in increased secretion of KDR protein25982407
C006780bisphenol Abisphenol A results in increased expression of KDR mRNA26063408
C006780bisphenol Abisphenol A affects the expression of KDR mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA27622962
C006780bisphenol Abisphenol A results in increased expression of KDR protein22649256
D000069286Bortezomib[Bortezomib co-treated with sorafenib] results in decreased phosphorylation of KDR protein16985072
D002104CadmiumCadmium affects the activity of KDR protein21425301
C028031cadmium acetatecadmium acetate results in decreased expression of KDR mRNA26367766
D002110CaffeineCaffeine results in decreased expression of KDR mRNA26179615
D002118CalciumTRPC6 protein promotes the reaction [[VEGFA protein results in increased activity of KDR protein] which results in increased abundance of Calcium]14551041
D002118Calcium[VEGFA protein results in increased activity of KDR protein] which results in increased abundance of Calcium14551041
D002118CalciumCalcium promotes the reaction [Corticosterone results in decreased expression of KDR protein]21647420
C031293calcium silicatecalcium silicate results in increased secretion of KDR protein21762757
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KDR mRNA23845850
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KDR protein23845850
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]23845850
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein]23845850
D004390ChlorpyrifosChlorpyrifos results in increased expression of KDR mRNA21356183
D004390ChlorpyrifosChlorpyrifos results in decreased expression of KDR mRNA20350560|2322003
D004390ChlorpyrifosChlorpyrifos results in increased expression of KDR mRNA25137620
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KDR mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDR gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of KDR mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KDR mRNA]17585979
D002994ClofibrateClofibrate affects the expression of KDR mRNA19483382
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KDR mRNA17602206
D003008CloprostenolCloprostenol results in decreased expression of KDR mRNA14991729
C018021cobaltous chloridecobaltous chloride results in decreased expression of KDR mRNA19320972
D003300CopperCopper inhibits the reaction [Phenylephrine results in increased expression of KDR protein]24903162
D003300CopperCopper results in decreased expression of KDR protein19542178
D003345Corticosterone"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Corticosterone results in decreased expression of KDR protein]"21647420
D003345CorticosteroneCalcium promotes the reaction [Corticosterone results in decreased expression of KDR protein]21647420
D003345CorticosteroneCorticosterone inhibits the reaction [KDR protein binds to NR3C1 protein]21647420
D003345CorticosteroneCorticosterone results in decreased expression of KDR protein21647420
D003345CorticosteroneMifepristone inhibits the reaction [Corticosterone results in decreased expression of KDR protein]21647420
D003345CorticosteroneNR3C1 protein promotes the reaction [Corticosterone results in decreased expression of KDR protein]21647420
D003474CurcuminCurcumin affects the expression of KDR mRNA17960570
D003474CurcuminCurcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA]19297423
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]23845850
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein]23845850
D003520CyclophosphamideCyclophosphamide results in decreased expression of KDR mRNA19701751
D003520CyclophosphamideCyclophosphamide results in decreased expression of KDR protein19701751
D003520CyclophosphamideCyclophosphamide results in increased expression of KDR mRNA18632792
D016572CyclosporineCyclosporine results in decreased expression of KDR mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of KDR mRNA12110003
D016572CyclosporineEnalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA]12110003
D016572CyclosporineLosartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA]12110003
C107676deguelindeguelin metabolite results in decreased expression of KDR protein19139008
C107676deguelindeguelin results in decreased expression of KDR protein19139008
D013759DronabinolDronabinol results in decreased phosphorylation of KDR protein15313899
C050229demethoxycurcumindemethoxycurcumin affects the expression of KDR mRNA17960570
D003907DexamethasoneDexamethasone inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]23426970
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]]23426970
D003907DexamethasoneDexamethasone results in increased expression of KDR mRNA26468166
D004026DieldrinDieldrin results in decreased expression of KDR mRNA23041725
D004041Dietary FatsCurcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA]19297423
D004041Dietary Fats[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein27097221
D004041Dietary FatsDietary Fats results in increased expression of KDR mRNA18042831|1929742
D004041Dietary FatsRosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]27097221
D004041Dietary Fatssarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]27097221
