Gene: KRT6B

3854
CK-6B|CK6B|K6B|KRTL1|PC2|PC4
keratin 6B
protein-coding
12q13.13
Ensembl:ENSG00000185479 MIM:148042 Vega:OTTHUMG00000169593 UniprotKB:P04259
NG_008299.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.043e-1 (AD)  9.651e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT160.838
KRT6C0.834
SPINK50.782
KRT6A0.768
SPRR1B0.75
SPRR2D0.742
SPRR1A0.731
FGFBP10.73
KRT150.714
CSTA0.707

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GREB1-0.28
TMEM56-0.279
MOXD1-0.276
PCDHGB1-0.262
SORCS2-0.261
CYS1-0.259
KIF11-0.256
ABCD2-0.247
PDZD9-0.246
PCDHGA2-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of KRT6B mRNA"24172598
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KRT6B gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of KRT6B mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KRT6B mRNA20127859|2373587
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT6B mRNA19619570
D004958EstradiolEstradiol results in decreased expression of KRT6B mRNA23019147
D004958EstradiolEstradiol results in increased expression of KRT6B mRNA19619570
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of KRT6B mRNA17404688
D002104CadmiumKRT6B protein binds to Cadmium23896426
D002104CadmiumCadmium results in decreased expression of KRT6B mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KRT6B mRNA26472689
D004041Dietary FatsDietary Fats results in decreased expression of KRT6B mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of KRT6B mRNA15171707|1663631
D002117CalcitriolCalcitriol results in increased expression of KRT6B mRNA26485663
D004237DiuronDiuron metabolite results in increased expression of KRT6B mRNA24172598
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KRT6B protein23301498
D005557FormaldehydeFormaldehyde results in decreased expression of KRT6B mRNA28937961
D017313FenretinideFenretinide results in decreased expression of KRT6B mRNA16467112
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KRT6B mRNA26752646
D007854LeadKRT6B protein binds to Lead23896426
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of KRT6B protein24625837
D009151Mustard GasMustard Gas results in increased alkylation of KRT6B protein18342354
D009151Mustard GasMustard Gas results in increased expression of KRT6B mRNA25102026
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of KRT6B mRNA16467112
D009532NickelNickel results in increased expression of KRT6B mRNA24768652|2558310
D009538NicotineNicotine results in increased expression of KRT6B mRNA23825647
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of KRT6B mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of KRT6B mRNA27935865
C025319phenyl isocyanatephenyl isocyanate analog binds to KRT6B protein26070416
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of KRT6B mRNA27935865
D011192Potassium DichromatePotassium Dichromate results in decreased expression of KRT6B protein23718831
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of KRT6B mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of KRT6B mRNA17404688
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT6B mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KRT6B mRNA19619570
D014118Toxins, Biological"Toxins, Biological affects the expression of KRT6B mRNA"19682533
D014635Valproic AcidValproic Acid affects the expression of KRT6B mRNA17963808
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of KRT6B mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005200structural constituent of cytoskeleton-TAS9618173  
GO:0005515protein binding-IPI16189514  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0007398ectoderm development-TAS9618173  
GO:0031424keratinization-TAS-  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0045095keratin filament-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28619761Exhaled breath condensate biomarkers for the early diagnosis of lung cancer using proteomics. (2017 Oct 1)Lopez-Sanchez LMAm J Physiol Lung Cell Mol Physiol