Gene: KLK1

3816
KLKR|Klk6|hK1
kallikrein 1
protein-coding
19q13.33
Ensembl:ENSG00000167748 MIM:147910 Vega:OTTHUMG00000182876 UniprotKB:P06870
NG_012094.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.627e-1 (AD)  3.680e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02003184chr19:51324465KLK11.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CELA3B0.9
PNLIPRP10.899
CELA2A0.885
GP20.88
PLA2G1B0.878
CPB10.867
CTRC0.859
CTRB10.857
SPINK10.849
INS0.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM4SF20-0.198
ZPLD1-0.189
NPVF-0.181
GAPDHS-0.181
RSPH10B-0.179
CCDC87-0.173
FOXN4-0.172
SULT6B1-0.171
MYH8-0.167
C9orf57-0.166

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01370AluminiumSmall Molecule7429-90-5Approved|InvestigationalTarget
DB03127BenzamidineSmall Molecule618-39-3ExperimentalTarget
DB06245LanoteplaseBiotechDrug171870-23-8InvestigationalTarget
DB06692AprotininBiotechDrug9087-70-1Approved|Investigational|WithdrawnTarget
DB06728AnilineSmall Molecule62-53-3ExperimentalTarget
DB12598NafamostatSmall Molecule81525-10-2Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of KLK1 mRNA"26377693
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of KLK1 mRNA16788091
C0065004-aminobenzamidine4-aminobenzamidine binds to and results in decreased activity of KLK1 protein11151026
C0194984-nitroaniline4-nitroaniline binds to and results in decreased activity of KLK1 protein11151026
C0194984-nitroanilineKLK1 protein affects the metabolism of 4-nitroaniline analog2330740
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] affects the expression of KLK1 mRNA"25790727
D020106AcrylamideAcrylamide results in decreased expression of KLK1 mRNA28959563
D000447AldehydesAldehydes results in increased expression of KLK1 mRNA25014914
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of KLK1 mRNA28522335
D000535AluminumAluminum binds to and results in decreased activity of KLK1 protein15558947
D000584AmilorideKLK1 protein affects the susceptibility to [Amiloride results in increased secretion of Sodium]18086683
D000584AmilorideKLK1 protein results in increased susceptibility to Amiloride18086683
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLK1 mRNA16483693
C023650anilineaniline binds to and results in decreased activity of KLK1 protein11151026
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased activity of KLK1 protein"10777245
C032157benzamidinebenzamidine binds to and results in decreased activity of KLK1 protein11151026
D004958EstradiolEstradiol affects the expression of KLK1 mRNA15598610
C006780bisphenol Abisphenol A affects the expression of KLK1 mRNA25181051
D001966BromineBromine results in decreased expression of KLK1 mRNA21391292
C018475butyraldehydebutyraldehyde results in increased expression of KLK1 mRNA26079696
D002118CalciumCalcium results in decreased activity of KLK1 protein15558947
C081643candesartancandesartan results in decreased expression of KLK1 mRNA18796534
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KLK1 mRNA16644059
D002994ClofibrateClofibrate results in increased expression of KLK1 mRNA17585979
D003300CopperCopper deficiency results in increased expression of KLK1 mRNA26033743
D016572CyclosporineCyclosporine results in increased secretion of KLK1 protein21354196
D002945CisplatinKLK1 protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac results in increased expression of KLK1 protein23506792
D004041Dietary FatsDietary Fats results in increased expression of KLK1 mRNA18796534
D004280DobutamineKLK1 protein affects the susceptibility to Dobutamine12411458
C024565ethylene dichlorideethylene dichloride results in decreased expression of KLK1 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KLK1 mRNA23649840
C025314ferric citrateferric citrate results in decreased activity of KLK1 protein6421970
C020748ferrous sulfateferrous sulfate results in decreased activity of KLK1 protein6421970
D005419FlavonoidsFlavonoids results in increased expression of KLK1 mRNA18035473
D005632FructoseKLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]14568997
D005632FructoseKLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]14568997
D005632FructoseKLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA]14568997
C069837fullerene C60fullerene C60 results in decreased expression of KLK1 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of KLK1 mRNA20849911
D005839Gentamicinsicatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]]16401625
D005839Gentamicinsicatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]]16401625
D005839Gentamicinsicatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]]16401625
D005839GentamicinsKLK1 protein inhibits the reaction [Gentamicins results in decreased abundance of Nitric Oxide]16401625
D005839GentamicinsKLK1 protein inhibits the reaction [Gentamicins results in increased expression of CCL2 protein]16401625
D005839GentamicinsKLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]16401625
D005839GentamicinsKLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]16401625
D005839GentamicinsKLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]16401625
D005839GentamicinsKLK1 protein results in decreased susceptibility to Gentamicins16401625
D005839Gentamicins[KNG1 protein co-treated with KLK1] inhibits the reaction [Gentamicins results in increased activity of CASP3 protein]8160791
D006852HydrochlorothiazideHydrochlorothiazide results in increased expression of KLK1 mRNA18796534
D006854HydrocortisoneHydrocortisone results in increased export of KLK1 protein7473517
C065679icatibanticatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]]16401625
C065679icatibanticatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]]16401625
C065679icatibanticatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]]16401625
C065679icatibanticatibant inhibits the reaction [KLK1 protein results in increased abundance of Nitric Oxide]16401625
C082359imidaclopridimidacloprid results in decreased expression of KLK1 mRNA27782041
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of KLK1 mRNA"26377693
D008274MagnesiumMagnesium results in decreased activity of KLK1 protein15558947
D008727MethotrexateMethotrexate affects the expression of KLK1 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KLK1 mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of KLK1 mRNA15240709
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of KLK1 mRNA24810058
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] affects the expression of KLK1 mRNA"25790727
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KLK1 mRNA"25790727
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of KLK1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KLK1 mRNA"25620056
C028007nickel monoxidenickel monoxide results in decreased expression of KLK1 mRNA19167457
D009569Nitric Oxideicatibant inhibits the reaction [KLK1 protein results in increased abundance of Nitric Oxide]16401625
D009569Nitric OxideKLK1 protein inhibits the reaction [Gentamicins results in decreased abundance of Nitric Oxide]16401625
D009569Nitric OxideKLK1 protein results in increased abundance of Nitric Oxide16401625
C046012pentanalpentanal results in increased expression of KLK1 mRNA26079696
C414353phenylacetyl-Phe-Ser-Arg-N-(2,4-dinitrophenyl)ethylenediamine"phenylacetyl-Phe-Ser-Arg-N-(2,4-dinitrophenyl)ethylenediamine results in decreased activity of KLK1 protein"10882395
C006253pirinixic acidpirinixic acid results in decreased expression of KLK1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of KLK1 mRNA23557933
D011188PotassiumPotassium results in decreased activity of KLK1 protein15558947
D011188PotassiumPotassium results in increased expression of KLK1 protein11912256
D017419Potassium, Dietary"Potassium, Dietary results in increased expression of KLK1 protein"11912256
C005556propionaldehydepropionaldehyde results in increased expression of KLK1 mRNA26079696
C541923sandostatinLARsandostatinLAR results in decreased expression of KLK1 mRNA17210224
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased activity of KLK1 protein"10777245
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KLK1 mRNA25895662
D012964SodiumSodium results in decreased activity of KLK1 protein15558947
D012964SodiumKLK1 protein affects the susceptibility to [Amiloride results in increased secretion of Sodium]18086683
C016104sodium bichromatesodium bichromate results in increased expression of KLK1 mRNA22155349
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased expression of KLK1 mRNA"18796534
D012982Sodium, Dietary"Sodium, Dietary results in decreased expression of KLK1 protein"11912256
D013311StreptozocinStreptozocin results in increased expression of KLK1 mRNA19516248
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]16129698
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of IL1B protein]16129698
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGAL protein]16129698
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGAM protein]16129698
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGB2 protein]16129698
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of TNF protein]16129698
D013311StreptozocinKLK1 protein inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]16129698
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of KLK1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLK1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLK1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLK1 mRNA16267337
D013792ThalidomideThalidomide results in decreased expression of KLK1 mRNA26217789
C009495titanium dioxidetitanium dioxide results in increased expression of KLK1 mRNA23409001
D014212TretinoinTretinoin results in decreased expression of KLK1 mRNA16788091
D014241TrichloroethyleneTrichloroethylene results in increased expression of KLK1 mRNA25549359
C025643vinclozolinvinclozolin results in decreased expression of KLK1 mRNA23869203
C025643vinclozolinvinclozolin results in increased expression of KLK1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-NAS7749372  
GO ID GO Term Qualifier Evidence PubMed
GO:0002526acute inflammatory response-IBA21873635  
GO:0003073regulation of systemic arterial blood pressure-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0031638zymogen activation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19232384  
GO:0030141secretory granule-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23765970KLK1 A1789G gene polymorphism and the risk of coronary artery stenosis in the Chinese population. (2013 May 14)Li QDGenet Mol Res
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res