Gene: KHK

3795
-
ketohexokinase
protein-coding
2p23.3
Ensembl:ENSG00000138030 MIM:614058 Vega:OTTHUMG00000097077 UniprotKB:P50053
NG_012199.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.187e-1 (AD)  2.141e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TOMM40L0.928
SLC25A40.921
ANXA60.921
MADD0.921
UBL4A0.921
FBXW90.921
C1orf2160.921
MAP2K50.92
STOML10.919
HMOX20.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.558
IL18RAP-0.552
WWTR1-0.549
CST7-0.536
EBF1-0.528
RNF135-0.524
YES1-0.518
S100A12-0.512
MTRNR2L10-0.512
CXCR2-0.511

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of KHK mRNA"21724226
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KHK mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KHK mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to KHK protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to KHK protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KHK mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of KHK mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of KHK mRNA17562736
D000255Adenosine TriphosphateKHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]19158351
C016601afimoxifeneKHK results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of KHK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KHK mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KHK gene28458013
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KHK mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KHK mRNA16483693
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to KHK protein]26598702
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [Fructose results in increased expression of KHK protein]21122807
D001280AtrazineAtrazine results in increased expression of KHK mRNA25929836
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of KHK mRNA21635667
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KHK mRNA19770486
D004958EstradiolEstradiol results in decreased expression of KHK mRNA20106945
C006780bisphenol Abisphenol A results in increased expression of KHK mRNA27685785
C006780bisphenol Abisphenol A affects the expression of KHK mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of KHK mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KHK gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of KHK mRNA26079696
C041167chromium nitratechromium nitrate results in decreased expression of KHK protein22144121
D003300CopperCopper results in decreased expression of KHK mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of KHK mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of KHK mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KHK mRNA17379624
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of KHK mRNA27392435
D002945CisplatinCisplatin results in increased expression of KHK mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of KHK mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of KHK mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of KHK mRNA"22485181
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KHK mRNA22079256
D000431EthanolEthanol results in increased expression of KHK protein26858005
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of KHK mRNA17108234
D005472FluorouracilFluorouracil results in increased expression of KHK protein15352031
D005472FluorouracilKHK protein affects the susceptibility to Fluorouracil15352031
D005632FructoseKHK protein results in increased metabolism of Fructose19108855
D005632FructoseKHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]19158351
D005632FructoseKHK protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]19158351
D005632FructoseKHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]19158351
D005632FructoseFGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]28123933
D005632FructoseFructose results in increased expression of and results in increased activity of KHK protein18395287
D005632FructoseFructose results in increased expression of KHK mRNA15066988|2812393
D005632FructoseFructose results in increased expression of KHK protein26858005
D005632FructoseAtorvastatin Calcium inhibits the reaction [Fructose results in increased expression of KHK protein]21122807
D005632FructoseFructose results in increased expression of KHK mRNA18346472
D005632FructoseFructose results in increased expression of KHK protein21122807
D005632FructoseKHK protein results in increased metabolism of Fructose16266770
D005632FructoseKHK protein results in increased phosphorylation of Fructose19158351
D005897GlafenineGlafenine results in decreased expression of KHK mRNA24136188
D017313FenretinideFenretinide results in increased expression of KHK mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KHK mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of KHK mRNA27392435
C544151jinfukangjinfukang results in increased expression of KHK mRNA27392435
C008261lead acetatelead acetate results in increased expression of KHK protein21247988
C031895lead chromatelead chromate results in decreased expression of KHK mRNA23584427
C045463leflunomideleflunomide results in decreased expression of KHK mRNA24136188
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of KHK mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KHK mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KHK mRNA"25620056
C022838nickel chloridenickel chloride results in decreased expression of KHK mRNA24612858
C012655nimesulidenimesulide results in decreased expression of KHK mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of KHK protein19716841
D010100OxygenOxygen deficiency results in decreased expression of KHK mRNA26516004
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of KHK mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of KHK mRNA19162173
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of KHK mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of KHK mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in decreased expression of KHK protein15226431
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KHK mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KHK mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of KHK protein22144121
D017382Reactive Oxygen SpeciesKHK protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species]19158351
C016104sodium bichromatesodium bichromate results in decreased expression of KHK mRNA24612858
C016104sodium bichromatesodium bichromate results in decreased expression of KHK mRNA25993096
C030192tagatoseKHK protein results in increased phosphorylation of tagatose19158351
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KHK mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KHK mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KHK mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KHK mRNA21215274|2172422
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of KHK mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KHK mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of KHK mRNA27188386
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of KHK mRNA28943392
D013893ThiramThiram results in increased expression of KHK mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of KHK mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KHK protein22595367
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KHK protein27319396
D014212TretinoinTretinoin results in decreased expression of KHK mRNA16604517
D014520UrethaneUrethane results in decreased expression of KHK mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of KHK mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KHK mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KHK mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of KHK mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of KHK mRNA17292431|1796380
D014638VanadatesVanadates results in decreased expression of KHK mRNA22714537
D014640VancomycinVancomycin results in increased expression of KHK mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of KHK mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004454ketohexokinase activity-EXP12941785  19237742  
GO:0004454ketohexokinase activity-IDA12941785  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009744response to sucrose-IEA-  
GO:0009749response to glucose-IEA-  
GO:0009750response to fructose-IEA-  
GO:0010043response to zinc ion-IEA-  
GO:0032868response to insulin-IEA-  
GO:0046835carbohydrate phosphorylation-IEA-  
GO:0061624fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00051Fructose and mannose metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-5652084Fructose metabolismTAS
R-HSA-5657562Essential fructosuriaTAS
R-HSA-5663084Diseases of carbohydrate metabolismTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-70350Fructose catabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11956673Effects of grapefruit juice and smoking on verapamil concentrations in steady state. (2002 Apr)Fuhr UEur J Clin Pharmacol
19214408Treatment of chronic CAD--do the guidelines (ESC, AHA) reflect daily practice? (2009 Feb)Tillmanns HHerz