Gene: ARF6

382
-
ADP ribosylation factor 6
protein-coding
14q21.3
Ensembl:ENSG00000165527 MIM:600464 Vega:OTTHUMG00000140296 UniprotKB:P62330
NC_000014.9
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.704e-1 (AD)  6.734e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TPM40.842
CDC42SE10.834
P4HB0.832
KDELR20.829
ACBD30.827
WTAP0.827
PFN10.827
TXNDC50.826
PDIA30.824
EIF4A10.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.649
OR4F29-0.643
HES5-0.151
DIAPH3-0.15
REN-0.15
ZNF705B-0.14
TPPP2-0.14
C20orf85-0.138
HOXD4-0.138
OR4F16-0.137

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB018645'-Guanosine-Diphosphate-MonothiophosphateSmall MoleculeExperimentalTarget
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
DB08231Myristic acidSmall Molecule544-63-8ExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ARF6 mRNA"19162173
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl affects the expression of ARF6 mRNA"24050789
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ARF6 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ARF6 mRNA"21346803
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ARF6 mRNA20829426
D000082AcetaminophenAcetaminophen results in decreased expression of ARF6 mRNA27761495
D000082AcetaminophenAcetaminophen affects the expression of ARF6 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of ARF6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARF6 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARF6 mRNA19770486
C032311aluminum fluoridealuminum fluoride results in increased activity of ARF6 protein16280360
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ARF6 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ARF6 mRNA24449571
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ARF6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARF6 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARF6 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ARF6 mRNA"20382639
D004958EstradiolEstradiol promotes the reaction [ARF6 protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A affects the expression of ARF6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ARF6 mRNA28238728
C006780bisphenol AMIR149 mRNA inhibits the reaction [bisphenol A results in decreased expression of ARF6 mRNA]28238728
C006780bisphenol Abisphenol A affects the expression of ARF6 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ARF6 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of ARF6 mRNA20977926
D0200011-Butanol1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]10931844
D0200011-Butanol1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]10931844
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ARF6 mRNA15336504
D002101Cacodylic AcidCacodylic Acid results in increased expression of ARF6 mRNA16122865
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ARF6 mRNA27339419
D002713ChlorineChlorine results in increased expression of ARF6 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of ARF6 mRNA18636392
D003471CuprizoneCuprizone results in increased expression of ARF6 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of ARF6 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ARF6 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ARF6 mRNA21266533
D002945CisplatinARF6 protein affects the susceptibility to Cisplatin16217747
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ARF6 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of ARF6 mRNA26924002
D0197942,3-Diphosphoglycerate"2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]"10931844
D0197942,3-Diphosphoglycerate"2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]"10931844
D004237DiuronDiuron results in increased expression of ARF6 mRNA21551480
C012301domoic aciddomoic acid results in decreased expression of ARF6 mRNA18936300
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased methylation of ARF6 promoter27415467
D000431EthanolEthanol results in increased expression of ARF6 protein20133374
D009240N-Formylmethionine Leucyl-Phenylalanine1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]10931844
D009240N-Formylmethionine Leucyl-Phenylalanine1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]10931844
D009240N-Formylmethionine Leucyl-Phenylalanine"2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]"10931844
D009240N-Formylmethionine Leucyl-Phenylalanine"2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]"10931844
D009240N-Formylmethionine Leucyl-PhenylalanineARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]10931844
D009240N-Formylmethionine Leucyl-PhenylalanineARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]10931844
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine affects the localization of ARF6 protein10931844
D005839GentamicinsGentamicins results in increased expression of ARF6 mRNA22061828
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of ARF6 mRNA24680724
D017313FenretinideFenretinide results in increased expression of ARF6 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ARF6 mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the expression of ARF6 mRNA"11578593
D018021Lithium ChlorideLithium Chloride results in increased expression of ARF6 mRNA15711924
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ARF6 mRNA26924002
D009151Mustard GasMustard Gas affects the expression of ARF6 mRNA15651846
C051752nefazodonenefazodone results in increased expression of ARF6 mRNA24136188
C018620oleoresinsoleoresins results in increased expression of ARF6 mRNA20008804
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of ARF6 mRNA18636392
C410127PCB 180PCB 180 affects the expression of ARF6 mRNA24050789
D010416PentachlorophenolPentachlorophenol results in increased expression of ARF6 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ARF6 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of ARF6 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of ARF6 mRNA23091169
D011433PropranololPropranolol affects the localization of ARF6 protein16280360
D019269Phosphatidylinositol 4,5-Diphosphate"ARF6 protein affects the abundance of Phosphatidylinositol 4,5-Diphosphate"16280360
D012999SomanSoman results in increased expression of ARF6 mRNA19281266
D013481Superoxides1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]10931844
D013481Superoxides1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]10931844
D013481Superoxides"2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]"10931844
D013481Superoxides"2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]"10931844
D013481SuperoxidesARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]10931844
D013481SuperoxidesARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]10931844
C061133tamibarotenetamibarotene affects the expression of ARF6 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARF6 mRNA21570461|2468072
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of ARF6 protein10931844|1628036
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ARF6 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ARF6 mRNA28111298
D014212TretinoinTretinoin affects the expression of ARF6 mRNA15498508
D014520UrethaneUrethane results in increased expression of ARF6 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ARF6 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ARF6 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ARF6 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ARF6 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ARF6 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-TAS1993656  
GO:0005515protein binding-IPI9312003  16148947  16415858  17030804  17353931  18511905  
19644450  20727515  22522702  22580824  
GO:0005525GTP binding-IBA21873635  
GO:0005525GTP binding-TAS10913182  
GO:0031996thioesterase binding-IPI15509780  
GO:0047485protein N-terminus binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-IEA-  
GO:0006886intracellular protein transport-IBA21873635  
GO:0007049cell cycle-IEA-  
GO:0007155cell adhesion-TAS10036235  
GO:0015031protein transport-IEA-  
GO:0016192vesicle-mediated transport-IBA21873635  
GO:0016192vesicle-mediated transport-TAS10913182  
GO:0030838positive regulation of actin filament polymerization-IMP10036235  
GO:0030866cortical actin cytoskeleton organization-IDA10036235  
GO:0030866cortical actin cytoskeleton organization-IMP10913182  
GO:0032456endocytic recycling-IDA10036235  
GO:0033028myeloid cell apoptotic process-IEA-  
GO:0034394protein localization to cell surface-ISS-  
GO:0035020regulation of Rac protein signal transduction-IDA10036235  
GO:0036010protein localization to endosome-IBA21873635  
GO:0036010protein localization to endosome-IMP21951725  
GO:0048261negative regulation of receptor-mediated endocytosis-TAS9312003  
GO:0051301cell division-IEA-  
GO:0051489regulation of filopodium assembly-IDA14978216  
GO:0060998regulation of dendritic spine development-IBA21873635  
GO:0060998regulation of dendritic spine development-ISS-  
GO:0090162establishment of epithelial cell polarity-IEA-  
GO:0097178ruffle assembly-IDA10036235  
GO:0097284hepatocyte apoptotic process-IEA-  
GO:1903078positive regulation of protein localization to plasma membrane-ISS-  
GO:2000009negative regulation of protein localization to cell surface-IEA-  
GO:2000171negative regulation of dendrite development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IBA21873635  
GO:0001726ruffle-IDA9312003  
GO:0005737cytoplasm-IBA21873635  
GO:0005768endosome-IBA21873635  
GO:0005768endosome-IDA20682791  
GO:0005768endosome-TAS10913182  
GO:0005769early endosome-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IDA10036235  17398095  19948740  
GO:0005925focal adhesion-HDA21423176  
GO:0005938cell cortex-IDA10913182  
GO:0016020membrane-HDA19946888  
GO:0030139endocytic vesicle-IBA21873635  
GO:0030139endocytic vesicle-IDA19948740  
GO:0031527filopodium membrane-IDA14978216  
GO:0032154cleavage furrow-IDA23603394  
GO:0043209myelin sheath-IEA-  
GO:0055038recycling endosome membrane-IBA21873635  
GO:0055038recycling endosome membrane-IDA10036235  21951725  
GO:0055038recycling endosome membrane-TAS-  
GO:0070062extracellular exosome-HDA20458337  23533145  
GO:0090543Flemming body-IDA23603394  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04666Fc gamma R-mediated phagocytosis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6806834Signaling by METTAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8875656MET receptor recyclingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28607459The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. (2018 Mar)Gonzalez DAMol Psychiatry