Gene: KIR2DL3

3804
CD158B2|CD158b|GL183|KIR-023GB|KIR-K7b|KIR-K7c|KIR2DL|KIR2DS5|KIRCL23|NKAT|NKAT2|NKAT2A|NKAT2B|p58
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
protein-coding
19q13.42
Ensembl:ENSG00000243772 MIM:604938 Vega:OTTHUMG00000065887 UniprotKB:P43628
NG_046935.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.093e-1 (AD)  2.490e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRF10.68
KIR3DL10.637
GZMB0.628
GZMH0.615
NKG70.586
IL2RB0.582
TBX210.578
KLRD10.577
CD20.575
TRAT10.573

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKCZ-0.353
NPPC-0.342
NKAIN1-0.333
LGI3-0.33
HIST3H2A-0.33
MARCH11-0.328
BCL11A-0.327
HTR5A-0.327
CORT-0.325
UBE2T-0.324

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the expression of KIR2DL3 mRNA18414638
D001374AzacitidineAzacitidine results in decreased methylation of KIR2DL3 promoter19394699
D001374AzacitidineAzacitidine results in increased expression of KIR2DL3 mRNA18945643|1939469
D001374AzacitidineAzacitidine results in increased expression of KIR2DL3 protein19394699
D004958EstradiolEstradiol results in decreased expression of KIR2DL3 mRNA21632981
D002104CadmiumCadmium results in decreased expression of KIR2DL3 mRNA24376830
C012526quercitrinquercitrin affects the expression of KIR2DL3 mRNA25193878
D013806TheophyllineTheophylline results in decreased expression of KIR2DL3 mRNA18951874
D014635Valproic AcidValproic Acid results in increased methylation of KIR2DL3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003823antigen binding-TAS9059894  
GO:0005515protein binding-IPI8574854  8648092  8691154  9148918  18322206  18604210  
19858347  
GO:0038023signaling receptor activity-TAS7749980  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-TAS7749980  
GO:0007165signal transduction-IEA-  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9059894  
GO:0016021integral component of membrane-TAS7749980  
KEGG ID KEGG Term
hsa04612Antigen processing and presentation
hsa04650Natural killer cell mediated cytotoxicity
hsa05332Graft-versus-host disease
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26106958The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. (2015 Jun)Nishimura WEClinics (Sao Paulo)