Gene: KIF5B

3799
HEL-S-61|KINH|KNS|KNS1|UKHC
kinesin family member 5B
protein-coding
10p11.22
Ensembl:ENSG00000170759 MIM:602809 Vega:OTTHUMG00000017913 UniprotKB:P33176
NC_000010.11
PubMed
0   ANCO-SNPs
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.091e-1 (AD)  1.210e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL50.921
NEK70.917
ZNF6640.913
ANKRD400.905
ZCCHC240.899
HIPK20.895
MAP4K40.894
WNK10.893
FCHSD20.893
MAP40.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.546
OR4F5-0.476
ADRA1D-0.466
FBLN7-0.446
RTP1-0.429
ABCC12-0.429
PNPLA5-0.428
CDH22-0.425
HUNK-0.424
FFAR4-0.422

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of KIF5B mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of KIF5B protein"21673325
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KIF5B mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of KIF5B mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of KIF5B mRNA"21346803
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of KIF5B mRNA20829426
D000082AcetaminophenAcetaminophen affects the expression of KIF5B mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KIF5B mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KIF5B mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of KIF5B mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of KIF5B mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KIF5B mRNA24982889
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KIF5B mRNA25270620|2733941
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of KIF5B mRNA15467011
D003300CopperCopper results in decreased expression of KIF5B mRNA17205981
D003300CopperCopper results in increased expression of KIF5B mRNA16629173
D019327Copper SulfateCopper Sulfate results in increased expression of KIF5B mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of KIF5B protein26984711
D016572CyclosporineCyclosporine results in increased expression of KIF5B mRNA20106945
D016572CyclosporineCyclosporine results in increased methylation of KIF5B promoter27989131
D016572CyclosporineCyclosporine results in decreased expression of KIF5B mRNA19770486
C000944dicrotophosdicrotophos results in decreased expression of KIF5B mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of KIF5B mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of KIF5B mRNA]19030233
D004317DoxorubicinDoxorubicin results in increased oxidation of KIF5B protein28818578
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KIF5B mRNA17942748
D005485FlutamideFlutamide results in increased expression of KIF5B mRNA24136188
D005947GlucoseGlucose results in decreased expression of KIF5B protein23776493
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of KIF5B mRNA22634610
D017313FenretinideFenretinide results in decreased expression of KIF5B mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of KIF5B mRNA19376150
C544151jinfukangjinfukang results in decreased expression of KIF5B mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of KIF5B mRNA21641980
D008731MethoxychlorMethoxychlor affects the expression of KIF5B mRNA20829426
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to KIF5B protein]17220478
C523184mocetinostatmocetinostat results in decreased expression of KIF5B mRNA27255383
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KIF5B mRNA"25620056
D009532NickelNickel results in increased expression of KIF5B mRNA24768652|2558310
C018620oleoresinsoleoresins results in decreased expression of KIF5B mRNA20008804
D010416PentachlorophenolPentachlorophenol results in increased expression of KIF5B mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KIF5B mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of KIF5B mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of KIF5B mRNA23091169
D010656PhenylephrinePhenylephrine results in decreased expression of KIF5B mRNA18158353
D010936Plant ExtractsPlant Extracts results in increased expression of KIF5B mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of KIF5B mRNA23370395
C045950propiconazolepropiconazole results in decreased expression of KIF5B mRNA19363144|2127805
D011748PyrogallolPyrogallol results in increased expression of KIF5B mRNA20362636
D011748PyrogallolSilymarin inhibits the reaction [Pyrogallol results in increased expression of KIF5B mRNA]20362636
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of KIF5B mRNA]19030233
D012838SilymarinSilymarin inhibits the reaction [Pyrogallol results in increased expression of KIF5B mRNA]20362636
C009277sodium arsenatesodium arsenate results in increased expression of KIF5B mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of KIF5B mRNA21641980
D013629TamoxifenTamoxifen affects the expression of KIF5B mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KIF5B mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KIF5B mRNA19465110
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KIF5B mRNA18087596
D014635Valproic AcidValproic Acid affects the expression of KIF5B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KIF5B mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KIF5B gene25560391
C025643vinclozolinvinclozolin affects the expression of KIF5B mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of KIF5B mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of KIF5B mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IBA21873635  
GO:0003777microtubule motor activity-IDA28426968  
GO:0003777microtubule motor activity-ISS-  
GO:0005515protein binding-IPI15161933  15324660  17353931  19164528  20562859  21915095  
25855459  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IDA28426968  
GO:0008017microtubule binding-ISS-  
GO:0008432JUN kinase binding-IEA-  
GO:0016887ATPase activity-IBA21873635  
GO:0042802identical protein binding-IPI17013387  18004302  
GO:0045296cadherin binding-HDA25468996  
GO:0099609microtubule lateral binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IBA21873635  
GO:0007018microtubule-based movement-TAS7514426  
GO:0007028cytoplasm organization-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0031340positive regulation of vesicle fusion-IEA-  
GO:0032230positive regulation of synaptic transmission, GABAergic-IEA-  
GO:0035617stress granule disassembly-ISS-  
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-IEA-  
GO:0042391regulation of membrane potential-IDA19675065  
GO:0043268positive regulation of potassium ion transport-IDA19675065  
GO:0047496vesicle transport along microtubule-IDA28426968  
GO:0047496vesicle transport along microtubule-ISS-  
GO:0051642centrosome localization-IMP20386726  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:0072383plus-end-directed vesicle transport along microtubule-IEA-  
GO:0090316positive regulation of intracellular protein transport-IEA-  
GO:1903078positive regulation of protein localization to plasma membrane-IDA19675065  
GO:1905152positive regulation of voltage-gated sodium channel activity-IEA-  
GO:1990048anterograde neuronal dense core vesicle transport-ISS-  
GO:1990049retrograde neuronal dense core vesicle transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005815microtubule organizing center-IDA-  
GO:0005829cytosol-IDA-  
GO:0005871kinesin complex-IBA21873635  
GO:0005871kinesin complex-TAS1607388  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubule-IEA-  
GO:0016020membrane-HDA19946888  
GO:0031982vesicle-IDA20682791  
GO:0035253ciliary rootlet-IEA-  
GO:0044295axonal growth cone-IEA-  
GO:0045335phagocytic vesicle-IEA-  
GO:0048471perinuclear region of cytoplasm-ISS-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5625970RHO GTPases activate KTN1TAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-983189KinesinsTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23150706RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. (2012 Dec 10)Wang RJ Clin Oncol
25773866Clinical and prognostic implications of RET rearrangements in metastatic lung adenocarcinoma patients with malignant pleural effusion. (2015 May)Tsai THLung Cancer
23877438CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (2013 Oct)Matsuura SOncol Rep
29128428Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer. (2018 Jan)Ferrara RJ Thorac Oncol
23342255RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer. (2012 Aug)Sasaki HCancer Med
24504365RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis. (2014 Mar 18)Tsuta KBr J Cancer
25567908Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches. (2015 Aug 15)Drilon AClin Cancer Res
23378251KIF5B-RET fusions in Chinese patients with non-small cell lung cancer. (2013 Apr 15)Cai WCancer
25180059Detecting ALK, ROS1 and RET Fusion Genes in Cell Block Samples. (2014 Jun)Zhao CTransl Oncol