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KDR mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of KDR mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of KDR mRNA17005392
D002117CalcitriolCalcitriol results in decreased expression of KDR protein19092814
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of KDR mRNA"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KDR mRNA]"21294050
C049346diniconazolediniconazole results in decreased expression of KDR21788198
C019357dioscindioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]25111127
C010945embelinembelin results in decreased expression of KDR protein24694877
D004656EnalaprilEnalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA]12110003
C118739entinostatentinostat results in increased expression of KDR mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C118739entinostatentinostat results in decreased expression of KDR protein21041383
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of KDR protein17992120|2034692
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of KDR protein modified form20346928
D000431EthanolEthanol results in decreased expression of KDR mRNA26177723|2878986
D000431EthanolEthanol results in increased expression of KDR mRNA22198099
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of KDR mRNA17557909
D005001EthionineEthionine affects the expression of KDR mRNA19483382
C032773ethyl caffeateethyl caffeate affects the expression of KDR protein24892518
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of KDR protein28549617
C069346fascaplysinefascaplysine analog results in decreased expression of KDR protein28756150
D005472FluorouracilFluorouracil results in increased expression of KDR mRNA26272751
D005485FlutamideFlutamide results in decreased expression of KDR mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KDR mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDR gene20938992
D005632Fructose[bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA27622962
C056933fumonisin B1"fumonisin B1 inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased phosphorylation of and results in decreased activity of KDR protein]"15313899
C056933fumonisin B1fumonisin B1 inhibits the reaction [Win 55212-2 results in decreased phosphorylation of and results in decreased activity of KDR protein]15313899
D005665FurosemideFurosemide results in increased expression of KDR mRNA16526316
C093577fusaproliferinfusaproliferin results in decreased activity of KDR protein25178661
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in decreased expression of KDR mRNA]18424623
D019833GenisteinGenistein results in decreased expression of KDR mRNA21048042
D019833GenisteinGenistein results in decreased expression of KDR protein22649256
D005897GlafenineGlafenine results in decreased expression of KDR mRNA24136188
D005947Glucose[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of KDR protein19228841
D005947GlucoseGlucose results in increased expression of KDR mRNA22983702
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of KDR mRNA]22983702
C004312glycidolglycidol results in decreased expression of KDR mRNA24915197
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of KDR protein26358519
D017313FenretinideFenretinide results in increased expression of KDR mRNA28973697
D002112CalcifediolCalcifediol deficiency results in decreased expression of KDR mRNA17293106
C519562imetelstatimetelstat binds to and results in decreased activity of KDR protein21559248
C082359imidaclopridimidacloprid results in decreased expression of KDR mRNA27792329
D007211IndolesIndoles results in decreased expression of KDR mRNA20521778
D007211IndolesIndoles results in increased expression of KDR mRNA20521778
D007545IsoproterenolIsoproterenol results in decreased expression of KDR mRNA20003209
D017964ItraconazoleItraconazole analog results in decreased glycosylation of KDR protein21936514
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of KDR protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]27044328
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KDR mRNA25961927
C468270Kangen-karyuKangen-karyu affects the expression of KDR mRNA20637274
C468270Kangen-karyuKangen-karyu affects the expression of KDR protein20637274
C008261lead acetatelead acetate results in decreased expression of KDR mRNA20542052
D018021Lithium ChlorideLithium Chloride results in increased expression of KDR mRNA26272751
D019808LosartanLosartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA]12110003
C013099mancozebmancozeb results in decreased expression of KDR21788198
D008344ManebManeb results in decreased expression of KDR21788198
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of KDR mRNA18497975
D008555MelittenMelitten results in decreased expression of KDR protein23110475
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KDR mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDR gene20938992
D008731MethoxychlorMethoxychlor results in increased expression of KDR protein15503810
C042405methyl caffeatemethyl caffeate analog results in decreased expression of KDR protein25481497
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KDR mRNA"25926378
C028912methylene bis(thiocyanate)methylene bis(thiocyanate) results in decreased expression of KDR21788198
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KDR mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KDR mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of KDR mRNA24213003
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of KDR protein24213003
C043243methyl tert-butyl ethermethyl tert-butyl ether results in decreased expression of KDR mRNA21684239
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]]23426970
D015735MifepristoneMifepristone results in increased expression of KDR mRNA19439560
D015735MifepristoneMifepristone inhibits the reaction [Corticosterone results in decreased expression of KDR protein]21647420
D009151Mustard GasIL10 protein affects the reaction [Mustard Gas affects the expression of KDR mRNA]16173061
D009151Mustard GasMustard Gas results in decreased expression of KDR mRNA16173061
C452423N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased activity of KDR protein15604279|1694079
C064769N-acetylsphingosineN-acetylsphingosine results in decreased expression of KDR mRNA15741222
C064769N-acetylsphingosinesphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]15741222
C064769N-acetylsphingosineN-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein15313899
D009267NaledNaled results in decreased expression of KDR21788198
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KDR mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KDR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KDR mRNA"25554681
D009287NaphthyridinesNaphthyridines analog results in decreased activity of KDR protein16000000
D009525NiacinNiacin results in increased expression of KDR mRNA17557352
D009532NickelNickel analog results in decreased expression of KDR mRNA25144474
D009538NicotineNicotine results in increased expression of KDR protein17630920
D009853OmeprazoleOmeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]26272953
D009853OmeprazoleOmeprazole affects the expression of KDR mRNA19483382
C507134ON 01910ON 01910 results in decreased phosphorylation of KDR protein25472472
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of KDR mRNA"25137620
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of KDR mRNA"23220036
C412603orantiniborantinib results in decreased phosphorylation of and results in decreased activity of KDR protein16144927
C412603orantiniborantinib results in decreased activity of KDR protein14760097|1555134
C055122orlistatorlistat results in decreased expression of KDR protein17012255
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of KDR mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of KDR mRNA25729387
D010100OxygenKDR protein affects the reaction [Oxygen deficiency results in increased expression of HIF1A protein]23144690
D010100OxygenOxygen deficiency results in increased phosphorylation of KDR protein8537383
D010100OxygenOmeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]26272953
D010100Oxygen[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of KDR protein19228841
D010100OxygenOxygen results in decreased expression of KDR mRNA22363622|2627295
D010100OxygenOxygen results in decreased expression of KDR protein26272953
D010126OzoneOzone results in decreased expression of KDR mRNA16330353
D000073878Palm OilPalm Oil results in increased expression of KDR mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
D052638Particulate MatterParticulate Matter results in increased expression of KDR mRNA17450221
D052638Particulate MatterParticulate Matter results in decreased expression of KDR mRNA25144474
C516667pazopanibpazopanib results in decreased activity of KDR protein19956806|2061637
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"25510870
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KDR mRNA"15808785
C073402PD 123319PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]14638905
D010400Penicillin GPenicillin G results in decreased expression of KDR mRNA26272751
D010400Penicillin GPenicillin G results in increased expression of KDR mRNA25137620
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KDR mRNA19162173
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KDR21788198
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of KDR mRNA19162173
D010654Phenylbutyrates"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of KDR protein"23284745
D010656PhenylephrineCopper inhibits the reaction [Phenylephrine results in increased expression of KDR protein]24903162
D010656PhenylephrinePhenylephrine results in decreased expression of KDR mRNA18158353
D010656PhenylephrinePhenylephrine results in increased expression of KDR protein24903162
D010671Phenylurea CompoundsPhenylurea Compounds results in decreased activity of KDR protein18343900
D010672PhenytoinPhenytoin results in increased expression of KDR mRNA26272751
D010705PhosgenePhosgene affects the expression of KDR mRNA16300373
D010705PhosgenePhosgene results in decreased expression of KDR mRNA18645720
D010705PhosgenePhosgene results in decreased expression of KDR protein18645720
C068564phosphatidylbutanolKDR protein affects the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol]14704231
C014153pirimiphos methylpirimiphos methyl results in increased expression of KDR mRNA27845199
C006253pirinixic acidpirinixic acid results in decreased expression of KDR mRNA18445702|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of KDR mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of KDR mRNA19483382
C008971polymarcinepolymarcine results in decreased expression of KDR21788198
C545373ponatinibponatinib analog results in decreased activity of KDR protein21561767
C545373ponatinibponatinib results in decreased activity of KDR protein19878872
D011192Potassium DichromatePotassium Dichromate results in increased expression of KDR mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of KDR mRNA18692832
D011374ProgesteroneProgesterone affects the expression of KDR mRNA22365696
D011374ProgesteroneProgesterone affects the expression of KDR protein22365696
D011374ProgesteroneProgesterone results in increased expression of KDR mRNA20726854
D011441PropylthiouracilPropylthiouracil affects the expression of KDR mRNA19483382
C010313pseudocumenepseudocumene results in increased expression of KDR protein17337753
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the expression of KDR mRNA11744811
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of KDR mRNA17667850
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of KDR mRNA14752241
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of KDR protein14752241
C428725pyridabenpyridaben results in decreased expression of KDR21788198
D011794QuercetinQuercetin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]23094058
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KDR mRNA]"21294050
C531389quercetin 3'-sulfatequercetin 3'-sulfate promotes the reaction [VEGFA protein results in increased phosphorylation of KDR protein]16611395
C110310quercetin 4'-O-glucopyranosidequercetin 4'-O-glucopyranoside analog inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]22348123
C110310quercetin 4'-O-glucopyranosidequercetin 4'-O-glucopyranoside analog results in decreased activity of KDR protein22348123
C110310quercetin 4'-O-glucopyranosidequercetin 4'-O-glucopyranoside analog results in decreased phosphorylation of KDR protein22348123
C012526quercitrinquercitrin results in increased expression of KDR mRNA25193878
D011799QuinazolinesQuinazolines analog binds to and results in decreased activity of KDR protein16302797
C004532quinonequinone analog binds to and results in decreased activity of KDR protein16302797
C059514resveratrolresveratrol results in decreased expression of KDR mRNA20696143
C059514resveratrolresveratrol results in decreased expression of KDR protein17992120|2120994
C059514resveratrolresveratrol results in increased expression of KDR mRNA20696143
C059514resveratrolresveratrol results in increased expression of KDR protein modified form22314268
C059514resveratrol[SU 1498 results in decreased activity of KDR protein] inhibits the reaction [resveratrol results in increased secretion of MMP2 protein]22314268
C059514resveratrol[SU 1498 results in decreased activity of KDR protein] inhibits the reaction [resveratrol results in increased secretion of MMP9 protein]22314268
C059514resveratrol[SU 1498 results in decreased activity of KDR protein] which results in decreased susceptibility to resveratrol22314268
C059514resveratrol[FLT1 protein results in decreased activity of VEGFA protein] inhibits the reaction [resveratrol results in increased expression of KDR protein modified form]22314268
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of KDR mRNA]22983702
C059514resveratrolresveratrol promotes the reaction [TNFSF10 protein results in decreased expression of KDR protein]21209944
C059514resveratrolTNFSF10 protein promotes the reaction [resveratrol results in decreased expression of KDR protein]21209944
C013672riddelliineriddelliine results in increased expression of KDR protein12460743
C013672riddelliineriddelliine results in increased phosphorylation of and results in increased activity of KDR protein15384251
D000068718Rosuvastatin CalciumRosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]27097221
D012402RotenoneRotenone results in decreased expression of KDR21788198
D012439SaccharinSaccharin results in increased expression of KDR mRNA26272751
C064294sarpogrelatesarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]27097221
C116890SemaxinibSemaxinib results in decreased activity of KDR protein12649163|1267371
C116890SemaxinibSemaxinib results in decreased activity of KDR protein15788688
D012822Silicon DioxideSilicon Dioxide results in decreased expression of KDR mRNA23221170
D019821SimvastatinSimvastatin results in increased expression of KDR mRNA15572054
D019821SimvastatinSimvastatin inhibits the reaction [Streptozocin results in increased expression of KDR mRNA]20821229
D019821SimvastatinSimvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of KDR protein]20821229
D019821SimvastatinSimvastatin results in increased expression of KDR mRNA19109527
D019821SimvastatinSimvastatin results in increased expression of KDR protein19109527
C471405sorafenib[Bortezomib co-treated with sorafenib] results in decreased phosphorylation of KDR protein16985072
C471405sorafenibsorafenib results in decreased phosphorylation of KDR protein19139124
C471405sorafenibsorafenib affects the activity of KDR protein18808443
C471405sorafenibsorafenib results in decreased activity of KDR protein16940797|2061637
C060506sphingosine 1-phosphatesphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA]15741222
C060506sphingosine 1-phosphatesphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]15741222
C060506sphingosine 1-phosphatesphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA]15741222
D013311Streptozocin[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein27097221
D013311StreptozocinRosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]27097221
D013311Streptozocinsarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]27097221
D013311StreptozocinSimvastatin inhibits the reaction [Streptozocin results in increased expression of KDR mRNA]20821229
D013311StreptozocinSimvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of KDR protein]20821229
D013311StreptozocinStreptozocin results in increased expression of KDR mRNA15643138|2082122
D013311StreptozocinStreptozocin results in increased expression of KDR protein15643138
D013311StreptozocinStreptozocin results in increased phosphorylation of and results in increased expression of KDR protein20821229
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of KDR mRNA16214533
C483044SU 1498[SU 1498 results in decreased activity of KDR protein] inhibits the reaction [resveratrol results in increased secretion of MMP2 protein]22314268
C483044SU 1498[SU 1498 results in decreased activity of KDR protein] inhibits the reaction [resveratrol results in increased secretion of MMP9 protein]22314268
C483044SU 1498[SU 1498 results in decreased activity of KDR protein] which results in decreased susceptibility to resveratrol22314268
C483044SU 1498SU 1498 results in decreased activity of KDR protein15845615|1638507
C105686SU 5402SU 5402 results in decreased activity of KDR protein21517068
C473478sunitinibsunitinib results in decreased activity of KDR protein20616376
D013481SuperoxidesSuperoxides results in increased phosphorylation of KDR protein19571580
D013739TestosteroneTestosterone results in decreased expression of KDR mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KDR mRNA20106945|2615948
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KDR mRNA16962184|2637764
D013792ThalidomideSMPD2 protein promotes the reaction [Thalidomide results in decreased expression of KDR mRNA]15741222
D013792Thalidomidesphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA]15741222
D013792ThalidomideThalidomide results in decreased expression of KDR mRNA15741222
D013792Thalidomidesphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA]15741222
D013853ThioacetamideThioacetamide affects the expression of KDR mRNA19483382
D013893ThiramThiram results in increased expression of KDR mRNA20530235
D013893ThiramThiram results in decreased expression of KDR mRNA17954590
C009495titanium dioxidetitanium dioxide results in decreased expression of KDR mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KDR mRNA28111298
D014050TolueneToluene results in increased expression of KDR mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of KDR mRNA25729387
D019772TopotecanTopotecan results in increased expression of KDR mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of KDR mRNA"19682533
D014212Tretinoin"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of KDR protein"23284745
D014212TretinoinTretinoin results in decreased expression of KDR mRNA21934132
D014212TretinoinTretinoin results in increased expression of KDR mRNA17170094
D014212TretinoinTretinoin affects the expression of KDR mRNA25137620
D014212TretinoinTretinoin results in increased expression of KDR mRNA26272751
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in increased expression of KDR protein]15363585
D014241TrichloroethyleneTrichloroethylene results in increased expression of KDR mRNA15363585
C057693troglitazone"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [troglitazone results in increased expression of KDR protein]"14593122
C057693troglitazonetroglitazone results in increased expression of KDR protein14593122
C057693troglitazonetroglitazone results in decreased expression of KDR mRNA28973697
C057693troglitazonetroglitazone results in increased expression of KDR mRNA17569031
C057693troglitazone[Urethane co-treated with troglitazone] results in increased expression of KDR mRNA18465119
D014415TunicamycinTunicamycin results in decreased expression of KDR mRNA24370435
C022884undecaneundecane results in increased expression of KDR protein17337753
D014508UreaUrea analog results in decreased activity of KDR protein16000000
D014520Urethane[Urethane co-treated with troglitazone] results in increased expression of KDR mRNA18465119
D014520UrethaneUrethane results in increased expression of KDR mRNA18465119
D014635Valproic AcidValproic Acid affects the expression of KDR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KDR mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of KDR mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of KDR mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of KDR mRNA26272751
D014635Valproic AcidValproic Acid results in increased expression of KDR mRNA25137620
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]15005273
