Gene: KPNA3

3839
IPOA4|SRP1|SRP1gamma|SRP4|hSRP1
karyopherin subunit alpha 3
protein-coding
13q14.2
Ensembl:ENSG00000102753 MIM:601892 Vega:OTTHUMG00000016922 UniprotKB:O00505
NC_000013.11
PubMed
0   ANCO-SNPs
OD|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.657e-1 (AD)  2.521e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAX1BP10.964
KPNA40.963
FAM8A10.958
CAPRIN10.955
CUL30.955
NUDT210.954
RAB140.952
MAP4K30.951
API50.95
RAB180.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.687
OR4F29-0.643
CSAG1-0.3
MTRNR2L10-0.291
MTRNR2L6-0.272
KLRB1-0.268
MTRNR2L9-0.265
MTRNR2L3-0.245
MS4A1-0.245
C8orf74-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of KPNA3 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of KPNA3 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of KPNA3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KPNA3 gene27153756
D001241AspirinAspirin results in increased expression of KPNA3 mRNA15928584
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of KPNA3 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KPNA3 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KPNA3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KPNA3 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of KPNA3 mRNA19167446
D004958EstradiolEstradiol results in increased expression of KPNA3 mRNA21632981
D004958EstradiolEstradiol affects the expression of KPNA3 mRNA15598610
C006780bisphenol Abisphenol A affects the expression of KPNA3 mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of KPNA3 gene28505145
C584509C646 compoundC646 compound results in decreased expression of KPNA3 mRNA26191083
C018021cobaltous chloridecobaltous chloride results in increased expression of KPNA3 mRNA19376846
D003375CoumestrolCoumestrol results in decreased expression of KPNA3 mRNA19167446
D017373Cyproterone AcetateCyproterone Acetate results in increased expression of KPNA3 mRNA16906019
D003907DexamethasoneDexamethasone results in decreased expression of KPNA3 mRNA16906019
D002945CisplatinCisplatin results in decreased expression of KPNA3 mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of KPNA3 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of KPNA3 mRNA]19030233
D002117CalcitriolCalcitriol results in decreased expression of KPNA3 mRNA16847355
D004147DioxinsDioxins affects the expression of KPNA3 mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of KPNA3 mRNA20530235
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of KPNA3 mRNA23649840
D018120FinasterideFinasteride results in increased expression of KPNA3 mRNA24136188
D005472FluorouracilFluorouracil results in decreased expression of KPNA3 mRNA16709241
D005485FlutamideFlutamide results in decreased expression of KPNA3 mRNA21126777
D005485FlutamideFlutamide results in increased expression of KPNA3 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of KPNA3 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of KPNA3 mRNA22634610
C544151jinfukangjinfukang results in decreased expression of KPNA3 mRNA27392435
D008727MethotrexateMethotrexate results in decreased expression of KPNA3 mRNA25339124
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of KPNA3 protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KPNA3 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KPNA3 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KPNA3 mRNA"20188158
D009151Mustard GasMustard Gas results in increased phosphorylation of KPNA3 protein19845377
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KPNA3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KPNA3 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of KPNA3 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of KPNA3 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in decreased expression of KPNA3 mRNA24642059
C006253pirinixic acidpirinixic acid results in increased expression of KPNA3 mRNA16906019
D011192Potassium DichromatePotassium Dichromate results in increased expression of KPNA3 protein23718831
D011374ProgesteroneProgesterone results in increased expression of KPNA3 mRNA23012394
D011794QuercetinQuercetin results in decreased expression of KPNA3 mRNA21632981
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of KPNA3 mRNA]19030233
D012406RoxarsoneRoxarsone results in decreased expression of KPNA3 protein21652273
D012715Sesame OilSesame Oil results in increased expression of KPNA3 mRNA29191790
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of KPNA3 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KPNA3 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KPNA3 mRNA22298810
D013853ThioacetamideThioacetamide results in increased expression of KPNA3 mRNA23411599
D013893ThiramThiram results in decreased expression of KPNA3 mRNA20530235
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of KPNA3 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of KPNA3 mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of KPNA3 mRNA22378314
D014501UraniumUranium affects the expression of KPNA3 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of KPNA3 mRNA15672453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KPNA3 gene25560391
D014810Vitamin EVitamin E results in decreased expression of KPNA3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10523667  15057270  16189514  19412186  19447967  21516116  
21988832  25036637  25416956  25910212  26382858  26496610  
27107014  27173435  
GO:0008022protein C-terminus binding-IEA-  
GO:0008139nuclear localization sequence binding-TAS9435235  
GO:0061608nuclear import signal receptor activity-IBA21873635  
GO:0061608nuclear import signal receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006607NLS-bearing protein import into nucleus-TAS9435235  
GO:0019054modulation by virus of host process-TAS-  
GO:0046718viral entry into host cell-IEA-  
GO:0065003protein-containing complex assembly-TAS9435235  
GO:0075732viral penetration into host nucleus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005643nuclear pore-TAS9154134  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
GO:0043657host cell-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1643685DiseaseTAS
R-HSA-168253Host Interactions with Influenza FactorsTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168256Immune SystemTAS
R-HSA-168276NS1 Mediated Effects on Host PathwaysTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22960338KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. (2012)Morris CPDis Markers