Gene: KIF2A

3796
CDCBM3|HK2|KIF2
kinesin family member 2A
protein-coding
5q12.1
Ensembl:ENSG00000068796 MIM:602591 Vega:OTTHUMG00000097755 UniprotKB:O00139
NG_042185.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.221e-1 (AD)  8.130e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP320.907
SRP720.906
CCSER20.903
SLC39A60.895
KIDINS2200.894
WWP10.893
WDR440.889
FBXW110.887
ITCH0.885
IPO70.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.54
OR4F29-0.534
CSAG1-0.3
SOD3-0.265
ANPEP-0.265
PLA2G5-0.257
AHSP-0.256
FAM181A-0.25
C22orf31-0.25
PLIN4-0.247

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KIF2A mRNA"19114083
D000082AcetaminophenAcetaminophen affects the expression of KIF2A mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of KIF2A mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KIF2A mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of KIF2A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of KIF2A protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KIF2A mRNA22100608|2715375
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KIF2A mRNA16483693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KIF2A mRNA"19150397|2038263
C044887beta-methylcholinebeta-methylcholine affects the expression of KIF2A mRNA21179406
C006780bisphenol Abisphenol A results in decreased methylation of KIF2A promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of KIF2A mRNA25181051
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of KIF2A mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KIF2A mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of KIF2A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of KIF2A mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of KIF2A mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KIF2A mRNA21266533
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of KIF2A mRNA22129741
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of KIF2A mRNA25198161
D005557FormaldehydeFormaldehyde results in decreased expression of KIF2A mRNA20655997
C039281furanfuran results in increased expression of KIF2A mRNA26194646
D005839GentamicinsGentamicins results in increased expression of KIF2A mRNA22061828
D017313FenretinideFenretinide results in decreased expression of KIF2A mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of KIF2A mRNA20044591
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of KIF2A mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KIF2A mRNA25613284
C544151jinfukangjinfukang results in decreased expression of KIF2A mRNA27392435
C410337K 7174K 7174 results in increased expression of KIF2A mRNA24086573
D007854LeadLead affects the splicing of KIF2A mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of KIF2A mRNA"24972896
C015329lycopenelycopene results in increased expression of KIF2A mRNA16886892
D009532NickelNickel results in increased expression of KIF2A mRNA25583101
D010634PhenobarbitalPhenobarbital affects the expression of KIF2A mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of KIF2A mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in increased expression of KIF2A mRNA21061450
D011794QuercetinQuercetin results in decreased expression of KIF2A mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of KIF2A mRNA22714537
D012969Sodium FluorideSodium Fluoride results in increased expression of KIF2A protein28918527
C061133tamibarotenetamibarotene results in decreased expression of KIF2A mRNA15498508
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of KIF2A mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KIF2A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KIF2A promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KIF2A mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KIF2A mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of KIF2A mRNA23411599
D014050TolueneToluene results in decreased expression of KIF2A mRNA22166486
D014050TolueneToluene results in increased expression of KIF2A mRNA22166486
D014204Trenbolone AcetateTrenbolone Acetate results in increased expression of KIF2A mRNA25198161
D014212TretinoinTretinoin results in decreased expression of KIF2A mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of KIF2A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KIF2A mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of KIF2A mRNA29154799
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of KIF2A mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003774motor activity-TAS9177777  
GO:0003777microtubule motor activity-IBA21873635  
GO:0005515protein binding-IPI18411309  25416956  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IDA26323690  
GO:0016887ATPase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IGI26323690  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-TAS-  
GO:0007018microtubule-based movement-IBA21873635  
GO:0007018microtubule-based movement-TAS-  
GO:0007019microtubule depolymerization-TAS26323690  
GO:0007052mitotic spindle organization-IDA18411309  
GO:0007399nervous system development-IEA-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0030154cell differentiation-IEA-  
GO:0030334regulation of cell migration-IGI26323690  
GO:0051301cell division-IEA-  
GO:0090307mitotic spindle assembly-IMP15843429  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle polecolocalizes_withIDA18411309  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA26323690  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA21399614  
GO:0005814centriole-IDA23213374  
GO:0005819spindle-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005871kinesin complex-IBA21873635  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubulecolocalizes_withIDA26323690  
GO:0005876spindle microtubulecolocalizes_withIDA18411309  
GO:0016020membrane-HDA19946888  
GO:0016604nuclear body-IDA-  
GO:0097228sperm principal piece-IEA-  
GO:0120103centriolar subdistal appendage-IDA23213374  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-983189KinesinsTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29427669High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma. (2018 Feb 26)Xie TBiochem Biophys Res Commun