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]14638905
C404768vatalanibvatalanib results in decreased activity of KDR protein23062100
D001335Vehicle EmissionsVehicle Emissions inhibits the reaction [KDR protein binds to CDH5 protein]22507881
C025643vinclozolinvinclozolin affects the expression of KDR mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of KDR mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA"27188386
C111237vorinostatvorinostat results in increased expression of KDR mRNA26272509
C070417Win 55212-2fumonisin B1 inhibits the reaction [Win 55212-2 results in decreased phosphorylation of and results in decreased activity of KDR protein]15313899
C070417Win 55212-2Win 55212-2 results in decreased phosphorylation of and results in decreased activity of KDR protein15313899
D015032ZincZinc results in decreased expression of KDR mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of KDR mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-EXP7999104  9398617  10037737  15962004  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IDA10037737  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-TAS1417831  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005021vascular endothelial growth factor-activated receptor activity-IBA21873635  
GO:0005021vascular endothelial growth factor-activated receptor activity-IDA1417831  10022831  10102632  11387210  15215251  
GO:0005178integrin binding-IPI10022831  
GO:0005515protein binding-IPI1417831  11950700  12214271  12509223  16530705  16763549  
16966330  17222790  17293873  18377662  18662404  18936167  
18997771  19033661  20145116  20224550  20660291  21130043  
21596751  21893193  22789536  22897854  23374253  23397142  
23529610  23583373  24529377  
GO:0005524ATP binding-IEA-  
GO:0019838growth factor binding-IPI1417831  10022831  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0038085vascular endothelial growth factor binding-IBA21873635  
GO:0042802identical protein binding-IPI17293873  20080685  20660291  
GO:0051879Hsp90 protein binding-TAS19267251  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-TAS10022831  
GO:0001570vasculogenesis-ISS-  
GO:0001934positive regulation of protein phosphorylation-IDA19033661  
GO:0001938positive regulation of endothelial cell proliferation-IMP10022831  11387210  
GO:0002042cell migration involved in sprouting angiogenesis-ISS-  
GO:0003158endothelium development-ISS-  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-TAS1417831  
GO:0007275multicellular organism development-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA7929439  
GO:0008284positive regulation of cell proliferation-IMP15215251  
GO:0008360regulation of cell shape-IDA7929439  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010595positive regulation of endothelial cell migration-IMP10022831  
GO:0010629negative regulation of gene expression-IDA26879375  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA9804796  
GO:0016032viral process-IEA-  
GO:0016239positive regulation of macroautophagy-IGI23798385  
GO:0018108peptidyl-tyrosine phosphorylation-IDA10037737  10102632  
GO:0030154cell differentiation-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0030335positive regulation of cell migration-IDA7929439  
GO:0030335positive regulation of cell migration-IMP15215251  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0035162embryonic hemopoiesis-ISS-  
GO:0035584calcium-mediated signaling using intracellular calcium source-IMP15215251  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IDA10102632  11387210  19033661  23529610  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IMP15215251  
GO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway-IDA21885851  
GO:0038083peptidyl-tyrosine autophosphorylation-ISS-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-IMP15215251  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IDA11387210  
GO:0043491protein kinase B signaling-IMP24863063  
GO:0043536positive regulation of blood vessel endothelial cell migration-IMP26879375  
GO:0045766positive regulation of angiogenesis-IMP15215251  26879375  28637396  
GO:0046777protein autophosphorylation-IDA10037737  10102632  19033661  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IDA10102632  11387210  15215251  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IMP23529610  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0050927positive regulation of positive chemotaxis-IDA7929439  
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process-IDA10600473  
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process-IMP9837777  
GO:0051894positive regulation of focal adhesion assembly-IDA12820653  
GO:0051901positive regulation of mitochondrial depolarization-IGI23798385  
GO:0070371ERK1 and ERK2 cascade-IMP24863063  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP15215251  
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis-IMP18977327  
GO:0090141positive regulation of mitochondrial fission-IGI23798385  
GO:1904881cellular response to hydrogen sulfide-IDA26879375  
GO:2000352negative regulation of endothelial cell apoptotic process-IDA9804796  
GO:2001214positive regulation of vasculogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005768endosome-IDA23262137  
