Gene: KPNA4

3840
IPOA3|QIP1|SRP3
karyopherin subunit alpha 4
protein-coding
3q25.33
Ensembl:ENSG00000186432 MIM:602970 Vega:OTTHUMG00000159033 UniprotKB:O00629
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.287e-1 (AD)  1.132e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KPNA30.963
CUL30.953
VAPA0.95
EIF2S10.95
CAPRIN10.95
RAD23B0.948
RAB140.946
TAX1BP10.945
ARL8B0.944
ARCN10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.712
OR4F29-0.672
CSAG1-0.28
MTRNR2L10-0.251
MTRNR2L9-0.24
MTRNR2L6-0.238
KLRB1-0.237
VNN3-0.233
MS4A1-0.233
FCRL1-0.224

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KPNA4 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KPNA4 mRNA"19167446
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of KPNA4 mRNA"19561079
D000082AcetaminophenAcetaminophen results in increased expression of KPNA4 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of KPNA4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KPNA4 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of KPNA4 mRNA24449571
D001280AtrazineAtrazine results in increased expression of KPNA4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KPNA4 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KPNA4 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of KPNA4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of KPNA4 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of KPNA4 mRNA25181051
D002104CadmiumCadmium results in increased expression of KPNA4 mRNA23369406
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KPNA4 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of KPNA4 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of KPNA4 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of KPNA4 mRNA19167446
C057862cyanoginosin LRcyanoginosin LR affects the expression of KPNA4 protein26984711
D016572CyclosporineCyclosporine results in increased expression of KPNA4 mRNA20106945|2556210
D017373Cyproterone AcetateCyproterone Acetate results in decreased expression of KPNA4 mRNA16906019
D002117CalcitriolCalcitriol results in decreased expression of KPNA4 mRNA16847355|1861484
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of KPNA4 mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of KPNA4 mRNA17547211
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KPNA4 protein23301498
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KPNA4 gene20938992
C416043galiellalactonegaliellalactone inhibits the reaction [RELA protein binds to KPNA4 protein]24631022
D017313FenretinideFenretinide results in decreased expression of KPNA4 mRNA28973697
D017313FenretinideFenretinide results in increased expression of KPNA4 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of KPNA4 mRNA19376150
C492448ICG 001ICG 001 results in increased expression of KPNA4 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KPNA4 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of KPNA4 mRNA27392435
D008627Mercuric ChlorideMercuric Chloride results in increased expression of KPNA4 mRNA16507785
D008694MethamphetamineMethamphetamine results in increased expression of KPNA4 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KPNA4 gene20938992
C063855microcystin RRmicrocystin RR results in increased expression of KPNA4 protein19111056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KPNA4 mRNA"25554681
D009532NickelNickel results in increased expression of KPNA4 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of KPNA4 mRNA17547211
D010416PentachlorophenolPentachlorophenol results in increased expression of KPNA4 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KPNA4 mRNA19010555
D010634PhenobarbitalPhenobarbital affects the expression of KPNA4 mRNA19159669
D019800PhenolPhenol results in increased expression of KPNA4 mRNA17547211
C006253pirinixic acidpirinixic acid results in increased expression of KPNA4 mRNA23811191
D010938Plant OilsPlant Oils results in increased expression of KPNA4 mRNA23370395
C045950propiconazolepropiconazole results in increased expression of KPNA4 mRNA21278054
D011794QuercetinQuercetin results in increased expression of KPNA4 mRNA21632981
D012406RoxarsoneRoxarsone results in decreased expression of KPNA4 protein21652273
D012834SilverSilver results in increased expression of KPNA4 mRNA26014281
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KPNA4 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KPNA4 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of KPNA4 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of KPNA4 mRNA20133372
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KPNA4 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of KPNA4 mRNA28973697
D014520UrethaneUrethane results in increased expression of KPNA4 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of KPNA4 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of KPNA4 gene29154799
C025643vinclozolinvinclozolin affects the expression of KPNA4 mRNA23869203
C025643vinclozolinvinclozolin results in increased expression of KPNA4 mRNA23034163|2355583

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9168958  10523667  20554775  20701745  20818336  25036637  
25416956  25599645  26496610  27107014  27173435  
GO:0061608nuclear import signal receptor activity-IBA21873635  
GO:0061608nuclear import signal receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006607NLS-bearing protein import into nucleus-TAS9395085  
GO:0019054modulation by virus of host process-TAS-  
GO:0042542response to hydrogen peroxide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1643685DiseaseTAS
R-HSA-168253Host Interactions with Influenza FactorsTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168256Immune SystemTAS
R-HSA-168276NS1 Mediated Effects on Host PathwaysTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24702466Clinical application of genetics to guide prevention and treatment of oral diseases. (2014 Jul)Kornman KSClin Genet