Gene: KRT6A

3853
CK-6C|CK-6E|CK6A|CK6C|CK6D|K6A|K6C|K6D|KRT6C|KRT6D|PC3
keratin 6A
protein-coding
12q13.13
Ensembl:ENSG00000205420 MIM:148041 Vega:OTTHUMG00000169597 UniprotKB:P02538
NG_008298.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.251e-1 (AD)  7.812e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPRR1A0.909
KRT130.876
SPRR1B0.841
SPRR30.834
KRT6C0.825
KRT40.81
CRNN0.809
SPRR2A0.799
MUC210.789
SPRR2D0.788

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYBB3-0.269
MBOAT4-0.248
CPSF4L-0.229
GRK7-0.226
CDC25A-0.224
PCDHB6-0.217
NPIPB15-0.209
KLHL15-0.206
LRCH2-0.206
ZNF268-0.203

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of KRT6A mRNA15982314
D000111AcetylcysteineAcetylcysteine inhibits the reaction [titanium dioxide results in decreased expression of KRT6A mRNA]20932892
C103303alitretinoinalitretinoin results in decreased expression of KRT6A mRNA15982314
D001151ArsenicArsenic results in increased expression of KRT6A mRNA18414623
D001151ArsenicArsenic results in increased expression of KRT6A protein18414623
C006632arsenic trioxidearsenic trioxide results in increased expression of KRT6A mRNA15949261
C015001arsenitearsenite results in increased expression of KRT6A mRNA28501331
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KRT6A mRNA23735875
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of KRT6A mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT6A mRNA19619570
D004958EstradiolEstradiol results in decreased expression of KRT6A mRNA23019147
D004958EstradiolEstradiol results in increased expression of KRT6A mRNA19619570
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of KRT6A mRNA17404688
C006780bisphenol Abisphenol A results in increased methylation of KRT6A promoter27312807
C515564bromovaninbromovanin results in decreased expression of KRT6A protein21419150
D002104CadmiumCadmium results in increased expression of KRT6A mRNA18414623
D002104CadmiumCadmium results in increased expression of KRT6A protein18414623
D002104CadmiumKRT6A protein binds to Cadmium23896426
C100187chloropicrinchloropicrin affects the expression of KRT6A mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of KRT6A mRNA24374135
D003300CopperCopper results in increased expression of KRT6A protein22480594
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of KRT6A mRNA]21095227
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of KRT6A mRNA15171707|1663631
D002117CalcitriolCalcitriol results in increased expression of KRT6A mRNA26485663
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased methylation of KRT6A promoter24675093
D000431EthanolEthanol results in increased expression of KRT6A mRNA28069986
D005472FluorouracilFluorouracil affects the expression of KRT6A mRNA16584549
C010974glyphosateglyphosate affects the expression of KRT6A protein20045496
C013099mancozebmancozeb results in decreased expression of KRT6A protein21375462
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KRT6A mRNA"25926378
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of KRT6A mRNA"25926378
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KRT6A mRNA"25926378
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of KRT6A mRNA"25926378
D009532NickelNickel results in increased expression of KRT6A mRNA24768652
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of KRT6A protein19716841
D011192Potassium DichromatePotassium Dichromate results in increased expression of KRT6A protein23718831
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of KRT6A mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of KRT6A mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of KRT6A mRNA17404688
D015474IsotretinoinIsotretinoin results in decreased expression of KRT6A mRNA15982314
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of KRT6A protein25895662
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of KRT6A mRNA]21095227
C017947sodium arsenitesodium arsenite results in increased expression of KRT6A mRNA12016162|2145756
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT6A mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KRT6A mRNA16704738|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KRT6A mRNA17035482
D019284ThapsigarginThapsigargin results in decreased expression of KRT6A protein21692457
C009495titanium dioxideAcetylcysteine inhibits the reaction [titanium dioxide results in decreased expression of KRT6A mRNA]20932892
C009495titanium dioxidetitanium dioxide results in decreased expression of KRT6A mRNA20932892
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KRT6A protein27818348
D014212TretinoinTretinoin metabolite results in decreased expression of KRT6A mRNA15982314
D014212TretinoinTretinoin results in decreased expression of KRT6A mRNA15982314
D015032ZincKRT6A protein binds to Zinc23896426
D015032ZincZinc deficiency results in increased expression of KRT6A mRNA20857495

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0031424keratinization-TAS-  
GO:0045104intermediate filament cytoskeleton organization-IMP23662636  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005882intermediate filament-NAS9054461  
GO:0045095keratin filament-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28619761Exhaled breath condensate biomarkers for the early diagnosis of lung cancer using proteomics. (2017 Oct 1)Lopez-Sanchez LMAm J Physiol Lung Cell Mol Physiol