GO:0005769early endosome-ISS-  
GO:0005783endoplasmic reticulum-IDA23529610  
GO:0005794Golgi apparatus-IDA23262137  
GO:0005886plasma membrane-IDA23262137  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA10102632  
GO:0030054cell junction-ISS-  
GO:0043235receptor complex-IBA21873635  
GO:0045121membrane raft-IDA23262137  
GO:0097443sorting endosome-ISS-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-194138Signaling by VEGFTAS
R-HSA-194138Signaling by VEGFIEA
R-HSA-194306Neurophilin interactions with VEGF and VEGFRTAS
R-HSA-194313VEGF ligand-receptor interactionsTAS
R-HSA-195399VEGF binds to VEGFR leading to receptor dimerizationTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayIEA
R-HSA-5218921VEGFR2 mediated cell proliferationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11440984Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. (2001 Jul 6)Vasa MCirc Res
18704258Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening. (2008 Nov)Keymel SBasic Res Cardiol
18925614Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes. (2008 Dec)Wong CYMol Nutr Food Res
28956832Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. (2017 Sep 28)Sharafeldin NInt J Environ Res Public Health
19799717Increased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitis. (2009 Nov)Li XJ Clin Periodontol
19088108Influence of menstrual cycle on circulating endothelial progenitor cells. (2009 Mar)Robb AOHum Reprod
26683928Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection. (2015 Dec)Rhie AMedicine (Baltimore)
29455365Gender-differences in glycemic control and diabetes related factors in young adults with type 1 diabetes: results from the METRO study. (2018 Feb 17)Maiorino MIEndocrine
16129215History of cardiovascular disease is associated with endothelial progenitor cells in peritoneal dialysis patients. (2005 Sep)Steiner SAm J Kidney Dis
24188156Higher numbers of circulating endothelial progenitor cells in stroke patients with intracranial arterial stenosis. (2013 Nov 5)Liu ZBMC Neurol
27186328Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality. (2016)Slattery MLInt J Mol Epidemiol Genet
26072521A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival. (2015 Sep)Sharafeldin NJ Natl Cancer Inst
21029820Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery disease. (2010 Nov 1)Yue WSAm J Cardiol
20970515Similar gene expression profiles in smokers and patients with moderate COPD. (2011 Feb)Llinas LPulm Pharmacol Ther
16682255Relationship of smoking and fibrosis in patients with chronic hepatitis C. (2006 Jun)Dev AClin Gastroenterol Hepatol
18515295Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction. (2008 Jun)Muller-Ehmsen JEur Heart J
16926179Circulating endothelial progenitor cells correlate with erectile function in patients with coronary heart disease. (2006 Sep)Baumhakel MEur Heart J
17065374Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease? (2006 Nov)Taraseviciene-Stewart LProc Am Thorac Soc
23991993B-cell Lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population. (2013)Li QAsian Pac J Cancer Prev
29477262Predictive value of Type D personality for impaired endothelial function in patients with coronary artery disease. (2018 May 15)Denollet JInt J Cardiol
17615060Deficit of circulating stem--progenitor cells in opiate addiction: a pilot study. (2007 Jul 5)Reece ASSubst Abuse Treat Prev Policy
19587603Habitual physical activity is associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery disease. (2009 Aug)Luk THEur J Cardiovasc Prev Rehabil
29226690Low Levels of Endothelial Progenitor Cells and Their Association with Systemic Inflammation and Monocyte Activation in Older HIV-Infected Men. (2018 Jan)Seang SAIDS Res Hum Retroviruses
26726843Association of Genetic Polymorphisms on Vascular Endothelial Growth Factor and its Receptor Genes with Susceptibility to Coronary Heart Disease. (2016 Jan 4)Li LMed Sci Monit
24423369Difference in mobilization of progenitor cells after myocardial infarction in smoking versus non-smoking patients: insights from the BONAMI trial. (2013)Lamirault GStem Cell Res Ther
19034379Endothelial progenitor cells in adolescents: impact of overweight, age, smoking, sport and cytokines in younger age. (2009 Mar)Jung CClin Res Cardiol
24142520Endothelial progenitor cells in patients with chronic obstructive pulmonary disease. (2013 Dec)Brittan MAm J Physiol Lung Cell Mol Physiol
15924642[Expression of pulmonary vascular endothelial growth factor and vascular endothelial growth factor receptor in emphysema]. (2005 Apr)Wang YHZhonghua Nei Ke Za Zhi
23794399VEGFA, FLT1, KDR and colorectal cancer: assessment of disease risk, tumor molecular phenotype, and survival. (2014 Feb)Slattery MLMol Carcinog
17479290KDR expression is associated with the stage and cigarette smoking of the patients with lung cancer. (2007 Sep)An SJJ Cancer Res Clin Oncol
17909223Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. (2008 Jan)Tang DJ Lipid Res
18948947Somatic mutations affect key pathways in lung adenocarcinoma. (2008 Oct 23)Ding LNature
16288934Circulating endothelial progenitor cells from healthy smokers exhibit impaired functional activities. (2006 Aug)Michaud SEAtherosclerosis