Gene: KRT10

3858
BCIE|BIE|CK10|EHK|K10|KPP
keratin 10
protein-coding
17q21.2
Ensembl:ENSG00000186395 MIM:148080 Vega:OTTHUMG00000133368 UniprotKB:P13645
NG_008405.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.530e-1 (AD)  8.021e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPL35A0.724
RPL240.715
TMA70.712
RPL140.711
MSRB20.709
POLR2J0.707
RPL170.704
RPS70.702
RPL310.701
GTF3C60.697

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.598
OR4F29-0.57
OR2M4-0.239
IL1RAPL2-0.202
NPBWR2-0.186
WDR87-0.186
LINC00348-0.184
PCDHA7-0.18
PROKR2-0.171
PCDHA6-0.17

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KRT10 mRNA"19114083
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of KRT10 protein22434383
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of KRT10 protein"23457121
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of KRT10 protein24140754
C0331704-bromo-A-231874-bromo-A-23187 results in increased expression of KRT10 mRNA16621454
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of KRT10 mRNA15982314
D000082AcetaminophenAcetaminophen affects the expression of KRT10 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KRT10 mRNA27153756
C103303alitretinoinalitretinoin results in decreased expression of KRT10 mRNA15982314
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of KRT10 mRNA28713220
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of KRT10 protein28713220
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of KRT10 mRNA24449571
D001149ArsenatesArsenates results in decreased expression of KRT10 mRNA9219563
C015001arsenitearsenite results in decreased expression of KRT10 mRNA18633435
C015001arsenitearsenite results in decreased expression of KRT10 protein18633435
C015001arseniteJAG1 protein inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]18633435
C015001arsenitetyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]18633435
C015001arsenitetyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of KRT10 protein]18633435
C547126AZM551248AZM551248 results in decreased expression of KRT10 mRNA22323515
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of KRT10 mRNA16985168
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in decreased expression of KRT10 protein modified form24464499
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of KRT10 mRNA"19150397
C075388beta-damascenonebeta-damascenone results in increased expression of KRT10 mRNA22982537
D004958EstradiolEstradiol results in decreased expression of KRT10 mRNA23019147|2870126
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT10 mRNA]28701262
D004958EstradiolEstradiol results in decreased expression of KRT10 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of KRT10 mRNA28701262
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A affects the expression of KRT10 mRNA]28701262
C006780bisphenol Abisphenol A results in increased expression of KRT10 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of KRT10 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of KRT10 protein22174045
C515564bromovaninbromovanin results in decreased expression of KRT10 protein21419150
D002104CadmiumKRT10 protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KRT10 mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KRT10 protein21699967
C055085calcipotrienecalcipotriene results in decreased expression of KRT10 protein7508215
D000074262Canola OilCanola Oil metabolite results in decreased expression of KRT10 mRNA27363782
C007020chlorophyllinchlorophyllin analog results in increased expression of KRT10 protein22852132
C100187chloropicrinchloropicrin results in increased expression of KRT10 mRNA26352163
D002840ChromatesChromates results in decreased expression of KRT10 mRNA9219563
C041167chromium nitratechromium nitrate results in increased expression of KRT10 protein19771553
D003300CopperKRT10 protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of KRT10 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of KRT10 mRNA21163907|2556210
D016572CyclosporineCyclosporine results in increased expression of KRT10 mRNA23308384|2504735
D016572CyclosporineCyclosporine results in increased expression of KRT10 protein23308384|2504735
C042577diallyl trisulfidediallyl trisulfide results in increased expression of KRT10 protein19550292
D015946Ethylene DibromideEthylene Dibromide results in decreased expression of KRT10 protein22434383
D002945CisplatinCisplatin results in decreased expression of KRT10 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of KRT10 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of KRT10 mRNA18042831
D004052Diethylnitrosamine"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of KRT10 protein"23457121
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of KRT10 mRNA15171707
D002117CalcitriolCalcitriol results in decreased expression of KRT10 protein7508215
D002117CalcitriolCalcitriol results in increased expression of KRT10 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of KRT10 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of KRT10 mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of KRT10 mRNA26924002
D004317DoxorubicinDoxorubicin affects the expression of KRT10 protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KRT10 protein23301498
D000431EthanolEthanol results in increased expression of KRT10 protein23200777
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KRT10 mRNA15576828
D015025ZearalenoneZearalenone results in decreased expression of KRT10 protein25058043
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A affects the expression of KRT10 mRNA]28701262
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT10 mRNA]28701262
C479979GW0742[[GW0742 binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA19748995
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT10 mRNA19748995
C479979GW0742PPARD protein mutant form inhibits the reaction [[GW0742 binds to and results in increased activity of PPARD protein] which results in increased expression of KRT10 mRNA]19748995
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of KRT10 protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in increased expression of KRT10 protein23178681
C029424hydrazinehydrazine results in decreased expression of KRT10 mRNA15282401
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of KRT10 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of KRT10 protein23178681
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KRT10 mRNA20871596
D007854LeadKRT10 protein binds to Lead23896426
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KRT10 mRNA23649840
D015741MetriboloneMetribolone results in decreased expression of KRT10 protein17152098
C063855microcystin RRmicrocystin RR results in decreased expression of KRT10 protein19111056
C063855microcystin RRmicrocystin RR results in increased expression of KRT10 protein19111056
C517284monomethyl phthalatemonomethyl phthalate affects the expression of KRT10 mRNA26924002
D009020MorphineMorphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein]23056601
D009020MorphineMorphine results in decreased expression of KRT10 protein23056601
D009151Mustard GasMustard Gas results in increased expression of KRT10 protein11428642|9665388
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KRT10 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KRT10 mRNA"25554681
C031721naphthalenenaphthalene results in increased reduction of KRT10 protein19843705
D009532NickelKRT10 protein binds to Nickel23896426
D009532NickelNickel affects the expression of KRT10 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of KRT10 mRNA]14575637
C012655nimesulide[[GW0742 binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA19748995
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]"23566955
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT10 mRNA]"23566955
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT10 mRNA"18633435
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT10 protein"18633435
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of KRT10 protein19716841
D009966OrphenadrineOrphenadrine affects the expression of KRT10 mRNA23665939
D000073878Palm OilPalm Oil results in increased expression of KRT10 mRNA18042831
D052638Particulate MatterParticulate Matter results in decreased expression of KRT10 mRNA28341207
D052638Particulate MatterParticulate Matter results in decreased expression of KRT10 protein28341207
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of KRT10 protein19954255
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of KRT10 protein19854247
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of KRT10 protein26879310
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of KRT10 mRNA17616710
D028321Plant PreparationsPlant Preparations results in increased expression of KRT10 protein28284660
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of KRT10 protein19771553
D011192Potassium DichromatePotassium Dichromate results in increased expression of KRT10 protein19771553
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of KRT10 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of KRT10 mRNA18077114
D015474IsotretinoinIsotretinoin results in decreased expression of KRT10 mRNA15982314
C541923sandostatinLARsandostatinLAR results in increased expression of KRT10 mRNA17210224
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of KRT10 protein25895662
C009277sodium arsenatesodium arsenate results in decreased expression of KRT10 mRNA12727804
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]23566955
C017947sodium arsenitesodium arsenite results in decreased expression of KRT10 mRNA23566955|2871322
C017947sodium arsenitesodium arsenite results in decreased expression of KRT10 protein28713220
C017947sodium arsenitesodium arsenite results in increased expression of KRT10 mRNA12727804|1952463
C017947sodium arsenitesodium arsenite results in increased expression of KRT10 protein18572023|1952463
C028982sodium chromate(VI)sodium chromate(VI) results in increased expression of KRT10 protein19771553
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in decreased expression of KRT10 protein modified form24464499
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of KRT10 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of KRT10 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KRT10 mRNA16985168|9525283
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KRT10 protein21410761
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KRT10 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KRT10 mRNA21215274
C009495titanium dioxidetitanium dioxide results in decreased expression of KRT10 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KRT10 mRNA27404394|2748027
D014212TretinoinTretinoin metabolite results in increased expression of KRT10 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of KRT10 mRNA15982314|1698516
D014212TretinoinTretinoin results in increased expression of KRT10 mRNA9716179
D014212TretinoinTretinoin results in increased expression of KRT10 protein9716179
D014212TretinoinTretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT10 mRNA]10748128
D014212TretinoinTretinoin results in decreased expression of KRT10 mRNA10748128
D014212TretinoinTretinoin results in increased expression of KRT10 protein10697544
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of KRT10 mRNA]14575637
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]18633435
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of KRT10 protein]18633435
C113580U 0126"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT10 mRNA]"23566955
C113580U 0126U 0126 results in increased expression of KRT10 mRNA23566955
D014635Valproic AcidValproic Acid affects the expression of KRT10 mRNA25979313
D014638VanadatesVanadates results in decreased expression of KRT10 mRNA9219563
D024483Vitamin K 3Vitamin K 3 affects the expression of KRT10 mRNA20044591
C009680VXVX binds to KRT10 protein22521715
D015032ZincKRT10 protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030280structural constituent of epidermis-IDA7543090  
GO:0030280structural constituent of epidermis-NAS2459124  
GO:0046982protein heterodimerization activity-IDA27595935  
GO ID GO Term Qualifier Evidence PubMed
GO:0018149peptide cross-linking-IDA7543090  
GO:0030216keratinocyte differentiation-IEP22170488  
GO:0031424keratinization-TAS-  
GO:0045684positive regulation of epidermis development-ISS-  
GO:0051290protein heterotetramerization-IDA27595935  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IDA7543090  
GO:0005615extracellular space-HDA23580065  
GO:0005634nucleus-HDA21630459  
GO:0005737cytoplasm-IDA22170488  
GO:0005829cytosol-TAS-  
GO:0005882intermediate filament-NAS2459124  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA11487543  19199708  23533145  
KEGG ID KEGG Term
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28944608Coexistence of mutations in keratin 10 (KRT10) and the mitochondrial genome in a patient with ichthyosis with confetti and Leber's hereditary optic neuropathy. (2017 Nov)Kalinska-Bienias AAm J Med Genet A