Gene: KLRD1

3824
CD94
killer cell lectin like receptor D1
protein-coding
12p13.2
Ensembl:ENSG00000134539 MIM:602894 Vega:OTTHUMG00000168419 UniprotKB:Q13241
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.007e-2 (AD)  4.808e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4102739chr12:10327909 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL2RB0.834
PRF10.828
NCR10.812
FCRL30.81
TBX210.796
SLAMF60.782
SLAMF70.779
LY90.778
GZMA0.769
CD3G0.769

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.468
C16orf95-0.445
MYADML2-0.435
CHRNA4-0.434
CYP46A1-0.431
ASPDH-0.426
SLC45A1-0.423
EXTL1-0.422
OGDHL-0.421
BCL11A-0.421

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of KLRD1 mRNA"19162173
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of KLRD1 mRNA"21346803
D000082Acetaminophen[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of KLRD1 mRNA17093179
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of KLRD1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLRD1 mRNA16483693
C015001arsenitearsenite results in increased methylation of KLRD1 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of KLRD1 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of KLRD1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLRD1 mRNA22316170
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of KLRD1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLRD1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLRD1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of KLRD1 mRNA19484750
D002737ChloropreneChloroprene results in decreased expression of KLRD1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLRD1 mRNA20938992
D003907DexamethasoneDexamethasone results in increased expression of KLRD1 mRNA21041162
D004040Dietary Carbohydrates[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of KLRD1 mRNA17093179
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of KLRD1 mRNA28085963
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLRD1 mRNA20938992
D008627Mercuric ChlorideMercuric Chloride results in increased expression of KLRD1 mRNA27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLRD1 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of KLRD1 mRNA17400583
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KLRD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KLRD1 mRNA"25554681
D009532NickelNickel results in increased expression of KLRD1 mRNA24768652
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of KLRD1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of KLRD1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of KLRD1 mRNA26516004
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KLRD1 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLRD1 mRNA21041162
C009495titanium dioxidetitanium dioxide results in increased expression of KLRD1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of KLRD1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of KLRD1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of KLRD1 mRNA25729387
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KLRD1 gene25560391
D015032ZincZinc deficiency results in decreased expression of KLRD1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS7589107  
GO:0005515protein binding-IPI8046333  18083576  18448674  
GO:0023024MHC class I protein complex binding-IPI18448674  
GO:0023030MHC class Ib protein binding, via antigen binding groove-IPI25631937  
GO:0030246carbohydrate binding-IEA-  
GO:1990405protein antigen binding-IDA18448674  
GO ID GO Term Qualifier Evidence PubMed
GO:0002228natural killer cell mediated immunity-IDA18448674  
GO:0007166cell surface receptor signaling pathway-TAS7589107  
GO:0045087innate immune response-TAS-  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0043235receptor complex-IDA18448674  
KEGG ID KEGG Term
hsa04612Antigen processing and presentation
hsa04650Natural killer cell mediated cytotoxicity
hsa05332Graft-versus-host disease
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-2172127DAP12 interactionsTAS
R-HSA-2172127DAP12 interactionsIEA
R-HSA-2424491DAP12 signalingTAS
R-HSA-2424491DAP12 signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal