Gene: KIF5A

3798
ALS25|D12S1889|MY050|NEIMY|NKHC|SPG10
kinesin family member 5A
protein-coding
12q13.3
Ensembl:ENSG00000155980 MIM:602821 Vega:OTTHUMG00000170143 UniprotKB:Q12840
NG_008155.1
PubMed|SNP Mapped
5   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.191e-1 (AD)  6.228e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2600003chr12:57559461 (GRCh38.p7)A>C / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6581146chr12:57552694 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1148551chr12:57552077 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1148552chr12:57549189 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs703841chr12:57548522 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEKHM20.907
RAPGEF40.885
KIF5C0.852
MCF2L20.838
KIF1A0.816
SCRIB0.805
MT-ND40.776
MLLT60.773
MT-ND20.772
MT-ND4L0.769

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.769
OR4F5-0.759
TH-0.273
ISL1-0.262
SLC5A7-0.253
SLITRK6-0.252
HCRT-0.25
FEZF1-0.246
CFC1-0.239
LHX8-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of KIF5A mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF5A mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF5A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF5A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF5A mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF5A mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIF5A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIF5A mRNA"27188386
D000255Adenosine TriphosphateAdenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]28122263
D000255Adenosine TriphosphateCadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]24239783
D000255Adenosine TriphosphateEgtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]]24239783
D000255Adenosine TriphosphateKIF5A protein results in increased hydrolysis of Adenosine Triphosphate24239783
D001280AtrazineAtrazine results in increased expression of KIF5A mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of KIF5A mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KIF5A mRNA21871943
C006780bisphenol Abisphenol A results in decreased expression of KIF5A mRNA25181051
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]24239783
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of KIF5A protein24239783
D019256Cadmium ChlorideEgtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]]24239783
D019256Cadmium ChlorideEgtazic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of KIF5A protein]24239783
D002330CarmustineCarmustine results in decreased expression of KIF5A mRNA15980968
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF5A mRNA20938992
C029892cupric chloridecupric chloride results in decreased activity of KIF5A protein24853401
C029892cupric chlorideCysteine inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]24853401
C029892cupric chlorideDithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]24853401
C029892cupric chlorideEgtazic Acid inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]24853401
D003545CysteineCysteine inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]24853401
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNA"18606552
C000944dicrotophosdicrotophos results in increased expression of KIF5A mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of KIF5A mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of KIF5A mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF5A mRNA]17854601
D004229DithiothreitolDithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]24853401
C067311docetaxelKIF5A protein results in decreased susceptibility to docetaxel21479552
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]]24239783
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of KIF5A protein]24239783
D004533Egtazic AcidEgtazic Acid inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]24853401
C540355fenamidonefenamidone results in decreased expression of KIF5A mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF5A mRNA20938992
D005839GentamicinsGentamicins results in decreased expression of KIF5A mRNA22061828
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNA"18606552
C412815GW 4064GW 4064 results in increased expression of KIF5A mRNA26655953
C008261lead acetatelead acetate results in increased expression of KIF5A mRNA22609695
D018021Lithium ChlorideLithium Chloride results in decreased expression of KIF5A mRNA23527032
D015636Magnesium ChlorideMagnesium Chloride affects the reaction [zinc chloride results in decreased activity of KIF5A protein]28122263
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF5A mRNA20938992
D008731MethoxychlorMethoxychlor results in increased methylation of KIF5A gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KIF5A mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KIF5A mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF5A mRNA"15329391
C523184mocetinostatmocetinostat results in increased expression of KIF5A mRNA27255383
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF5A mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIF5A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of KIF5A mRNA26272509
D012402RotenoneRotenone results in increased expression of KIF5A mRNA23263842
C009277sodium arsenatesodium arsenate results in increased expression of KIF5A mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KIF5A mRNA27913140
C012589trichostatin Atrichostatin A results in decreased expression of KIF5A mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of KIF5A mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KIF5A mRNA"26179874
D014520UrethaneUrethane results in increased expression of KIF5A mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of KIF5A mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KIF5A gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of KIF5A mRNA25423262
C025643vinclozolinvinclozolin affects the expression of KIF5A mRNA19015723
C016837zinc chlorideAdenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]28122263
C016837zinc chlorideMagnesium Chloride affects the reaction [zinc chloride results in decreased activity of KIF5A protein]28122263
C016837zinc chloridezinc chloride results in decreased activity of KIF5A protein28122263

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003774motor activity-TAS7514426  
GO:0003777microtubule motor activity-IBA21873635  
GO:0005515protein binding-IPI20386726  22705394  24161670  25898167  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IEA-  
GO:0008574ATP-dependent microtubule motor activity, plus-end-directed-IBA21873635  
GO:0016887ATPase activity-IBA21873635  
GO:0019894kinesin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-TAS-  
GO:0007018microtubule-based movement-IBA21873635  
GO:0007018microtubule-based movement-TAS-  
GO:0007268chemical synaptic transmission-TAS7514426  
GO:0007411axon guidance-IBA21873635  
GO:0016192vesicle-mediated transport-ISS-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0030705cytoskeleton-dependent intracellular transport-IBA21873635  
GO:0048489synaptic vesicle transport-IBA21873635  
GO:0098971anterograde dendritic transport of neurotransmitter receptor complex-IBA21873635  
GO:0098971anterograde dendritic transport of neurotransmitter receptor complex-IEA-  
GO:1990049retrograde neuronal dense core vesicle transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005871kinesin complex-IBA21873635  
GO:0005871kinesin complex-TAS7514426  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubule-IEA-  
GO:0016020membrane-HDA19946888  
GO:0032839dendrite cytoplasm-IEA-  
GO:0035253ciliary rootlet-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5625970RHO GTPases activate KTN1TAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-983189KinesinsTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis