Gene info: ID 3858

Gene: KRT10

GENE ID: 3858

Synonyms: BCIE|BIE|CK10|EHK|K10|KPP

Description: keratin 10

Gene type: protein-coding

Location: 17q21.2

dbXrefs: Ensembl:ENSG00000186395 MIM:148080 Vega:OTTHUMG00000133368 UniprotKB:P13645

RefSeq: NG_008405.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.530e-1 (AD) 8.021e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RPL35A	0.724
RPL24	0.715
TMA7	0.712
RPL14	0.711
MSRB2	0.709
POLR2J	0.707
RPL17	0.704
RPS7	0.702
RPL31	0.701
GTF3C6	0.697

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.598
OR4F29	-0.57
OR2M4	-0.239
IL1RAPL2	-0.202
NPBWR2	-0.186
WDR87	-0.186
LINC00348	-0.184
PCDHA7	-0.18
PROKR2	-0.171
PCDHA6	-0.17

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KRT10 mRNA"	19114083
C029955	2-nitrotoluene	2-nitrotoluene results in decreased expression of KRT10 protein	22434383
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of KRT10 protein"	23457121
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of KRT10 protein	24140754
C033170	4-bromo-A-23187	4-bromo-A-23187 results in increased expression of KRT10 mRNA	16621454
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of KRT10 mRNA	15982314
D000082	Acetaminophen	Acetaminophen affects the expression of KRT10 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of KRT10 mRNA	27153756
C103303	alitretinoin	alitretinoin results in decreased expression of KRT10 mRNA	15982314
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of KRT10 mRNA	28713220
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of KRT10 protein	28713220
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of KRT10 mRNA	24449571
D001149	Arsenates	Arsenates results in decreased expression of KRT10 mRNA	9219563
C015001	arsenite	arsenite results in decreased expression of KRT10 mRNA	18633435
C015001	arsenite	arsenite results in decreased expression of KRT10 protein	18633435
C015001	arsenite	JAG1 protein inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]	18633435
C015001	arsenite	tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]	18633435
C015001	arsenite	tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of KRT10 protein]	18633435
C547126	AZM551248	AZM551248 results in decreased expression of KRT10 mRNA	22323515
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of KRT10 mRNA	16985168
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in decreased expression of KRT10 protein modified form	24464499
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of KRT10 mRNA"	19150397
C075388	beta-damascenone	beta-damascenone results in increased expression of KRT10 mRNA	22982537
D004958	Estradiol	Estradiol results in decreased expression of KRT10 mRNA	23019147\|2870126
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT10 mRNA]	28701262
D004958	Estradiol	Estradiol results in decreased expression of KRT10 mRNA	19484750
C006780	bisphenol A	bisphenol A affects the expression of KRT10 mRNA	28701262
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A affects the expression of KRT10 mRNA]	28701262
C006780	bisphenol A	bisphenol A results in increased expression of KRT10 mRNA	25594700
C006780	bisphenol A	bisphenol A results in decreased expression of KRT10 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased phosphorylation of KRT10 protein	22174045
C515564	bromovanin	bromovanin results in decreased expression of KRT10 protein	21419150
D002104	Cadmium	KRT10 protein binds to Cadmium	23896426
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of KRT10 mRNA	25993096
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of KRT10 protein	21699967
C055085	calcipotriene	calcipotriene results in decreased expression of KRT10 protein	7508215
D000074262	Canola Oil	Canola Oil metabolite results in decreased expression of KRT10 mRNA	27363782
C007020	chlorophyllin	chlorophyllin analog results in increased expression of KRT10 protein	22852132
C100187	chloropicrin	chloropicrin results in increased expression of KRT10 mRNA	26352163
D002840	Chromates	Chromates results in decreased expression of KRT10 mRNA	9219563
C041167	chromium nitrate	chromium nitrate results in increased expression of KRT10 protein	19771553
D003300	Copper	KRT10 protein binds to Copper	23896426
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of KRT10 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of KRT10 mRNA	21163907\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of KRT10 mRNA	23308384\|2504735
D016572	Cyclosporine	Cyclosporine results in increased expression of KRT10 protein	23308384\|2504735
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of KRT10 protein	19550292
D015946	Ethylene Dibromide	Ethylene Dibromide results in decreased expression of KRT10 protein	22434383
D002945	Cisplatin	Cisplatin results in decreased expression of KRT10 mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of KRT10 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of KRT10 mRNA	18042831
D004052	Diethylnitrosamine	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of KRT10 protein"	23457121
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of KRT10 mRNA	15171707
D002117	Calcitriol	Calcitriol results in decreased expression of KRT10 protein	7508215
D002117	Calcitriol	Calcitriol results in increased expression of KRT10 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of KRT10 mRNA	21592394
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of KRT10 mRNA"	22485181
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of KRT10 mRNA	26924002
D004317	Doxorubicin	Doxorubicin affects the expression of KRT10 protein	29385562
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KRT10 protein	23301498
D000431	Ethanol	Ethanol results in increased expression of KRT10 protein	23200777
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of KRT10 mRNA	15576828
D015025	Zearalenone	Zearalenone results in decreased expression of KRT10 protein	25058043
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A affects the expression of KRT10 mRNA]	28701262
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT10 mRNA]	28701262
C479979	GW0742	[[GW0742 binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA	19748995
C479979	GW0742	[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT10 mRNA	19748995
C479979	GW0742	PPARD protein mutant form inhibits the reaction [[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT10 mRNA]	19748995
D006820	Hyaluronic Acid	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of KRT10 protein]	23178681
D006820	Hyaluronic Acid	Hyaluronic Acid analog results in increased expression of KRT10 protein	23178681
C029424	hydrazine	hydrazine results in decreased expression of KRT10 mRNA	15282401
D006861	Hydrogen Peroxide	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of KRT10 protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of KRT10 protein	23178681
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of KRT10 mRNA	20871596
D007854	Lead	KRT10 protein binds to Lead	23896426
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of KRT10 mRNA	23649840
D015741	Metribolone	Metribolone results in decreased expression of KRT10 protein	17152098
C063855	microcystin RR	microcystin RR results in decreased expression of KRT10 protein	19111056
C063855	microcystin RR	microcystin RR results in increased expression of KRT10 protein	19111056
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of KRT10 mRNA	26924002
D009020	Morphine	Morphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein]	23056601
D009020	Morphine	Morphine results in decreased expression of KRT10 protein	23056601
D009151	Mustard Gas	Mustard Gas results in increased expression of KRT10 protein	11428642\|9665388
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of KRT10 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of KRT10 mRNA"	25554681
C031721	naphthalene	naphthalene results in increased reduction of KRT10 protein	19843705
D009532	Nickel	KRT10 protein binds to Nickel	23896426
D009532	Nickel	Nickel affects the expression of KRT10 mRNA	14575637
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of KRT10 mRNA]	14575637
C012655	nimesulide	[[GW0742 binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA	19748995
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]"	23566955
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT10 mRNA]"	23566955
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT10 mRNA"	18633435
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT10 protein"	18633435
C002741	N-nitrosomorpholine	N-nitrosomorpholine affects the expression of KRT10 protein	19716841
D009966	Orphenadrine	Orphenadrine affects the expression of KRT10 mRNA	23665939
D000073878	Palm Oil	Palm Oil results in increased expression of KRT10 mRNA	18042831
D052638	Particulate Matter	Particulate Matter results in decreased expression of KRT10 mRNA	28341207
D052638	Particulate Matter	Particulate Matter results in decreased expression of KRT10 protein	28341207
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of KRT10 protein	19954255
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of KRT10 protein	19854247
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of KRT10 protein	26879310
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of KRT10 mRNA	17616710
D028321	Plant Preparations	Plant Preparations results in increased expression of KRT10 protein	28284660
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of KRT10 protein	19771553
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of KRT10 protein	19771553
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of KRT10 mRNA	19162173
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of KRT10 mRNA	18077114
D015474	Isotretinoin	Isotretinoin results in decreased expression of KRT10 mRNA	15982314
C541923	sandostatinLAR	sandostatinLAR results in increased expression of KRT10 mRNA	17210224
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of KRT10 protein	25895662
C009277	sodium arsenate	sodium arsenate results in decreased expression of KRT10 mRNA	12727804
C017947	sodium arsenite	sodium arsenite inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]	23566955
C017947	sodium arsenite	sodium arsenite results in decreased expression of KRT10 mRNA	23566955\|2871322
C017947	sodium arsenite	sodium arsenite results in decreased expression of KRT10 protein	28713220
C017947	sodium arsenite	sodium arsenite results in increased expression of KRT10 mRNA	12727804\|1952463
C017947	sodium arsenite	sodium arsenite results in increased expression of KRT10 protein	18572023\|1952463
C028982	sodium chromate(VI)	sodium chromate(VI) results in increased expression of KRT10 protein	19771553
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in decreased expression of KRT10 protein modified form	24464499
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of KRT10 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of KRT10 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of KRT10 mRNA	16985168\|9525283
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KRT10 protein	21410761
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of KRT10 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of KRT10 mRNA	21215274
C009495	titanium dioxide	titanium dioxide results in decreased expression of KRT10 mRNA	23409001
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of KRT10 mRNA	27404394\|2748027
D014212	Tretinoin	Tretinoin metabolite results in increased expression of KRT10 mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of KRT10 mRNA	15982314\|1698516
D014212	Tretinoin	Tretinoin results in increased expression of KRT10 mRNA	9716179
D014212	Tretinoin	Tretinoin results in increased expression of KRT10 protein	9716179
D014212	Tretinoin	Tretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT10 mRNA]	10748128
D014212	Tretinoin	Tretinoin results in decreased expression of KRT10 mRNA	10748128
D014212	Tretinoin	Tretinoin results in increased expression of KRT10 protein	10697544
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of KRT10 mRNA]	14575637
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]	18633435
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of KRT10 protein]	18633435
C113580	U 0126	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT10 mRNA]"	23566955
C113580	U 0126	U 0126 results in increased expression of KRT10 mRNA	23566955
D014635	Valproic Acid	Valproic Acid affects the expression of KRT10 mRNA	25979313
D014638	Vanadates	Vanadates results in decreased expression of KRT10 mRNA	9219563
D024483	Vitamin K 3	Vitamin K 3 affects the expression of KRT10 mRNA	20044591
C009680	VX	VX binds to KRT10 protein	22521715
D015032	Zinc	KRT10 protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0030280	structural constituent of epidermis	-	IDA	7543090
GO:0030280	structural constituent of epidermis	-	NAS	2459124
GO:0046982	protein heterodimerization activity	-	IDA	27595935

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0018149	peptide cross-linking	-	IDA	7543090
GO:0030216	keratinocyte differentiation	-	IEP	22170488
GO:0031424	keratinization	-	TAS	-
GO:0045684	positive regulation of epidermis development	-	ISS	-
GO:0051290	protein heterotetramerization	-	IDA	27595935
GO:0070268	cornification	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001533	cornified envelope	-	IDA	7543090
GO:0005615	extracellular space	-	HDA	23580065
GO:0005634	nucleus	-	HDA	21630459
GO:0005737	cytoplasm	-	IDA	22170488
GO:0005829	cytosol	-	TAS	-
GO:0005882	intermediate filament	-	NAS	2459124
GO:0016020	membrane	-	HDA	19946888
GO:0070062	extracellular exosome	-	HDA	11487543 19199708 23533145

KEGG ID	KEGG Term
hsa05150	Staphylococcus aureus infection

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-6805567	Keratinization	TAS
R-HSA-6809371	Formation of the cornified envelope	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28944608	Coexistence of mutations in keratin 10 (KRT10) and the mitochondrial genome in a patient with ichthyosis with confetti and Leber's hereditary optic neuropathy. (2017 Nov)	Kalinska-Bienias A	Am J Med Genet A