Gene: KISS1

3814
HH13|KiSS-1
KiSS-1 metastasis suppressor
protein-coding
1q32.1
Ensembl:ENSG00000170498 MIM:603286 Vega:OTTHUMG00000036060 UniprotKB:Q15726
NG_032151.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.220e-1 (AD)  4.337e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAX0.569
WNT110.567
TRIM710.564
LRRC150.564
COL2A10.552
AQP80.541
IFNA50.538
ITK0.536
SLC25A310.53
LAMC20.527

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM196B-0.262
PLD5-0.26
FAM13C-0.257
PCDHA2-0.255
LMOD3-0.254
CNTNAP4-0.249
SYTL2-0.244
NXPH2-0.239
PCDHA11-0.237
MYO5B-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 protein"21190954
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of KISS1 mRNA"29112739
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [KISS1 protein results in increased abundance of Progesterone]23312234
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 protein"21190954
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KISS1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 mRNA"25510870
C5387582-aminoethyl diphenylborinate2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]18948403
C5387582-aminoethyl diphenylborinateTetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]]18948403
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of KISS1 protein"19442818
D000082AcetaminophenAcetaminophen results in decreased expression of KISS1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KISS1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of KISS1 mRNA21298039
C032739aroclor 1221aroclor 1221 results in decreased expression of KISS1 protein21190954
D001280AtrazineAtrazine affects the expression of KISS1 mRNA23847262
D004958Estradiolbisphenol A promotes the reaction [Estradiol results in increased expression of KISS1 mRNA]24532816
D004958EstradiolEstradiol affects the expression of KISS1 mRNA15919741
D004958EstradiolEstradiol results in decreased expression of KISS1 protein25269483
D004958EstradiolEstradiol results in increased expression of KISS1 mRNA24532816
D004958EstradiolEstradiol results in decreased expression of KISS1 mRNA25008887
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of KISS1 mRNA26653335
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of KISS1 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of KISS1 mRNA26653335
C006780bisphenol AFadrozole inhibits the reaction [bisphenol A results in increased expression of KISS1 mRNA]26653335
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of KISS1 mRNA]26653335
C006780bisphenol Abisphenol A promotes the reaction [Estradiol results in increased expression of KISS1 mRNA]24532816
C006780bisphenol Abisphenol A results in increased expression of KISS1 mRNA21182934|2453281
C006780bisphenol Abisphenol A results in increased expression of KISS1 protein24403293|2453281
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of KISS1 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of KISS1 mRNA19106226|2210100
C006780bisphenol Abisphenol A results in decreased expression of KISS1 protein19442818
C006780bisphenol Abisphenol A results in increased methylation of KISS1 gene28505145
D002118Calcium2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]18948403
D002118CalciumFlufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]18948403
D002118Calcium[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium18948403
D002118CalciumTetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]18948403
D002118CalciumTetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]]18948403
D003300CopperCopper deficiency results in increased expression of KISS1 mRNA26033743
C014347decitabinedecitabine results in increased expression of KISS1 mRNA16367923
D003976DiazinonDiazinon results in increased methylation of KISS1 gene22964155
D002945CisplatinKISS1 mRNA results in increased susceptibility to Cisplatin21383688
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of KISS1 mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of KISS1 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of KISS1 mRNA28871463
D004054DiethylstilbestrolDiethylstilbestrol affects the expression of KISS1 mRNA24316331
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of KISS1 mRNA24316331
C024629dimethyl phthalatedimethyl phthalate affects the expression of KISS1 mRNA26924002
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of KISS1 mRNA20019906
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of KISS1 protein20019906
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased expression of KISS1 mRNA19106226|2201656
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased expression of KISS1 protein19442818|2095179
D004967EstrogensEstrogens inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of KISS1 mRNA]26358002
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KISS1 mRNA29112739
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of KISS1 mRNA27395752
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of KISS1 mRNA25242408|2561553
D017316FadrozoleFadrozole inhibits the reaction [bisphenol A results in increased expression of KISS1 mRNA]26653335
D005411Flame RetardantsFlame Retardants results in increased expression of KISS1 mRNA29112739
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]18948403
D005557FormaldehydeFormaldehyde results in decreased expression of KISS1 mRNA28937961
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of KISS1 mRNA]26653335
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of KISS1 gene28505145
D019833GenisteinGenistein results in decreased expression of KISS1 protein20951797
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of KISS1 mRNA"28870491
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of KISS1 protein"28870491
C013099mancozebmancozeb affects the expression of KISS1 mRNA23660487
D008345ManganeseManganese results in increased expression of KISS1 mRNA23997110
D008550MelatoninMelatonin results in increased expression of KISS1 mRNA21647435
D008715Methionine[KISS1 protein modified form co-treated with Methionine] results in decreased expression of LHB protein27900820
D008727MethotrexateMethotrexate results in decreased expression of KISS1 mRNA17400583
D008731MethoxychlorMethoxychlor results in increased expression of KISS1 mRNA22016562
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KISS1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of KISS1 mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of KISS1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KISS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KISS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KISS1 mRNA"25620056
D010100OxygenOxygen deficiency results in increased expression of KISS1 mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 mRNA"25510870
C410127PCB 180"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 protein"21190954
C076994perfluorooctane sulfonic acidEstrogens inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of KISS1 mRNA]26358002
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KISS1 mRNA26358002
D010936Plant ExtractsPlant Extracts results in decreased expression of KISS1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of KISS1 mRNA22714537
D011374Progesterone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [KISS1 protein results in increased abundance of Progesterone]23312234
D011374ProgesteroneKISS1 protein promotes the reaction [CGB3 protein results in increased abundance of Progesterone]23312234
D011374ProgesteroneKISS1 protein results in increased abundance of Progesterone23312234
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of KISS1 mRNA27395752
D012722SewageSewage results in decreased expression of KISS1 mRNA20019906
D012722SewageSewage results in decreased expression of KISS1 protein20019906
D013629TamoxifenTamoxifen results in increased expression of KISS1 mRNA25123088
D013629TamoxifenTamoxifen results in decreased expression of KISS1 mRNA27395752
D013739TestosteroneTestosterone affects the expression of KISS1 protein25269483
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KISS1 mRNA21167638
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KISS1 mRNA22298810
D013779TetrodotoxinTetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]18948403
D013779TetrodotoxinTetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]]18948403
D013853ThioacetamideThioacetamide results in decreased expression of KISS1 mRNA23411599
C011559tributyltintributyltin inhibits the reaction [KISS1 protein results in increased secretion of LHB protein]28161095
D014303TrinitrotolueneTrinitrotoluene affects the expression of KISS1 mRNA21346803
C005445triphenyl phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KISS1 mRNA]"29112739
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KISS1 mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KISS1 mRNA]"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KISS1 mRNA"29112739
D014317Tritolyl Phosphates"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KISS1 mRNA]"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of KISS1 mRNA"29112739
D014635Valproic AcidValproic Acid results in increased expression of KISS1 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0005515protein binding-IPI11387329  
GO:0031773kisspeptin receptor binding-IBA21873635  
GO:0031773kisspeptin receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-TAS9192814  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0033686positive regulation of luteinizing hormone secretion-IEA-  
GO:0043410positive regulation of MAPK cascade-IEA-  
GO:0050806positive regulation of synaptic transmission-IEA-  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IEA-  
GO:0060112generation of ovulation cycle rhythm-IEA-  
GO:0060124positive regulation of growth hormone secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0016324apical plasma membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25127195Reduced levels of plasma kisspeptin during the antenatal booking visit are associated with increased risk of miscarriage. (2014 Dec)Jayasena CNJ Clin Endocrinol Metab
22320990Lack of germ line changes in KISS1 and KAI1 genes in sporadic head and neck cancer patients of Pakistani origin. (2011)Nazir MAsian Pac J Cancer Prev