Gene: KRT3

3850
CK3|K3
keratin 3
protein-coding
12q13.13
Ensembl:ENSG00000186442 MIM:148043 Vega:OTTHUMG00000169799 UniprotKB:P12035
NG_008350.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.628e-1 (AD)  5.163e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12312467chr12:52790941 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FSCN20.429
ASAH2B0.419
SNCG0.416
CPNE70.414
KLK100.413
SMPX0.412
RET0.41
KLK70.409
TDO20.403
RAB370.399

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITPRIP-0.327
EFNA4-0.327
CXCL1-0.319
TNFRSF10D-0.315
CSF1-0.312
P4HA1-0.311
C22orf31-0.307
GPR4-0.3
ZHX2-0.298
FGF11-0.296

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of KRT3 mRNA22378314
C517284monomethyl phthalatemonomethyl phthalate affects the expression of KRT3 mRNA26924002

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IMP9171831  
GO ID GO Term Qualifier Evidence PubMed
GO:0030855epithelial cell differentiation-ISS-  
GO:0031424keratinization-TAS-  
GO:0045104intermediate filament cytoskeleton organization-IMP9171831  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005882intermediate filament-NAS9171831  
GO:0045095keratin filament-TAS9171831  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal