Gene: KRT1

3848
CK1|EHK|EHK1|EPPK|K1|KRT1A|NEPPK
keratin 1
protein-coding
12q13.13
Ensembl:ENSG00000167768 MIM:139350 Vega:OTTHUMG00000169749 UniprotKB:P04264
NG_008364.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.914e-1 (AD)  3.794e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs14024chr12:52675230 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02377704chr12:53075359KRT12.900e-13Smoking27651444
cg03348792chr12:53075482KRT11.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT140.89
KRT20.863
CALML50.842
FLG20.84
KRTDAP0.816
CASP140.78
TNS40.745
SERPINA120.725
MB0.714
KRT770.702

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POM121L2-0.264
NPBWR2-0.248
NKPD1-0.246
FCHO1-0.245
CDH17-0.245
OR2M4-0.245
RHO-0.243
HARBI1-0.241
IL17F-0.24
CBX8-0.238

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C40306510-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide binds to KRT1 protein19539807
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]"12069687
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Calcium results in increased expression of KRT1 mRNA]21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Calcium results in increased expression of KRT1 protein]21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of KRT1 mRNA]21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of KRT1 protein]21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of KRT1 mRNA21524694
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of KRT1 protein21524694
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in decreased expression of KRT1 mRNA25781201
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of KRT1 protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of KRT1 mRNA"20852150
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of KRT1 protein"20852150
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of KRT1 mRNA15982314
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of KRT1 protein"24455688
C0476288-hydroxyeicosatetraenoic acid8-hydroxyeicosatetraenoic acid promotes the reaction [Calcium results in increased expression of KRT1 mRNA]12069687
D000082AcetaminophenAcetaminophen results in decreased expression of KRT1 mRNA22230336|2669055
D000082AcetaminophenAcetaminophen results in decreased expression of KRT1 protein22230336
D019342Acetic AcidAcetic Acid results in decreased expression of KRT1 protein21296659
C103303alitretinoinalitretinoin results in decreased expression of KRT1 mRNA15982314
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of KRT1 mRNA24449571
D001149ArsenatesArsenates results in decreased expression of KRT1 mRNA9219563
D001151ArsenicArsenic affects the methylation of KRT1 gene25304211
D001151ArsenicArsenic results in increased expression of KRT1 mRNA11134558
D001151ArsenicArsenic results in increased expression of KRT1 protein19818359
C015001arsenitearsenite results in decreased expression of KRT1 mRNA18633435
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KRT1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KRT1 mRNA21839799
C075388beta-damascenonebeta-damascenone results in increased expression of KRT1 mRNA22982537
D004958EstradiolEstradiol results in decreased expression of KRT1 mRNA28701262
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT1 mRNA]28701262
C006780bisphenol Abisphenol A affects the expression of KRT1 mRNA28701262
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A affects the expression of KRT1 mRNA]28701262
C006780bisphenol Abisphenol A results in decreased methylation of KRT1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of KRT1 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of KRT1 protein21296659
D002104CadmiumKRT1 protein binds to Cadmium23896426
D002118Calcium2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Calcium results in increased expression of KRT1 mRNA]21524694
D002118Calcium2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Calcium results in increased expression of KRT1 protein]21524694
D002118CalciumCalcium results in increased expression of KRT1 mRNA21524694|2465850
D002118CalciumCalcium results in increased expression of KRT1 protein21524694|2465850
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]24658506
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of KRT1 protein]24658506
D002118CalciumCTNNB1 mutant form inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]24658506
D002118CalciumCTNNB1 mutant form inhibits the reaction [Calcium results in increased expression of KRT1 protein]24658506
D002118CalciumSB 203580 inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]21524694
D002118CalciumSB 203580 inhibits the reaction [Calcium results in increased expression of KRT1 protein]21524694
D002118CalciumWNT5A protein promotes the reaction [Calcium results in increased expression of KRT1 mRNA]24658506
D002118CalciumWNT5A protein promotes the reaction [Calcium results in increased expression of KRT1 protein]24658506
D002118Calcium"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]"12069687
D002118Calcium"15-hydroxy-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]"12069687
D002118Calcium8-hydroxyeicosatetraenoic acid promotes the reaction [Calcium results in increased expression of KRT1 mRNA]12069687
D002118CalciumCalcium results in increased expression of KRT1 mRNA12069687
D002118CalciumMasoprocol inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]12069687
D002118Calciummorin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]12069687
D002118CalciumQuercetin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]12069687
D002840ChromatesChromates results in decreased expression of KRT1 mRNA9219563
D002994ClofibrateClofibrate results in increased expression of KRT1 protein19952500
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in decreased expression of KRT1 mRNA20105288
D003300CopperKRT1 protein binds to Copper23896426
D003471CuprizoneCuprizone results in increased expression of KRT1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of KRT1 mRNA21163907
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of KRT1 mRNA15171707
D004317DoxorubicinDoxorubicin affects the expression of KRT1 protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KRT1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of KRT1 mRNA17555576
D005472FluorouracilFluorouracil affects the expression of KRT1 protein21296659
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A affects the expression of KRT1 mRNA]28701262
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT1 mRNA]28701262
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT1 mRNA19748995
C479979GW0742PPARD protein mutant form inhibits the reaction [[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT1 mRNA]19748995
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]"12069687
D007854LeadKRT1 protein binds to Lead23896426
D009637MasoprocolMasoprocol inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]12069687
D008628MercuryMercury results in increased expression of KRT1 mRNA19937285
D015741MetriboloneMetribolone results in decreased expression of KRT1 protein17152098
C008548morinmorin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]12069687
D009020MorphineMorphine results in decreased expression of KRT1 protein23056601
D009151Mustard Gas2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of KRT1 mRNA]21524694
D009151Mustard Gas2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of KRT1 protein]21524694
D009151Mustard GasMustard Gas results in increased cleavage of KRT1 protein12482751
D009151Mustard GasMustard Gas results in increased expression of KRT1 mRNA21524694
D009151Mustard GasMustard Gas results in increased expression of KRT1 protein11428642|2152469
D009151Mustard GasSB 203580 inhibits the reaction [Mustard Gas results in increased expression of KRT1 mRNA]21524694
D009151Mustard GasSB 203580 inhibits the reaction [Mustard Gas results in increased expression of KRT1 protein]21524694
D009151Mustard GasMustard Gas results in increased expression of KRT1 mRNA21939433
D009532NickelKRT1 protein binds to Nickel23896426
C014707nitrosobenzylmethylamine[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of KRT1 mRNA12517797
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of KRT1 mRNA17616710
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]"23566955
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT1 mRNA]"23566955
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT1 mRNA"18633435
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of KRT1 protein19716841
D010126OzoneOzone results in increased expression of KRT1 mRNA27206323
C025319phenyl isocyanatephenyl isocyanate analog binds to KRT1 protein26070416
D011192Potassium DichromatePotassium Dichromate results in increased expression of KRT1 protein23718831
D011192Potassium DichromatePotassium Dichromate results in increased expression of KRT1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of KRT1 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of KRT1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of KRT1 protein17292933
D011794QuercetinQuercetin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]12069687
D015474IsotretinoinIsotretinoin results in decreased expression of KRT1 mRNA15982314
C089730rosiglitazonerosiglitazone results in increased expression of KRT1 mRNA23166672
D012406RoxarsoneRoxarsone results in decreased expression of KRT1 protein25903172
C541923sandostatinLARsandostatinLAR results in increased expression of KRT1 mRNA17210224
C093642SB 203580SB 203580 inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]21524694
C093642SB 203580SB 203580 inhibits the reaction [Calcium results in increased expression of KRT1 protein]21524694
C093642SB 203580SB 203580 inhibits the reaction [Mustard Gas results in increased expression of KRT1 mRNA]21524694
C093642SB 203580SB 203580 inhibits the reaction [Mustard Gas results in increased expression of KRT1 protein]21524694
C093642SB 203580SB 203580 results in decreased expression of KRT1 mRNA21524694
C093642SB 203580SB 203580 results in decreased expression of KRT1 protein21524694
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of KRT1 protein25895662
C017947sodium arsenitesodium arsenite results in increased expression of KRT1 mRNA16356559
C017947sodium arseniteCARM1 mutant form inhibits the reaction [sodium arsenite results in decreased expression of KRT1 mRNA]23699174
C017947sodium arsenitePRMT1 mutant form inhibits the reaction [sodium arsenite results in decreased expression of KRT1 mRNA]23699174
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]23566955
C017947sodium arsenitesodium arsenite inhibits the reaction [U 0126 results in increased expression of KRT1 mRNA]23566955
C017947sodium arsenitesodium arsenite results in decreased expression of KRT1 mRNA23566955|2369917
C017947sodium arsenitesodium arsenite results in increased expression of KRT1 mRNA19524636
C017947sodium arsenitesodium arsenite results in increased expression of KRT1 protein18572023|1952463
C017947sodium arsenitesodium arsenite results in decreased expression of KRT1 protein24866292
D013605T-2 ToxinT-2 Toxin results in decreased expression of KRT1 mRNA26141394
D013629TamoxifenTamoxifen affects the expression of KRT1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KRT1 mRNA9525283
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KRT1 mRNA27404394|2748027
D014118Toxins, Biological"Toxins, Biological affects the expression of KRT1 mRNA"19682533
D014212TretinoinTretinoin metabolite results in increased expression of KRT1 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of KRT1 mRNA15982314
D014212TretinoinTretinoin results in increased expression of KRT1 protein16619266
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNA20105288
C002802tungsten carbidetungsten carbide results in decreased expression of KRT1 mRNA20105288
C101044tyrphostin AG 1478tyrphostin AG 1478 results in increased expression of KRT1 protein18633435
C113580U 0126"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT1 mRNA]"23566955
C113580U 0126sodium arsenite inhibits the reaction [U 0126 results in increased expression of KRT1 mRNA]23566955
C113580U 0126U 0126 results in increased expression of KRT1 mRNA23566955
D014520UrethaneUrethane results in increased expression of KRT1 mRNA28818685
D014638VanadatesVanadates results in decreased expression of KRT1 mRNA9219563
D014800VitalliumVitallium analog results in increased expression of KRT1 mRNA23825117
D015032ZincKRT1 protein binds to Zinc23896426
D015032Zinc[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of KRT1 mRNA12517797

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11290596  16923132  25910212  
GO:0030246carbohydrate binding-IPI11549596  
GO:0030280structural constituent of epidermis-IDA7543090  
GO:0038023signaling receptor activity-NAS11290596  
GO:0046982protein heterodimerization activity-IDA27595935  
GO ID GO Term Qualifier Evidence PubMed
GO:0001867complement activation, lectin pathway-IPI11549596  
GO:0001895retina homeostasis-HEP23580065  
GO:0006979response to oxidative stress-NAS11549596  
GO:0007165signal transduction-IEA-  
GO:0018149peptide cross-linking-IDA7543090  
GO:0031424keratinization-TAS-  
GO:0042730fibrinolysis-NAS11290596  
GO:0043312neutrophil degranulation-TAS-  
GO:0045765regulation of angiogenesis-NAS11290596  
GO:0051290protein heterotetramerization-IDA27595935  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IDA7543090  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA22664934  23580065  
GO:0005634nucleus-HDA21630459  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-TAS1381288  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IDA11290596  
GO:0031012extracellular matrix-HDA23658023  
GO:0045095keratin filament-IEA-  
GO:0070062extracellular exosome-HDA11487543  19199708  23533145  
GO:0072562blood microparticle-HDA22516433  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28944608Coexistence of mutations in keratin 10 (KRT10) and the mitochondrial genome in a patient with ichthyosis with confetti and Leber's hereditary optic neuropathy. (2017 Nov)Kalinska-Bienias AAm J Med Genet A