Gene: KLKB1

3818
KLK3|PKK|PKKD|PPK
kallikrein B1
protein-coding
4q35.2
Ensembl:ENSG00000164344 MIM:229000 Vega:OTTHUMG00000150347 UniprotKB:P03952
NG_012095.2
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.279e-1 (AD)  1.523e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC27A10.615
CRIP30.61
ZNF8140.593
ATP13A50.59
FAM186A0.589
COL5A30.568
IGDCC30.565
PLXNB10.558
TPCN10.558
BCAT20.557

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IBSP-0.34
SCARA5-0.333
CITED1-0.319
PYROXD1-0.316
LBH-0.305
CATSPERB-0.3
CTHRC1-0.299
SOGA3-0.299
GALR1-0.297
SLC5A1-0.29

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB05311EcallantideBiotechDrug460738-38-9Approved|InvestigationalTarget
DB06404Human C1-esterase inhibitorBiotechDrugApprovedTarget
DB09228Conestat alfaBiotechDrug80295-38-1Approved|InvestigationalTarget
DB12831GabexateSmall Molecule39492-01-8InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of KLKB1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of KLKB1 mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of KLKB1 mRNA]"22698814
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of KLKB1 mRNA"20566314
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of KLKB1 mRNA"21724226
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
C0920067-Ala-angiotensin (1-7)7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]25339356
C0920067-Ala-angiotensin (1-7)7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha]25339356
C0920067-Ala-angiotensin (1-7)KLKB1 gene mutant form results in increased susceptibility to 7-Ala-angiotensin (1-7)25339356
C496492abrineabrine results in decreased expression of KLKB1 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of KLKB1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of KLKB1 mRNA17562736
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of KLKB1 mRNA"20566314
D016604Aflatoxin B1Aflatoxin B1 affects the expression of KLKB1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KLKB1 mRNA22100608|2715375
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of KLKB1 mRNA"19936710
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLKB1 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of KLKB1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLKB1 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of KLKB1 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of KLKB1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of KLKB1 mRNA18958704
D002104CadmiumKLKB1 protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of KLKB1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of KLKB1 mRNA27339419
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of KLKB1 mRNA18636392
D002746Chlorpromazine[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA27344345
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of KLKB1 mRNA27344345
D002793Cholic Acids[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA27344345
D002809Chondroitin SulfatesChondroitin Sulfates analog results in increased activity of KLKB1 protein18434646
D002994ClofibrateClofibrate affects the expression of KLKB1 mRNA16081524
D002994ClofibrateClofibrate results in decreased expression of KLKB1 mRNA16081524
D002994ClofibrateClofibrate results in decreased expression of KLKB1 mRNA22300585
C009160cyclonitecyclonite results in increased expression of KLKB1 mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of KLKB1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in increased expression of KLKB1 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of KLKB1 mRNA23830897
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of KLKB1 mRNA"20566314
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KLKB1 mRNA17361019|2126653
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of KLKB1 mRNA19638242
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of KLKB1 mRNA"27840820
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of KLKB1 mRNA"23811387
C118739entinostatentinostat results in increased expression of KLKB1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of KLKB1 mRNA12655031
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of KLKB1 mRNA17555576
C024555ferric chlorideKLKB1 gene mutant form results in decreased susceptibility to ferric chloride25339356
D005485FlutamideFlutamide results in decreased expression of KLKB1 mRNA24136188
C039281furanfuran results in decreased expression of KLKB1 mRNA25539665|2619464
C007845gingerolgingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein]18030663
C007845gingerolgingerol results in decreased expression of KLKB1 protein18030663
D005978GlutathioneGlutathione deficiency results in increased expression of KLKB1 mRNA15345336
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of KLKB1 mRNA16206274
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of KLKB1 mRNA"20566314
D0151216-Ketoprostaglandin F1 alpha7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha]25339356
D0151216-Ketoprostaglandin F1 alphaKLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha25339356
D0151216-Ketoprostaglandin F1 alphanimesulide inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha]25339356
C011890kojic acidkojic acid results in decreased expression of KLKB1 mRNA16595896
D007854LeadLead results in decreased expression of KLKB1 mRNA19921347
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of KLKB1 mRNA12057914
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of KLKB1 mRNA"20566314
D008727MethotrexateMethotrexate results in increased expression of KLKB1 mRNA17400583
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KLKB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KLKB1 mRNA"25620056
D009285NaphthoquinonesNaphthoquinones results in increased expression of KLKB1 mRNA23811387
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of KLKB1 mRNA27344345
C012655nimesulideKLKB1 gene mutant form results in increased susceptibility to nimesulide25339356
C012655nimesulidenimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased expression of F3 mRNA]25339356
C012655nimesulidenimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]25339356
C012655nimesulidenimesulide inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha]25339356
C012655nimesulidenimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of KLF4 mRNA]25339356
C012655nimesulidenimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of SIRT1 mRNA]25339356
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of KLKB1 mRNA18636392
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of KLKB1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KLKB1 mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of KLKB1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of KLKB1 mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of KLKB1 mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of KLKB1 mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of KLKB1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of KLKB1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of KLKB1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KLKB1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLKB1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of KLKB1 mRNA18445702|2527062
C006253pirinixic acidpirinixic acid results in decreased expression of KLKB1 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of KLKB1 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of KLKB1 mRNA21278054
D012395Rose Bengal7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]25339356
D012395Rose BengalKLKB1 gene mutant form results in decreased susceptibility to Rose Bengal25339356
D012395Rose Bengalnimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]25339356
D012395Rose Bengalsplitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]25339356
C089730rosiglitazonerosiglitazone results in decreased expression of KLKB1 mRNA25572481
C444426splitomicinKLKB1 gene mutant form results in increased susceptibility to splitomicin25339356
C444426splitomicinsplitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]25339356
D013629TamoxifenTamoxifen affects the expression of KLKB1 mRNA14699072
D013629TamoxifenTamoxifen affects the expression of KLKB1 mRNA17555576
D013739Testosteronegingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein]18030663
D013739TestosteroneTestosterone results in increased expression of KLKB1 protein18030663
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLKB1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLKB1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLKB1 mRNA18796159|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLKB1 mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLKB1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLKB1 mRNA21215274|2172422
D013853ThioacetamideThioacetamide results in decreased expression of KLKB1 mRNA23411599
C012589trichostatin Atrichostatin A results in increased expression of KLKB1 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of KLKB1 mRNA25572481
D014520UrethaneUrethane results in decreased expression of KLKB1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLKB1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KLKB1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KLKB1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of KLKB1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KLKB1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of KLKB1 mRNA26682919
D015032ZincKLKB1 protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI2844223  
GO ID GO Term Qualifier Evidence PubMed
GO:0002542Factor XII activation-TAS2510163  
GO:0006508proteolysis-TAS1993180  
GO:0007597blood coagulation, intrinsic pathway-TAS-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0031638zymogen activation-TAS2510163  
GO:0031639plasminogen activation-IDA89876  
GO:0042730fibrinolysis-IEA-  
GO:0051919positive regulation of fibrinolysis-IDA89876  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA89876  
GO:0005886plasma membrane-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal