Gene: KIF5C

3800
CDCBM2|KINN|NKHC|NKHC-2|NKHC2
kinesin family member 5C
protein-coding
2q23.1-q23.2
Ensembl:ENSG00000168280 MIM:604593 Vega:OTTHUMG00000153779 UniprotKB:O60282
NG_042216.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.493e-2 (AD)  3.832e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7577450chr2:149019447 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02380135chr2:149866270KIF5C1.600e-8Maternal smoking in pregnancy27040690
cg02380135chr2:149866270KIF5C4.690e-9Maternal smoking in pregnancy27040690
cg02380135chr2:149866270KIF5C4.600e-9Maternal smoking in pregnancy27040690
cg21303039chr2:149793681KIF5C1.300e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF1B0.871
H2AFV0.865
KIF5A0.852
RAPGEF40.849
NUCKS10.845
ZMYND110.842
KIF1A0.842
PTPN110.838
SPTBN10.836
NUDT30.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.803
OR4F5-0.782
S100A7-0.154
NPC1L1-0.142
GAGE10-0.129
NANOS2-0.126
SPDYC-0.125
NPVF-0.124
OR2T35-0.123
RAX2-0.121

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KIF5C mRNA"19167446
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of KIF5C mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF5C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF5C mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of KIF5C mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KIF5C gene27153756
D000447AldehydesAldehydes results in increased expression of KIF5C mRNA25014914
C547126AZM551248AZM551248 results in increased expression of KIF5C mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KIF5C mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of KIF5C mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of KIF5C mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of KIF5C protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of KIF5C mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of KIF5C mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of KIF5C mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF5C mRNA"27188386
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF5C mRNA20938992
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of KIF5C mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KIF5C mRNA"19167446
D016572CyclosporineCyclosporine results in decreased expression of KIF5C mRNA27989131
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of KIF5C mRNA21791302
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of KIF5C mRNA20920545
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of KIF5C mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of KIF5C mRNA26485663
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF5C mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF5C mRNA20938992
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KIF5C mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KIF5C mRNA24796395
D007854LeadLead affects the splicing of KIF5C mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KIF5C mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride affects the expression of KIF5C mRNA20864626
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of KIF5C protein26558463
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KIF5C mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of KIF5C protein26558463
C523184mocetinostatmocetinostat results in increased expression of KIF5C mRNA27255383
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of KIF5C mRNA22401849
C523799MRK 003KIF5C results in decreased susceptibility to MRK 00319903844
D009532NickelNickel results in increased expression of KIF5C mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of KIF5C mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of KIF5C mRNA20971185
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of KIF5C mRNA21791302
C046012pentanalpentanal results in increased expression of KIF5C mRNA26079696
D010795Phthalic AcidsPhthalic Acids results in decreased expression of KIF5C mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of KIF5C mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KIF5C mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of KIF5C mRNA20813756
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of KIF5C mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of KIF5C mRNA26079696
D012643SeleniumSelenium results in decreased expression of KIF5C mRNA19244175
D012834SilverSilver results in decreased expression of KIF5C mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of KIF5C mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KIF5C mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF5C mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KIF5C mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of KIF5C mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of KIF5C mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of KIF5C mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KIF5C mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of KIF5C mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of KIF5C mRNA19949822|2317975
D014638VanadatesVanadates results in decreased expression of KIF5C mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KIF5C gene25560391
D014810Vitamin EVitamin E results in decreased expression of KIF5C mRNA19244175
D015034Zinc OxideZinc Oxide analog results in decreased expression of KIF5C mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of KIF5C mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IBA21873635  
GO:0003777microtubule motor activity-TAS9782088  
GO:0005515protein binding-IPI15644324  19011756  19135897  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IEA-  
GO:0008574ATP-dependent microtubule motor activity, plus-end-directed-IBA21873635  
GO:0016887ATPase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006996organelle organization-TAS9782088  
GO:0007018microtubule-based movement-IBA21873635  
GO:0007411axon guidance-IBA21873635  
GO:0008045motor neuron axon guidance-IEA-  
GO:0030705cytoskeleton-dependent intracellular transport-IBA21873635  
GO:0048489synaptic vesicle transport-IBA21873635  
GO:0051028mRNA transport-ISS-  
GO:0098971anterograde dendritic transport of neurotransmitter receptor complex-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005871kinesin complex-IBA21873635  
GO:0005871kinesin complex-TAS9782088  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubule-IEA-  
GO:0030425dendrite-IEA-  
GO:0035253ciliary rootlet-IEA-  
GO:0043025neuronal cell body-ISS-  
GO:0044295axonal growth cone-ISS-  
GO:0150034distal axon-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal