Gene: TNPO1

3842
IPO2|KPNB2|MIP|MIP1|TRN
transportin 1
protein-coding
5q13.2
Ensembl:ENSG00000083312 MIM:602901 Vega:OTTHUMG00000100967 UniprotKB:Q92973
NC_000005.10
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.984e-1 (AD)  3.290e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17483411chr5:72114851TNPO12.500e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SP30.907
TMED70.905
COPB10.904
CD1640.896
AFF40.896
UBXN40.89
LMAN10.885
COPB20.885
RB10.881
SREK10.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.647
OR4F29-0.599
HMHB1-0.193
NANOGNB-0.176
SPRR2A-0.168
OR8G1-0.168
SPRR2D-0.167
OR6C74-0.155
RNF223-0.154
MUC21-0.149

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of TNPO1 mRNA19041380
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of TNPO1 mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TNPO1 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of TNPO1 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNPO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of TNPO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNPO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of TNPO1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TNPO1 mRNA26497421|2906747
D000082AcetaminophenAcetaminophen affects the expression of TNPO1 mRNA17562736
C016601afimoxifeneafimoxifene results in decreased expression of TNPO1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TNPO1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TNPO1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNPO1 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of TNPO1 mRNA16514628
C044887beta-methylcholinebeta-methylcholine affects the expression of TNPO1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of TNPO1 mRNA21786754
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TNPO1 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of TNPO1 mRNA26079696
D002104CadmiumCadmium affects the expression of TNPO1 mRNA23369406
C037123cadmium sulfatecadmium sulfate results in increased expression of TNPO1 mRNA12064557|1467641
C054133casticincasticin results in decreased expression of TNPO1 mRNA28444820
C018021cobaltous chloridecobaltous chloride results in increased expression of TNPO1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of TNPO1 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of TNPO1 protein26984711
D016572CyclosporineCyclosporine results in increased expression of TNPO1 mRNA20106945|2556210
C000944dicrotophosdicrotophos results in decreased expression of TNPO1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of TNPO1 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of TNPO1 mRNA16847355
C118739entinostatentinostat results in decreased expression of TNPO1 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TNPO1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TNPO1 mRNA29097150
D005485FlutamideFlutamide results in increased expression of TNPO1 mRNA24136188
C070081fulvestrantfulvestrant results in decreased expression of TNPO1 mRNA16514628
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TNPO1 mRNA20044591
D007545IsoproterenolIsoproterenol results in increased expression of TNPO1 mRNA20003209
C544151jinfukangjinfukang results in decreased expression of TNPO1 mRNA27392435
D007649KetamineKetamine results in decreased expression of TNPO1 mRNA20080153
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of TNPO1 mRNA26667767
D008694MethamphetamineMethamphetamine results in increased expression of TNPO1 mRNA19564919
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in decreased expression of TNPO1 mRNA28349193
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TNPO1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TNPO1 mRNA23179753
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNPO1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNPO1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TNPO1 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in decreased expression of TNPO1 mRNA23892564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNPO1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TNPO1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of TNPO1 mRNA18445702
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TNPO1 mRNA16514628
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of TNPO1 mRNA26667767
C059514resveratrolresveratrol results in increased expression of TNPO1 protein25505154
D012643SeleniumSelenium results in decreased expression of TNPO1 mRNA19244175
D012999SomanSoman results in increased expression of TNPO1 mRNA19281266
C061133tamibarotenetamibarotene results in decreased expression of TNPO1 mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of TNPO1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNPO1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNPO1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNPO1 mRNA19465110
D013853ThioacetamideThioacetamide results in increased expression of TNPO1 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TNPO1 mRNA25729387
D014212TretinoinTretinoin affects the expression of TNPO1 mRNA15498508
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TNPO1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of TNPO1 mRNA28973697
D014501UraniumUranium affects the expression of TNPO1 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of TNPO1 mRNA15672453
D014520UrethaneUrethane results in increased expression of TNPO1 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of TNPO1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of TNPO1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TNPO1 mRNA26272509
D014635Valproic AcidValproic Acid results in decreased expression of TNPO1 mRNA23179753|2718838
C025643vinclozolinvinclozolin results in increased expression of TNPO1 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of TNPO1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI10668806  17435768  17474147  19124606  
GO:0008139nuclear localization sequence binding-IBA21873635  
GO:0008139nuclear localization sequence binding-TAS8808633  
GO:0008536Ran GTPase binding-IEA-  
GO:0008565protein transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000060protein import into nucleus, translocation-TAS9144189  
GO:0006607NLS-bearing protein import into nucleus-IBA21873635  
GO:0006610ribosomal protein import into nucleus-IBA21873635  
GO:0016032viral process-IEA-  
GO:0035735intraciliary transport involved in cilium assembly-TAS-  
GO:0043488regulation of mRNA stability-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS9144189  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS9144189  
GO:0005829cytosol-TAS-  
GO:0005929cilium-TAS-  
GO:0031965nuclear membrane-IBA21873635  
GO:0034399nuclear periphery-IBA21873635  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-450513Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620924Intraflagellar transportTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal